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Aluminium(III) Speciation and Biological Effects

Implications In Human and Experimental Toxicity

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Part of the book series: NATO ASI Series ((ASEN2,volume 26))

Abstract

Aluminium [Al(III)] is the third most abundant element as well as the most abundant metal-ion on the Earth’s crust. Apparently, Al(III) has no useful biological functions. However, few papers, as well as preliminary data from our laboratory, seem to indicate a possible role of Al(III) in the growing of animals and cell cultures [1]. The first toxicological studies on Al(III) were reported by Siems and Doellken respectively in 1886 and 1887 [2, 3]. A revival of interest on aluminium biology raised when Alfrey and coll. [4, 5] proved a connection between aluminium and certain pathologies, such as microcytic anemia, osteomalacia and dementia dialitica, related to the dialysis treatment of uremic patients. Furthermore, a possible connection between aluminium, as an aethiological factor and Alzheimer’s disease (AD) was first hypothesised by McLachlan and coll., in the early ’70s [6] but the issue is far to be fully demonstrated and it is still matter of discussion and investigation [7].

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Author information

Authors and Affiliations

  1. CNR-Center on Metalloproteins at the Department of Biology, University of Padova, Via Trieste 75, 35131, Padova, Italy

    P. Zatta & P. Zambenedetti

Authors
  1. P. Zatta
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  2. P. Zambenedetti
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Editor information

Editors and Affiliations

  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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© 1997 Springer Science+Business Media Dordrecht

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Zatta, P., Zambenedetti, P. (1997). Aluminium(III) Speciation and Biological Effects. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_12

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  • DOI: https://doi.org/10.1007/978-94-011-5780-3_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6440-8

  • Online ISBN: 978-94-011-5780-3

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