Abstract
Cells have the general capacity to develop resistance to toxic elements which include compounds present in polluted environment as well as antibiotics used in chemotherapy for the treatment of cancer or in diseases related to the presence of parasitic protozoa, bacteria, fungi etc.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Silver, S. and Walderhaug, M. (1992) Regulation of chromosomal and plasmid cation and anion transport systems. Microbiol. Rev., 56, 1–33
Dano, K. (1973) Active outward transport of daunomycin in resistant Ehrlich ascites tumors cells. Biochim.Biophys. Acta. 323, 466–483
Higgins, CF. (1992) ABC transporters — From microorganisms to man. Anuu. Rev. Cell. Biol. 8, 67–113
Schinkel, A.H., Roelofs, M.E.M., and Borst, P. (1991) Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antobodies. Cancer Res. 51, 2628–2635
Gottesman, M.M., and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385–427
Bradley, G., Juliano, R.L, and Ling, V. (1988) Mechanism of multidrug resistance. Biochim. Biophys. Acta. 948, 87–128
Cole, S.P.C., Sparks, K.E., Fraser, K., Loe, D.W., Grant, C.E., Wilson, G.M. and Deeley, R.G. (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54, 5902–5910
Zaman, G.J.R. Lankelma, J., van Tellingen, O., Beijnen, J., Dekker, H., Paulusma, C., Oude Elferink, R.P.J., Baas, F. and Borst, P. (1995) Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc. Natl. Acad. Sci. USA 92, 7690–7694
Higgins, C.F., Hiles, I.D. Salmond, G.P.C, Gill, D.R., Downie, J.A. et al. (1986) A family of related ATP binding subunits coupled to many distinct biological processes in bacteria Nature 323, 448–450
Hyde, S.C, Emsley, P., Hartshorn, M, Mimmack, M.M., Gileadi, U., et al (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346, 362–365
Mimura, C.S. Admon, A., Kurt, K.A., and Ames, G.F.L. (1990) The nucleotide-binding site of HisP, a membrane protein of the histidine permease. Identification of amino acid residues photoaffinity labelled by 8-azido ATP. J. Biol. Chem. 265, 19535–19542
Chen, C-J. Chin, J.E., Ueda, K., Clark, D. P., Pastan, L. et al. (1986). Internal duplication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47, 381–389
Gros, P., Croop, J., and Housman, D. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicating strong homology to bacterial transport proteins. Cell. 47, 371–80
Higgins, C.F., Hiles, L.D., Whalley, K., and Jamieson, D.J. (1985) Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems. EMBO J. 4, 1033–1040
Azzaria, M., Schurr, E. and Gros, P. (1989) Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr 1 gene abolish its ability to confer multidrug resistance. Mol. Cell. Biol. 9, 5289–5297
Berkower, C, and Michaelis, S. (1991) Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. EMBO J. 10, 3777–785
Mimmack, M.L., Gallagher, M.P., Hyde, S.C., Pearce, S.R., Booth, L.R., and Higgins, C.F. (1989) Energy-coupling to periplasmic binding protein-dependent transport systems: Stoichiometry of ATP hydrolysis during transport. Proc. Natl. Acad. Sci USA 86, 8257–261
Horio, M., Gottesman, MM. and Pastan, I. (1988) ATP-dependent transport of vinblastine in vesicles from human multidrug resistant cells. Proc. Natl. Acad. Sci. USA 85, 3580–584
Ames, G. F.L., Nikaido, K, Groarke, J, and Petithory, J. (1989) Reconstitution of periplasmic transport in inside-out membrane vesicles: energization by ATP. J. Biol. Chem. 264, 3998–4002
Buschman, F., and Gros,, P. (1991) Functional analysis of chimeric genes obtained by exchanging homologous domains of mouse mdr 1 and mdr 2 genes. Mol. Cell. Biol. 11, 595–603
Lee, T.C., Oshimara, M., and Barrett, J.C. (1985) Comparison of arsenic induced cell transformation, cytotoxoticity, mutation and cytogenetic effects in syrian hamster embryo cells in culture. Carcinogenesis 6, 1421–1426
Nakamuro, K., and Sayato, Y. (1981) Comparative studies of chromosomal aberrations induced by trivaient and pentavalent arsenic. Mutaat. Res. 88, 73–80
Pershagen, G. (1985) Lung cancer mortality among men living near arsenic-emitting smelters. Am. J. Epidemiol. 122, 684–694
Schneidman, D. and Belizaire, R. (1986) Arsenic exposure followed by the development of dermatofibrosarcoma protuberans. Cancer 58, 1585–1587
Bates, M.N., Smith, A.H., and Hopenhayn-Rich, C. (1992) Arsenic ingestion and internal cancers: a review. Am. J. Epidemiol. 135, 462–476
Nielsen, F.H. (1991) Nutritional requirements for boron, silicon, vanadium, nickel and arsenic: current knowledge and speculation. FASEB J. 5, 2661–266
World Health Organization (1981) Environmental Health Criteria Arsenic. Vol 16. United Nations Environment Programm International Labor Organization and World Health Organization Geneva.
Edelmau, P. (1990) Environmental and work place contamination in the semiconductor industry implications for future health of the work force and community. Environ. Health Perspect. 86, 291–295
Nakamuro, K. and Sayato, Y. (1981) Comparative studies of chromosomal aberrations induced by trivaient and pentavalent arsenic. Mutat. Res. 88, 73–80
Klemperer, N.S., and Pickart, C.M. (1989) Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway. J. Biol. Chem1. 264, 19245–19252
Kenney, L.J., and Kaplan, J.H. (1988) Arsenate substitutes for phosphate in the human red cell sodium pump and anion exchanger. J. Biol. Chem. 263, 7954–7960
Silver, S., and Misra, T.K. (1988) Plasmid-mediated heavy metal resistance. Annu.Res. Microbiol. 42, 717–743
Silver, S. Nucifora, G., Chu, L., and Misra, T.K. (1989) Bacterial resistance ATPases: Primary pumps for exporting toxic cations and anions. Trends Biochem. Sci 14, 76–80
Anderson, G.L., Williams, J., and Hille, R. (1992) The purification and characterization of arsenite oxidase from Alcaligenes faecalis. a molybdenum-containing hydroxylase. J. Biol. Chem. 267, 23674–23682
Rauser, W.E. (1990) Phytochelatins. Annu. Rev. Biochem. 59, 61–86
Hamer, D., Thiele, DJ., and Lemontt, J.E. (1985) Function and autoregulation of yeast copperthionein. Science 228, 685–690
Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L., and Palmiter, R.D.(1994) Targeted disruption of metallothionein I and II genes increses sensitivity to cadmium. Proc. Natl. Acad. Sci. USA 91, 584–588
Dey, S. Ouellette, M., Lightbody, J., Papadopoulou, B., and Rosen, B.P. (1996) An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. Proc. Natl. Acad. Sci. USA 93, 2192–2197
Ishikawa, T. (1989) ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicle. Biol. Chem. 264, 17343–17348
Ji, G., and Silver, S. (1992) Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258. Proc. Natl. Acad. Sci. USA 89, 9474–9478
Gladysheva, T.B., Oden, K.L., and Rosen, B.P. (1994) Properties of the arsenate reductase of plasmid R773. Biochemistry 33, 7287–7293
Cole, S.P.C., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., Stewart, A.J., Kurz, E.U., Duncan, A.M.V., and Deeley, R.G. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cell line. Science 258, 1650–1654
Scheper, R.J., Broxterman, H.J., Scheffer, G.L., Kaaijk, P. Dalton, W.S., van Heijningen, H.M., van Kalken, C.K., Slovak, M.L., de Vries, E.G.E., van der Valk, P., Meijer, C.J.L.M., and Pinedo, H.M. (1993) Overexpression of a M r 110, 000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res. 53, 1475–1479
Safa, A.R. (1992) Photoaffinity labeling of P-glycoprotein in multidrug-resistant cells. Cancer Invest. 10, 295–305
Spoelstra, E.C., Westerhoff, H.V., Dekker, H., and Lankelnia, J. (1992) Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur. J. Biochem. 207, 567–579
Mankhetkorn, S., Dubru, F., Hesschenbrouck, J., Fiallo, M., and Garnier-Suillerot, A. (1996) Relation among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediated efflux of daunorubicin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug-resistant K562 cells. Mol. Pharmacol. 49, 532–539
Urbatsch, I.L., Sankara, B., Bhagat, S., and Senior, A.E. (1995) Both P-glycoprotein nucleotide-binding sites are catalytically active. J. Biol. Chem. 270, 26956–26961
Al-Shawi, M.K., Urbatsch, I.L., and Senior, A.E. (1994) Covalent inhibitors of P-glycoprotein ATPase activity. J. Biol. Chem 269, 8986–8992
Loo, T.W., and Clarke, D.M. (1994) Reconstitution of drug-stimulated ATP-ase activity following co-expression of each half of human P-glycoprotein as separate polypeptides. J. Biol. Chem. 269, 7750–7755
Eytan, G.D., Regev, R., and Assaraf, Y.G. (1996) Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis. 271, 3172–3178
Jedlitschky, G., Leier, I., Bucholz, U., Center, M., and Keppler, D. (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res. 54, 4833–36
Leier, I., Jedlitschky, G., Buchholz, U., and Keppler, D., (1994) Characterization of the ATP-dependent leukotriene C4, export carrier in mastocytoma cells. Eur. J. Biochem. 220, 599–606
Müller, M., Meijer, C., Zaman, G.J.R., Borst, P., Scheper, R.J. et al. (1994) Overexpression of the multidrug resistance associated protein (MRP) gene results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. 91, 13033–13037
Oude Elferink, R.P.J., Ottenhof, R. Liefting, W., De Haan, J., and Jansen, P.L.M., (1989) Hepatobiliary transport of glutathioue and glutathione conjugate in rats with hereditary hyperbilirubinemia. J. Clin. Invest 84, 476–483
Heijn, M., Oude Elferink, R.P.J., and Jansen, P.L.M. (1992) ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles. Am. J. Physiol. 262, C104–10
Ishikawa, T. (1992) The ATP-dependent gultathione S-conjugate export pump. Trends Biol. Sci. 17, 463–68
Zaman, G.J., Flens, M.J., van Leusden, M.R., de Haas, M., Mulder, H.S., Lankelma, J. et al. (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl. Acad. Sci. USA 91, 8822–8826
Leier, J., Jedlitschky, G., Buchholz, U., Cole, S.P., Deeley, R.G., and Keppler, D. (1994) The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem. 269, 27807–27810
Feller, N., Broxterman, H.J., Wahrer, D.C., and Pinedo, H.M. (1995) ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett. 368, 385–388.
Versantvooft, C.H., Broxterman, H.J., Bagrij, T., Scheper, R.J., and Twentyman P.R. (1995) Regulation by glutathione of drug transport in tnultidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br. J. Cancer. 72, 82–89
Timmer-Bosscha, H. Timmer, A., Meijer, C., de Vries, E.G.E., de Jong. B. Oosterhuis, J.W., and Mulder, N.H. (1993) cis-dianiminedichloroplatinum (II) resistance in vitro and in vivo in human embryonal carcinoma cells. Cancer Res. 53, 5707–5713
Andrews, P.A., and Howell, S.B. (1990) Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance. Cancer Cells (Cold Spring Harbor). 2, 35–43
Scanlon, K.J. Kashani-Sabet, M., Miyachi, H., Sowres, L.C., and Rossi, J. (1989) Molecular basis of cisplatin resistance in human carcinomas: model systems and patients. Anticancer Res. 9. 1301–1312
Ishikawa, T., Wright, C.D., and Ishizuka, H. (1994) GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J. Biol. Chem. 269, 29085–29093
Ishikawa, T., and Ali-Osman. F. (1993) Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J. Biol. Chem. 268, 20116–21125
Delmon-moingeon, L., Piwnica-Worms, D., Van den Abbele, A.D., Holman, B.L., Davison, A., and Jones, A.G.(1990) Uptake of the cation hexakis (2-inethoxyisobutylisonitrile)-technetium-99m by human carcinoma cells lines in vitro. Cancer Res. 50, 2198–2202
Maublant, J.G., Zhang, Z., Rapp, M., Michelot, J., and Veyre, A. (1993) In vitro uptake of technetium 99m-teboroxime in carcinoma cell lines and normal cells: comparison with technetium-99m-sestamibi and thallium-201. J. Nucl. Med. 34, 1949–1952
Piwnica-Worms. D. Chiu, M.L., Budding, M., Kronauge, J.F., Kramer, R.A., and Groop, J.M. (1993) Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res. 53, 977–983
Piwnica-Worms, D., Rao, V.V., Kronauge, J.F., and Croop, J.M. (1995) Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry 34, 12210–12220
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Garnier-Suillerot, A. (1997). Active Efflux Mechanisms for Cellular Resistance. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_19
Download citation
DOI: https://doi.org/10.1007/978-94-011-5780-3_19
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6440-8
Online ISBN: 978-94-011-5780-3
eBook Packages: Springer Book Archive