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Detection of antiperinuclear factor and antikeratin antibodies

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Manual of Biological Markers of Disease

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Abstract

The diagnosis of rheumatoid arthritis (RA) is initially based on clinical manifestations. Serological support for such a diagnosis is not very well established and depends mainly on the presence of rheumatoid factors (RF). A positive RF test has a predictive value [1] and is related to disease with a more severe outcome [2]. However, RF is also present in other (autoimmune) diseases and in control sera from healthy people [3]. Therefore, testing for a second RA-specific antibody is very useful, especially for the management of seronegative RA patients. Both the antiperinuclear factor (APF) (reviewed in [4]) and antikeratin antibodies (AKA) (reviewed in [4] and [5]) are helpful in this respect.

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Abbreviations

APF:

antiperinuclear factor

AKA:

antikeratin antibody

RA:

rheumatoid arthritis

RF:

rheumatoid factor

WHO:

World Health Organization

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Nijmegen, P.O. Box 9101, NL, 6500 HB, Nijmegen, The Netherlands

    R. M. A. Hoet

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  1. R. M. A. Hoet
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Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1993 Springer Science+Business Media Dordrecht

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Hoet, R.M.A. (1993). Detection of antiperinuclear factor and antikeratin antibodies. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_10

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  • DOI: https://doi.org/10.1007/978-94-011-5444-4_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4243-4

  • Online ISBN: 978-94-011-5444-4

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