Skip to main content

Genetic polymorphisms in drug metabolism: clinical implications and consequences in ADME studies

  • Chapter
The Relevance of Ethnic Factors in the Clinical Evaluation of Medicines

Part of the book series: CMR Workshop Series ((CMRW))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Alván G, Balant LP, Bechtel, PR, Boobis AR, Gram LF and Pithan K (eds) (1990). Proceedings European Consensus Conference on Pharmacogenetics. Commission of the European Communities (Co-ordinated Action COST B1), Luxembourg.

    Google Scholar 

  • Andersson T, Regardh CG, Lou YC, Zhang Y, Dahl ML and Bertílsson L(1992). Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects. Pharmacogenetics 2: 25–31.

    Article  PubMed  CAS  Google Scholar 

  • Balant LP, Gundert-Remy U, Boobis AR and von Bahr Ch (1989). Relevance of genetic polymorphism in drug metabolism in the development of new drugs. Eur J Clin Pharmacol 36: 551–554.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson L, Aberg-Wistedt A, Gustafsson LL, Nordin C (1985). Extremely rapid hydroxylation of debrisoquine: a case report with implications for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit 7:478–480.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson L, Henthorn TK, Sanz E, Tybring G, Säwe J and Villén T (1989). Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquine, hydroxylation phenotype. Clin Pharmacol Ther 45: 348–355.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson L, Dahl M-L, Sjögvist F, Asberg-WistedtA, Humble M, Johansson I, Lundquist E and Ingelman-Sundberg M (1993). Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet 341: 63.

    Article  PubMed  CAS  Google Scholar 

  • Breimer, DD (1983). Interindividual variations in drug disposition. Clinical implications and methods of investigation. Clin Pharmacokin 8: 371–377.

    Article  CAS  Google Scholar 

  • Breimer DD (1990). Potential clinical relevance of the interplay between genetic and environmental factors. In: Alván et al. (eds) pp. 69–80.

    Google Scholar 

  • Breimer DD and Schellens JHM (1990). A “cocktail” strategy to assess in vivo oxidative drug metabolism in humans. Trends Pharmacol Sci 11: 223–225.

    Article  PubMed  CAS  Google Scholar 

  • Cholerton S, Daly AK and Idle JR (1992). The role of individual human cytochromes P-450 in drug metabolism and clinical response. Trends Pharmacol Sci 13: 434–439.

    Article  PubMed  CAS  Google Scholar 

  • Dayer P (1990). Advantages and drawbacks of probe drugs for the assessment of the phenotypic expression of cytochrome P-450 DB 1 (P450IID6). In: Alván et al. (eds), pp. 33–42.

    Google Scholar 

  • Eichelbaum M and Gross AS (1992). The genetic polymorphism of debrisoquine/sparteine metabolism - clinical aspects. In: Kalow W (ed.), pp. 625–648

    Google Scholar 

  • Eichelbaum M, Spannbrucker N, Steincke B and Dengler HJ (1979). Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 16:153.

    Google Scholar 

  • Gonzalez FJ (1992). Human cytochromes P450: problems and prospects. Trends Pharmacol Sci 13:346–352.

    Article  PubMed  CAS  Google Scholar 

  • Kalow W (ed.) (1992). Pharmacogenetics of Drug Metabolism. Pergamon Press, New York.

    Google Scholar 

  • Koymans LMH, Vermeulen NPE, van Acker SABE, te Koppele JM, Heykants JJP, Lavrijsen K, Meuldermans W and Donné-Op den Kelder GM (1992). A predictive model for substrates of cytochrome P-450 debrisoquine (2D6). Chem Res Toxicol 5:211–219.

    Article  PubMed  CAS  Google Scholar 

  • Küpfer A and Preisig P (1984). Pharmacogenetics of mephenytoin: a new hydroxylation polymorphism in man. Eur J Clin Pharmacol 26:753–759.

    Article  PubMed  Google Scholar 

  • La Du BN (1992). Overview of pharmacogenetics. In: Kalow W (ed.), pp. 1–12.

    Google Scholar 

  • Lennard MS (1992). The polymorphic oxidation of beta-adrenoreceptor antagonists. In: Kalow W (ed.), pp. 701–720.

    Google Scholar 

  • Mahgoub A, Idle JR, Dring LG, Lancester R and Smith RL (1977). Polymorphic hydroxylation of debrisoquine in man. Lancet 2:584–586.

    Article  PubMed  CAS  Google Scholar 

  • Meyer UA, Skoda RC, Zanger UM, Heim M and Broly F (1992). The genetic polymorphism of debrisoquine/ sparteine metabolism - molecular mechanisms. In: Kalow W (ed.), pp. 609–623.

    Google Scholar 

  • Price Evans DA (1992). N-Acetyltransferase. In: Kalow W (ed.), pp. 95–178.

    Google Scholar 

  • Sjögvist F (1992). Pharmacogenetic factors in the metabolism of tricyclic antidepressants and some neuroleptics. In: Kalow W (ed.), p. 689–700.

    Google Scholar 

  • Steiner E, Bertilsson L, Säwe J, Bertling I and Sjögvist F (1988). Polymorphic debrisoquine hydroxylation in 757 Swedish subjects. Clin Pharmacol Ther 44:431–435.

    Article  PubMed  CAS  Google Scholar 

  • Tucker GT, Silas JH, Iyun AO, Lennard MS and Smith AJ (1977). Polymorpic hydroxylation of debrisoquine. Lancet 2:718.

    Article  PubMed  CAS  Google Scholar 

  • Vasko MR, Bell RD, Daly DD and Pippenger CE (1980). Inheritance of phenytoin hypometabolism: a kinetic study of one family. Clin Pharmacol Ther 27:96–103.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson GR (1989).Pharmacogenetic factors responsible for variability in drug disposition. In: Breimer DD, Crommelin JJ and Midha KK, (eds) Topics in Pharmaceutical Sciences Fédération Internationale Pharmaceutique, The Hague, pp. 541–554.

    Google Scholar 

  • Wilkinson GR, Guengerich FP and Branch RA (1992). Genetic polymorphism of S-mephenytoin hydroxylation. In: Kalow W (ed.), p. 657–685

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Breimer, D.D. (1994). Genetic polymorphisms in drug metabolism: clinical implications and consequences in ADME studies. In: Walker, S., Lumley, C., McAuslane, N. (eds) The Relevance of Ethnic Factors in the Clinical Evaluation of Medicines. CMR Workshop Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1420-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1420-2_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4621-3

  • Online ISBN: 978-94-011-1420-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics