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The Binding of Transition Metal Ions to DNA Oligonucleotides Studied by Nuclear Magnetic Resonance Spectroscopy

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Part of the book series: NATO ASI Series ((ASEN2,volume 26))

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Abstract

Trace amounts of metals determine not only the course of malignancy, but they can be the cause of malignant transformation [1]. The molecular mechanism of metal ion carcinogenesis is still not well understood. Several theories have been proposed to explain the carcinogenic activities of the respective metals. However, at present, no unifying concept has been developed to explain why metals or metal-containing compounds induce cancer in animals. Especially puzzling is the fact that closely related metal species have widely different carcinogenic properties. In a comparison of metal carcinogenicity in humans based on several experimental factors Cr and Ni turned out to be the most potent carcinogens [2]

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Authors and Affiliations

  1. Department of Chemistry, University of Bergen, Allegt. 41, N-5007, Bergen, Norway

    Einar Sletten

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  1. Einar Sletten
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Editors and Affiliations

  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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© 1997 Springer Science+Business Media Dordrecht

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Sletten, E. (1997). The Binding of Transition Metal Ions to DNA Oligonucleotides Studied by Nuclear Magnetic Resonance Spectroscopy. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_31

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  • DOI: https://doi.org/10.1007/978-94-011-5780-3_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6440-8

  • Online ISBN: 978-94-011-5780-3

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