Abstract
The genome projects are changing biology by the genetic blueprints of entire organisms. The blueprints are tantalizing but we cannot deduce everything we need to know from them, including the structures and detailed functions of proteins. In this paper we describe an approach for obtaining structural information about proteins on a genomic scale. We describe how structural and functional information might eventually be put together to form a basis for describing life at many levels. We then describe how structural information fits into this picture and classes of proteins for which structural information would be useful in a genomic context. We conclude with a proposal for an initiative to determine protein structures on a very large scale
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Braig, K., Otwinowski, Z., Hegde, R., Bosvert, C. C., Joachimiak, A., Horwich, A. L., Sigler, P. B. 1994. Nature 371: 578–586.
Chothia C, Lesk AM. 1986. The relation between the divergence of sequence and structure in proteins EMBO J 5:823–826.
Orengo CA, Jones DT Thornton, JM. 1994. Protein superfamilies and domain superfolds. Nature 372: 631–634.
Pennisi, 1998 Taking a Structured Approach to Understanding Proteins. Science 279: 978–979.
Terwilliger, T. C., Waldo, G., Peat, T. S., Newman, J. M., Chu, K., & Berendzen, J. (1998). Class-directed structure determination: Foundation for a Protein Structure Initiative. Protein Science, in press
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Terwilliger, T.C., Berendzen, J. (1999). Exploring Structure Space. In: Bradbury, E.M., Pongor, S. (eds) Structural Biology and Functional Genomics. NATO Science Series, vol 71. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4631-9_15
Download citation
DOI: https://doi.org/10.1007/978-94-011-4631-9_15
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-5782-7
Online ISBN: 978-94-011-4631-9
eBook Packages: Springer Book Archive