Skip to main content
SpringerLink
Log in

Prostaglandins and Human Reproduction: Physiological Roles and Clinical Uses of Prostaglandins in Relation to Human Reproduction

  • Chapter
The Prostaglandins

Abstract

The history of prostaglandins is very closely associated with the human reproductive system. What was described as a smooth muscle stimulating substance found in human seminal fluid (Kurzrok and Lieb, 1930; von Euler, 1934, 1935 and Goldblatt 1933), was later shown to consist of a group of modified long chain 20 carbon fatty acids (see Chapter 9 for the Chemistry of Prostaglandins). Subsequent studies have been directed in three main areas.

  1. (1)

    Towards the isolation and identification of prostaglandins in human reproductive organs and in fluids.

  2. (2)

    Towards a study of the pharmacological actions of these compounds on various reproductive organs.

  3. (3)

    Towards establishing physiological roles for prostaglandins in various reproductive processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abrahams, O. L., and Hawkins, D. F. (1967). ‘Lipid-soluble uterine muscle stimulants in human amniotic fluid’, J. Obstet. Gynaec., Br. Commonw., 74, 235–46.

    CAS  Google Scholar 

  • Amersbach, R. (1930). ‘Sterilitat and Frigiditat’, Munch, med. Wschr., 77, 225–7.

    Google Scholar 

  • Anderson, G., Hobbins, J., Cordero, L., and Speroff, L. (1971). ‘Early abortion in the human’, Ana. N.T. Acad. Sci., t8o, 473–82.

    Google Scholar 

  • Asplund, J. (1947). ‘A quantitative determination of the content of contractive substances in human sperm and their significance for the motility and vitality of the spermatozoa’, Acta. Physiol. Scand., 13, 103–8.

    PubMed  CAS  Google Scholar 

  • Barry, A. P., Geoghan, F., and Shea, S. M. (1955). ‘Acquired fibrinopenia in pregnancy’, Br. Med. J., 2, 287–90.

    PubMed  CAS  Google Scholar 

  • Batta, S. K., and Chaudhury, R. R. (1968). The anti-implantation property of intraluminal fluid in rats with an intra-uterine silk thread suture, J. Reprod. Fertil., 16, 145–6.

    PubMed  CAS  Google Scholar 

  • Beazley, J. M. (1971). ‘Prostaglandins in human reproduction’, British J. Hospital Medicine, April 1971, 535–52.

    Google Scholar 

  • Beazley, J. M., Dewhurst, C. J., and Gillespie, A. (1970). ‘Induction of labour with prostaglandin E,’, J. Obstet. Gynaec., Br. Commonw., 77, 193–9.

    CAS  Google Scholar 

  • Beazley, J. M., and Gillespie, A. (1971). ‘Double blind trial of prosta-glandin E, and oxytocin in induction of labour’, Lancet, 1, 152–5.

    PubMed  CAS  Google Scholar 

  • Belonoschkin, B. (1949). ‘Zeugung beim Menschem’ ( Stockholm: Sjöbergs Forlag, 1949 ).

    Google Scholar 

  • Bergström, S., Dressler, F., Krabisch, L., Ryhage, R., and Sjövall, J. (1962). ‘The isolation and structure of a smooth muscle stimulating factor in normal sheep and pig lungs’. Ark. Kemi., 20, 63–6.

    Google Scholar 

  • Bergström, S., Dressler, F., Ryhage, R., Samuelsson, B., and Sjövall, J. (1962). ‘The isolation of two further prostaglandins from sheep prostate glands’, Ark. Kemi., 19, 563–7.

    Google Scholar 

  • Bergström S., and Samuelsson, B. (1962). ‘Isolation of prostaglandin E1 from human seminal plasma’, J. biol. Chem., 237, PC3oo5—PC3oo6.

    Google Scholar 

  • Bergström, S., and Sjövall, J. (1957). ‘The isolation of prostaglandin’, Acta. Chem. Stand., i i, 1086.

    Google Scholar 

  • Bergström, S., and Sjövall, J. (1960). ‘The isolation of prostaglandin from sheep prostate glands’, Acta. Chem. Scand., z4, 1693–1700.

    Google Scholar 

  • Bergström, S.,Sjövall, J. (z960b). ‘The isolation of prostaglandin from sheep prostate glands’, Acta. Chem. Scand., z4, 1701–5.

    Google Scholar 

  • Bickers, W., and Main, R. J. (1941). ‘Patterns of Uterine motility’, 3. Clin. Endocr., z, 992–5.

    Google Scholar 

  • Broesike, G. (1911). ‘Über die Entleerung und Beschaffenheit der menschlichen Samenflüssigkeit’, Arch. mikr. Anat., 78, 128–50.

    Google Scholar 

  • Brummer, H. C. (1971). ‘Interaction of E prostaglandins and syntocinon on the pregnant human myometrium’, J. Obstet. Gynaec., 78, 305–9.

    CAS  Google Scholar 

  • Bygdeman, M. (1964). ‘The effect of different prostaglandins on the human myometrium in vitro’, Acta. Physiol. Scand., 63, Suppl. 242, 1–78.

    Google Scholar 

  • Bygdeman, M. (1967). ‘Studies of the effects of prostaglandins in seminal plasma on human myometrium in vitro’, in Bergstrom S., and Samuelsson, B (eds.), Nobel Symposium 2, Prostaglandins, pp. 71–7 ( Stockholm: Almqvist and Wiksell ).

    Google Scholar 

  • Bygdeman, M., and Eliasson, R. (1963). ‘The effect of prostaglandin from human seminal fluid on the motility of the non-pregnant human uterus in vitro’, Acta. Physiol. Scand., 59, 43–51

    Google Scholar 

  • Bygdeman, M., and Eliasson, R. (1963b). A comparative study on the effect of different prostaglandin compounds on the motility of the isolated human myometrium, Medna exp., 9, 409–15.

    CAS  Google Scholar 

  • Bygdeman, M., Fredricsson, B., Svanborg, K., and Samuelsson, B. (1970). The relation between fertility and prostaglandin content of seminal fluid in man’, Fert. Steril., 21, 622–20.

    CAS  Google Scholar 

  • Bygdeman, M., and Hamberg, M. (1967). The effect of eight new prostaglandins on human myometrium’, Acta. Physiol. Scand., 69, 320–6.

    PubMed  CAS  Google Scholar 

  • Bygdeman, M., Hamberg, M., and Samuelsson, B. (1966). ‘The content of different prostaglandins in human seminal fluid and their threshold doses on the human myometrium’, Mem. Soc. Endocr., 14, 49–64.

    Google Scholar 

  • BYGDEMAN, M., KWON, S. U., MUKHERJEE, T., ROTH-BRANDEL, U., and WIQVIST U., (1970). ‘The effect of the prostaglandin F compounds on the contractility of the pregnant human uterus’, Am. J. Obstet. Gynec., io6, 567–72.

    Google Scholar 

  • Bygdeman, M., Kwon, S. U., Mukherjee, T., and Wiqvist, N. (1968). ‘Effect of intravenous infusion of prostaglandin EI and E2 on the motility of the pregnant human uterus’, Am. y. Obstet. Gynaec., 102, 317–26.

    CAS  Google Scholar 

  • Bygdeman, M., and Samuelsson, B. (1966). ‘Analyses of prostaglandins in human semen’, Clinica. Chim. Acta., 1 3, 465–74.

    Google Scholar 

  • Bygdeman, M., and Samuelsson, B. (1967). ‘Prostaglandins in human seminal plasma and their effects on human myometrium’, Int. J. Fert., 12, 17–20.

    CAS  Google Scholar 

  • Bygdeman, M., and Wiqvist, N. (1971). ‘Early abortion in the human’,Ana. N.r. Acad. Sci., i8o,473–82.

    Google Scholar 

  • Cameron, J. M., and Dayan, A. D. (1966). ‘Association of brain damage with therapeutic abortion induced by amniotic fluid replacement. Report of two cases’, Br. Med.

    Google Scholar 

  • Campbell, B., and Paterson, W. E. (1953). ‘Milk let down and the orgasm in the human female’, Human Biology, 25, 165–8.

    Google Scholar 

  • Chaudhuri, G. (1971). ‘Intrauterine device: possible role of prostaglandins’, Lancet, I, 480.

    PubMed  CAS  Google Scholar 

  • Clitheroe, H. J. (1961). ‘The separation of three plain-muscle stimulants present in the human endometrium’, J. Physiol. Lond., 155, 62–32P.

    Google Scholar 

  • Clitheroe, H. J., and Pickles, V. R. (1961). ‘The separation of the smooth muscle stimulants in menstrual fluid’, y. Physiol. Lond., 156,255–337.

    Google Scholar 

  • Cockrill, J. R., Miller, E. G., and Kurzrok, R. (1935). ‘The substance on human seminal fluid affecting uterine muscle’, Am. J. Physiol., 112, 577–80.

    CAS  Google Scholar 

  • Corbett, H. V. (1958). ‘The management of intrauterine death of the foetus’,.7. Obstet. Gynaec., Br. Commonw.,65 too-5.

    Google Scholar 

  • Coutiho, E. M. (1971). ‘Tubal and uterine motility control of human fertility’, in Diczfalusy, E., and Borell, U (eds.), Nobel Symposium 15, pp. 97–107, 1971

    Google Scholar 

  • Craft, I. L., Cullum, A. R., May, D. T. L., Noble, A. D., and Thomas, D. J. (1971). ‘Prostaglandin E, compared with oxytocin for the induction of labour’, Br. Med. J., 3, 276–9.

    PubMed  CAS  Google Scholar 

  • Doyle, L. L., and Margolis, A. J. (1966). ‘The effect of an IUFB on reproduction in mice’, J. Reprod. Fert., II, 27.

    Google Scholar 

  • Ducharme, D. W., Weeks, J. R., and Montgomery, R. G. (1968). ’Studies on the mechanism of the hypertensive effect of prostaglandin F, y. Pharmac. Exp. There., 160,1–10.

    Google Scholar 

  • Duncan, G. W., and Pharriss, B. B. (1970). ‘Effect of non-steroidal compounds on fertility’, Fedn. Proc. Fedn. Am. Socs. Exp. Biol., 29, 1232–9

    CAS  Google Scholar 

  • Edgar, D. K., and Asdell, S. A. (1960). ‘Spermatozoa in the female genital tract’, J. Endocr., 21, 321–6.

    PubMed  CAS  Google Scholar 

  • Eglinton, G., Raphael, R. A., SMITH, G. N., Hall, W. J.,Pickles, V. R. (1963). ‘The isolation and identification of two smooth muscle stimulents from menstrual fluid’, Nature, Lond., 200, 960, 993–5.

    Google Scholar 

  • Eliasson, R. (1959). ‘Studies on prostaglandin. Occurrence, formation and biological actions’, Acta. Physiol. Scand., 46, Suppl., t58, 1–73.

    Google Scholar 

  • Eliasson, R. (1966). ‘Effect of posterior pituitary hormones on the myo- metrial response to prostaglandin’, Acta. Physiol. Scand., 66, 24.9–50.

    Google Scholar 

  • Eliasson, R., and Posse, N. (1960). ‘The effect of prostaglandin on the non-pregnant human uterus in vivo’, Acta. Obstet. Gynec. Scand., 39, 112–26.

    Google Scholar 

  • Eliasson, R., and Posse, N. (1965). ‘Rubin’s test before and after intra-vaginal application of prostaglandin’, Int. y. Fert., 10, 373–7.

    CAS  Google Scholar 

  • Eliasson, R., and Risley, P. L. (1966). ‘Potentiated response of isolated seminal vesicles to catecholamines and acetylcholine in the presence of PGEI’, Acta. Physiol. Scand., 67, 253–4.

    PubMed  CAS  Google Scholar 

  • Embrey, M. P. (1969). ‘The effect of prostaglandins on the human pregnant uterus’, J. Obstet. Gynaec., Br. Commonw., 76, 783–8.

    Google Scholar 

  • Embrey, M. P. (1970). ‘Induction of labour with prostaglandins EI and E,’, Br. Med. J., 2, 256–8.

    Google Scholar 

  • Embrey, M. P. (1970). ‘Induction of abortion by prostaglandins E1 and E,’, Br. Med. J., 2, 258–60.

    PubMed  CAS  Google Scholar 

  • Embrey, M. P. (1971). ‘PGE compounds for induction of labour and abortion’, Ann. N.Y. Acad. Sci., 18o, 518–23.

    Google Scholar 

  • Embrey, M. P., and Hillier, K. (1971). ‘Therapeutic abortion by intrauterine instillation of prostaglandins’, Br. Med. J., i, 588–90.

    Google Scholar 

  • Embrey, M. P., and Morrison, D. L. (1968). ‘The effect of prostaglandins on pregnant human myometrium in vitro’. J. Obstet. Gynaec., Br. Commonw., 75, 829–832.

    CAS  Google Scholar 

  • Euler, U. S. (1934). ‘Zur Kenntnis der pharmakologischen Wirkungen von Nativsekreten und Extrackten männlicher accessorischer Geschlechtsdrüsen’. Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak., 175, 78–84.

    Google Scholar 

  • Euler, U. S. (1935). ‘Über die spezifische blutdrucksenkende Substanz des menschlichen Prostatata-und Samenblasensekretes’. Klin. Wschr., 14, I182–3.

    Google Scholar 

  • Euler, U. S.(1936). ‘On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)’. J. Physiol. Lond.88, 213–34.

    Google Scholar 

  • Ferraris, F. (1958). Minerva Ginec., 10, 495.

    PubMed  CAS  Google Scholar 

  • Filshie, G. M. (1971). ‘The use of prostaglandin E2 in the management of intrauterine death, missed abortion and hydatidiform mole’, J. Obstet. Gynaec., Br. Commonw., 78, 87–91.

    CAS  Google Scholar 

  • Fitzpatrick, R. J. (1957). ‘On oxytocin and uterine function. The Neurohypophysis’, in Heller, H (ed.), Butterworth’s Scient. Publ., Lond., 202–20.

    Google Scholar 

  • Fox, C. A., Wolff, H. S.,Baker, J. A. (1970). ‘Measurement of intravaginal and intrauterine pressures during human coitus by radio-telemetry’, J. Reprod. Fert., 22, 243–51.

    CAS  Google Scholar 

  • Friberg, O. (1953). ‘Antidiuretic effect of coitus on human subjects’, Acta. Endocr., 12, 193–6.

    Google Scholar 

  • Gillett, P. G., Kinch, R. A. H., Wolfe, L. S., and Pace-Asciak, C. (1971). ‘Therapeutic abortion using prostaglandin F2a’, Amer. J. Obstet. Gynec.,(in press).

    Google Scholar 

  • Goldblatt, M. W. (1933). ‘A depressor substance in seminal fluid’, J. Soc. Chem. Ind., Lond., 52, 1056–7.

    Google Scholar 

  • Goldblatt, M. W. (1935). ‘Properties of human seminal plasma’, J. Physiol., Land., 84, 208–18.

    Google Scholar 

  • Goodlin, R. C. (1969). ‘Orgasm and premature labour’, Lancet, 2, 646.

    PubMed  CAS  Google Scholar 

  • Gutman, E. B., and Gutman, A. B. (1941). ‘Quantitative relations of a prostatic component (acid phosphatase) of human seminal fluid’, Endo-crinology, 28, I 15–8.

    Google Scholar 

  • Gutknecht, G. D., Cornette, J. C., and Pharriss, B. B. (1969). ‘Antifertility properties of prostaglandin F2a’, Biol. Reprod., I, 367–71.

    PubMed  CAS  Google Scholar 

  • Hamberg, M., and Samuelsson, B. (1965). ‘Isolation and structure of a new prostaglandin from human seminal plasma’, Biochim. Biophys. Acta., 106, 215–7.

    PubMed  CAS  Google Scholar 

  • Hamberg, M., and Samuelsson, B. (1966). ‘Prostaglandins in human seminal plasma’, J. Biol. Chem., 241, 257–63.

    Google Scholar 

  • Hamberg, M., and Samuelsson, B. (1967). ‘New groups of naturally occurring prostaglandins’, in Bergström, S., and Samuelsson, B (eds.), Nobel Symposium 2, Prostaglandins, pp. 63–70 ( Stockholm: Almqvist and Wiksell ).

    Google Scholar 

  • Hanon, F., Coquoin-Carnot, M., and Pignard, P. (1955). ‘Le liquide Amniotique’, p. 144, ( Paris: Masson ).

    Google Scholar 

  • Hansen, P. F. (1946). ‘Determination of the “acid” prostatic phosphatase as a new method for the medico-legal demonstration of sperm spots’, Acta. Path. Microbiol. Scand., 23, 187–214.

    CAS  Google Scholar 

  • Harley, G. W. (1941). ‘Native african medicine with special reference to its practice in the Mano tribe of Liberia’, p. 237–8 ( Cambridge, Mass.: Harvard Univ. Press ).

    Google Scholar 

  • Harris, G. W., Pickles, V. R. (1953). ‘Reflex stimulation of the neurohypophysis (posterior pituitary gland) and the nature of posterior pituitary hormone(s)’, Nature, 172, 1049.

    PubMed  CAS  Google Scholar 

  • Hartman, C. G. (1957). How do sperms get into the uterus?, Fertil. and Steril., 8, 403–27.

    CAS  Google Scholar 

  • Hawkins, D. F. (1962). Oxytocic lipids in human amniotic fluid’, Nature, Lord., 194, 975.

    Google Scholar 

  • Hawkins, D. F. (1968). ‘Relevance of prostaglandins to problems of human subfertility’, in Ramwell, P. W., and Shaw, J. E (eds.), Prostaglandin symposium of the Worcester Foundation for Exp. Biol. (New York:

    Google Scholar 

  • Hawkins, D. F., and Labrum, A. H. (1956). ‘Function of the prostate’, Br. Med. J., 2, 1236.

    Google Scholar 

  • Hillier, K. (1970). ‘Occurrence and actions of some prostaglandins in human umbilical and placental blood vessels’, Ph.D. Thesis (University of London).

    Google Scholar 

  • Hillier, K., and Karim, S. M. M. (1968). ‘Effects of prostaglandins E1, E2, Fla and Fla on isolated human umbilical and placental blood vessels’, J. Obstet. Gynaec., Br. Commonw., 75, 667–74.

    CAS  Google Scholar 

  • Hodgkinson, C. P., Margulis, R. R., and Lazarde, J. H. (1954). ‘Etiology and management of hypofibrinogenaemia of pregnancy’, J.A.M.S.

    Google Scholar 

  • Holmes, S. W., Horton, E. W., and Main, I. H. M. (1963). ‘The effect of prostaglandin E1 on responses of smooth muscle to catecholamines, angiotensin and vasopressin’, Br. J. Pharmac. Chemother., 21, 538–43.

    CAS  Google Scholar 

  • Horn, H. W., and Thibault, J. P. (1962). ‘Sperm migration through the human female reproductive tract’, Fertil. Steril., 13, 135–9.

    Google Scholar 

  • Horton, E., Jones, R., Thompson, C., and Poyser, M. (1971). ‘Release of prostaglandins’, Ann. N.Y. Acad. Sci., 180, 351–62.

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M. (1966). ‘A smooth muscle contracting substance in extracts of human umbilical cord’, J. Pharm. Pharmac., 18, 519–30.

    Google Scholar 

  • Karim, S. M. M. (1966). ‘Identification of prostaglandins in human amniotic fluid’, J. Obstet. Gynaec., Br. Commonw., 73, 903–8.

    CAS  Google Scholar 

  • Karim, S. M. M. (1967). ‘The identification of prostaglandins in human umbilical cord’, Br. y. Pharmac. Chemother., 29, 230–7.

    CAS  Google Scholar 

  • Karim, S. M. M. (1968). ‘Appearance of prostaglandin Fla in human blood during labour’, Br. Med. J., 4, 618–21.

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M. (1969). ‘The role of prostaglandin Fla in human parturition’, in Mantegazza, P., and Horton, E. W (eds.), Prostaglandins, Peptides and Amines, pp. 65–72 ( London: Academic Press ).

    Google Scholar 

  • Karim, S. M. M. (1969). ‘Effect of some prostaglandins on the pregnant human myometrium in vivo’, Abstracts, 4th Int. Congr. Pharmac., Basle, P. 337.

    Google Scholar 

  • Karim, S. M. M. (1970). ‘The use of prostaglandin E2 in the management of missed abortion, missed labour and hydatidiform mole’, Br. Med. J., 3, 196–7.

    Google Scholar 

  • Karim, S. M. M. (1970). ‘Prostaglandins and reproductions’, in Macdonald, R. R (ed.), Scieniic basis of Obstetrics and Gynaecology, 315–46 ( London: Churchill ).

    Google Scholar 

  • Karim, S. M. M. (1971). ‘The role of prostaglandins in human parturition’, Proc. Roy. Soc. Med. Meeting firth November, 1969, 64, I I.

    Google Scholar 

  • Karim, S. M. M. (1971). ‘Action of prostaglandin in the pregnant woman’, Ann. N.Y. Acad. Sci., i8o, 483–98.

    Google Scholar 

  • Karim, S. M. M. (1971). ‘Effects of oral administration of prostaglandin Es and F2. on the human uterus’, J. Obstet. Gynaec., Br. Commonw., 78, 289–93.

    CAS  Google Scholar 

  • Karim, S. M. M. (1971). ‘The use of prostaglandins in abortion’. Proceedings of the Conference on Abortion Techniques and Services, New York, June 1971. American Journal of Public Health (in press).

    Google Scholar 

  • Karim, S. M. M. (1971e). ‘Once-a-month vaginal administration of prostaglandins E2 and Fla for fertility control’, Contraception, 3, 173–83.

    CAS  Google Scholar 

  • Karim, S. M. M., and Devlin, J. (1967). ‘Prostaglandin content of amniotic fluid during pregnancy and labour’, J. Obstet. Gynaec., Br. Commonw., 74

    Google Scholar 

  • Karim, S. M. M., Filshie, G. M. (1970). ‘Therapeutic abortion using prostaglandin F28’, Lancet, I, 157–9.

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M., Filshie, G. M. (1970). ‘Use of prostaglandin E2 for therapeutic abortion’, Br. Med. J., 3, 198–200.

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M., Filshie, G. M., and Clayton, S. (1971). ‘A study in the use of prostaglandin E2 for therapeutic abortion’. Accepted 1971, J. Obstet. Gynaec., Br. Commonw.

    Google Scholar 

  • Karim, S. M. M., Hillier, K. (1970). ‘Prostaglandins and spontaneous abortion’, J. Obstet. Gynaec., Br. Commonw., 77, 837–9.

    CAS  Google Scholar 

  • Karim, S. M. M., Hillier, K., Trussell, R. R., Patel, R. C., and Tamusange, S. (1970). ‘Induction of labour with prostaglandin E2’, J. Obstet. Gynaec., Br. Commonw., 77, 200–10.

    CAS  Google Scholar 

  • Karim, S. M. M., Hillier, K., Somers, K., and Trussell, R. R. (1971). ‘The effects of prostaglandins E2 and Fla administered by different routes on uterine activity and the cardiovascular system in pregnant and non-pregnant women’, J. Obstet. Gynaec., Br. Commonw., 78, 172–9.

    CAS  Google Scholar 

  • Karim, S. M. M., Patel, R. C., Sharma, S. D., and Trussell, R. R. (1971). ‘Two years experience of prostaglandin E2 for the induction of labour’, J. of the Asian Federation of Obstet. and Gynaec. (Accepted 1971).

    Google Scholar 

  • Karim, S. M. M.,Sharma, S. D. (1971). ‘Second trimester abortion with single intra-amniotic injection of prostaglandins E2 or F22’, Lancet, 2, 47–8.

    PubMed  CAS  Google Scholar 

  • Karim, S. M. M., Sharma, S. D. (1971). ‘Therapeutic abortion and induction of labour by the intravaginal administration of prostaglandin E2 and F28’, J. Obstet. Gynaec., Br. Commonw., 78, 294–300.

    CAS  Google Scholar 

  • Karim, S. M. M.,Sharma, S. D. (1971). ‘Oral administration of prostaglandins for the induction of labour’, Br. Med. J., i, 260–2.

    Google Scholar 

  • Karim, S. M. M.,Sharma, S. D. (1971). ‘Induction of labour with intra-amniotic prostaglandins’ (in press).

    Google Scholar 

  • Karim, S. M. M., and Sharma, S. D. (1971). ‘Prostaglandins in amniotic fluid during different stages of labour’ (in press).

    Google Scholar 

  • Karim, S. M. M., Sharma, S. D. (1971). ‘The effect of ethyl alcohol on prostaglandins E2 and Fla induced uterine activity in pregnant women’, J. Obstet. Gynaec., Br. Commonw., 78, 251–4.

    CAS  Google Scholar 

  • Karim, S. M. M., Somers, K., and Hillier, K. (1971). ‘Cardiovascular and other effects of prostaglandins E2 and Fla in man’, Cardiovascular research, July 1974 5, 255–61.

    Google Scholar 

  • Karim, S. M. M., and Trussell, R. R. (1971). ‘The use of prostaglandins in Obstetrics’, East African Med. y., 48, I-12.

    Google Scholar 

  • Karim, S. M. M., Trussell, R. R., Patel, R. C., and Hillier, K. (1968). ‘Response of pregnant human uterus to prostaglandin Fla induction of labour’, Br. Med. y., 4, 621–3.

    CAS  Google Scholar 

  • Karim, S. M. M., Trussell, R. R., Hillier, K., and Patel, R. C. (1969). ‘Induction of labour with prostaglandin Fu’, J. Obstet. Gynaec., Br. Commonw., 76, 769–82.

    Google Scholar 

  • Karlson, S. (1959). ‘The influence of seminal fluid on the motility of the non-pregnant human uterus’, Acta. Obstet. Gynec. Scand., 38, 503–21.

    PubMed  CAS  Google Scholar 

  • Kaufman, R. G., Freeman, R. K., and Mishell, D. R. (1971). ‘Abortifacient activity of intravenously administered prostaglandins’, Contraception, 3, 121–32.

    Google Scholar 

  • Khew, K. S., Ratnam, S.> S., Chen, C., LIM, T. C., and Karim, S. M. M (1971). ’Induction of labour with oral prostaglandin E2 (in press).

    Google Scholar 

  • Kirton, K. T., Pharriss, B. B., Forbes, A. D. (1970). ‘Luteolytic effects of prostaglandin Fla in primates’, Proc. Soc. Exp. Biol. Med., 133, 314–6.

    PubMed  CAS  Google Scholar 

  • Kurzrok, R., and Lieb, C. C. (1930). ‘Biochemical studies of human semen. II. The action of semen on the human uterus’, Proc. Soc. Exp. Biol. (N. r.), 28, 268–72.

    Google Scholar 

  • Loudon, J. D. O. (1959). ‘The use of high concentration oxytocin intravenous drip in the management of missed abortion’, J. Obstet. Gynaec., Br. Emp., 66, 277–81.

    Google Scholar 

  • Lundqvist, F. (1949). ‘Aspects of the biochemistry of human semen’, Acta. Physiol. Scand., 19, Suppl. 66.

    Google Scholar 

  • Mantegazza, P. C., and Kabir Naimzada, M. (1965). ‘Attività della prostaglandina EI sul preparato nervo ipogastrico-deferente di varie specie animali’, Atti. Accad. Med. Lomb., 20, 58–64.

    PubMed  CAS  Google Scholar 

  • Martin, R. H., and Menzies, D. N. (1955). ‘Oestrogen therapy in missed abortion’, J. Obstet. Gynaec., Br. Emp., 62, 256–61.

    CAS  Google Scholar 

  • Masters, W. H., and Johnson, V. E. (1966). ’Human sexual response ( Boston, Mass.: Little and Brown).

    Google Scholar 

  • Najai, Z., Hillier, K., and Karim, S. M. M. (197o). ‘The action of prostaglandins on the human isolated non-pregnant cervix’, J. Obstet. Gynaec.Br. Commonw701–9.

    Google Scholar 

  • Neill, J. D., Jghansson, E. D. B., and Knobil, E. (1969). ‘Failure of hysterectomy to influence the normal pattern of cycle progesterone secretion in the rhesus monkey’, Endocrin., 84, 464–5.

    CAS  Google Scholar 

  • Nugteren, D. H., Beerthuis, R. K., and Van Dorp, D. A. (1966). ‘The enzymic conversion of all-cis 8, 14.-eicosatrienoic acid into prostaglandin EI’, Red. Trail. Chim., Pays-Bas Belg., 85, 405–19.

    CAS  Google Scholar 

  • O’driscoll, D. T., and Lavelle, S. M. (1955). ‘Blood coagulation defect associated with missed abortion’, Lancet, 2, 1169–72.

    Google Scholar 

  • Pharriss, B. B. (1969). ‘The possible vascular regulation of luteal function’, Perspect. Biol. Med., 13, 434–44.

    Google Scholar 

  • Pharriss, B. B., Cornette, J. C., and Gutknecht, G. D. (1970). ‘Vascular control of luteal steroidogenesis’, 3. Reprod. Fert. Suppl., Io, 97–103.

    Google Scholar 

  • Pharriss, B. B., and Wyngarden, L. J. (1969). ‘The effect of prostaglandin Fla on the progestogen content of ovaries from pseudo-pregnant rats’, Proc. Soc. Exp. Biol. Med., 130, 92–4.

    Google Scholar 

  • Pickles, V. R. (1953). ‘Blood-flow estimations as indices of mammary activity’, J. Obstet. Gynaec., Br. Emp., 60, 302–12.

    Google Scholar 

  • Pickles, V. R. (1957). ‘A plain muscle stimulant in the menstrual fluid’, Nature, Lond., 1198–9.

    Google Scholar 

  • Pickles, V. R. (1967). ‘The prostaglandins’, Biol. Rev., 42, 614–52.

    Google Scholar 

  • Pickles, V. R., and Hall, W. J. (1963). ‘Some physiological properties of the “menstrual stimulant” substances AI and A,’,,. Reprod. Fert., 6, 315–7.

    Google Scholar 

  • Pickles, V. R., Hall, W. J., Best, F. A., and Smith, G. N. (1965). ‘Prostaglandins in endometrium and menstrual fluid from normal and dysmenorrhoeic subjects’,,. Obstet. Gynaec., Br. Commonw., 72, 185–92.

    Google Scholar 

  • Pickles, V. R., Hall, W. J., Clegg, P. C., and Sullivan, T. J. (1966). ‘Some experiments on the mechanism of action of prostaglandin on the guinea-pig and rat myometrium’, Mem. Soc. Endocr., 14, 89–103.

    Google Scholar 

  • Pickles, V. R., and Ward, P. F. V. (1965). ‘Menstrual stimulant component B, and possible prostaglandin precursors in the endometrium’, J. Physiol. Lond., 178, 38P - 39 P.

    CAS  Google Scholar 

  • Pritchard, J. A.,Ratnoff, O. D. (1955). ‘Studies of fibrinogen and other haemostatic factors in women with intrauterine death and delayed delivery’, Surgery, Gynaecology and Obstetrics, 1OI, 467–77.

    Google Scholar 

  • Quinn, L. J., and Harper, J. A. (1955). ‘Fibrinogenaemia in an isosensitized mother carrying a dead foetus’, J. Obstet. Gynaec, Br. Emp., 62, 280–2.

    CAS  Google Scholar 

  • Roberts, G., and Turnbull, A. C. (1971). ‘Uterine hypertonus during labour induced by prostaglandins’, Br. Med. J., I, 702–5.

    Google Scholar 

  • Robinson, A. L., Datnow, M. M., and Jeffcoate, T. N. A. (1935). ‘Induction of abortion and labour by means of oestrin’, Br. Med. J., I, 749–53.

    PubMed  CAS  Google Scholar 

  • Roth-Brandel, U., and Adams, M. (1970). ‘An evaluation of the possible use of prostaglandin EI, E2 and Fla for induction of labour’, Acta. Obstet. Gynec. Scand., 49, Suppl. 5, 9–17.

    Google Scholar 

  • Roth-Brandel, U., Bygdeman, M., and Wiqvist, N. (197oa). ‘Effect of intravenous administration of prostaglandin EI and Fla on the con-tractility of the non-pregnant human uterus in vivo’, Acta. Obstet. Gynec. Scand., 49, Suppl., 5, 19–25.

    Google Scholar 

  • Roth-Brandel, U., Bygdeman, M., and Wiqvist, N. (1970). ‘A comparative study on the influence of prostaglandin E1, oxytocin and ergometrine on the pregnant human uterus’, Acta. Obstet. Gynec. Scand., 49, Suppl., 5,1–7.

    Google Scholar 

  • Roth-Brandel, U., Bygdeman, M., Wiqvist, N., and Bergström, S. (1970). ‘Prostaglandins for induction of therapeutic abortion’

    Google Scholar 

  • Samuelsson, B. (1963). ‘Prostaglandins of human seminal plasma’,Biochem. y., 89 34P.

    Google Scholar 

  • Samuelsson, B. (1963). ‘Isolation and identification of prostaglandins from human seminal plasma’, y. Biol. Chem., 238, 3229–34.

    Google Scholar 

  • Samuelsson, B. (1964). ‘Synthesis of tritium-labeled prostaglandin E1 and studies on its distribution and secretion in the rat’, y. Biol. Chem., 239, 4091–6.

    Google Scholar 

  • Samuelsson, B. (1964). ‘The identification of prostaglandin Fia in bovine lung’, Biochim. Biophys. Acta., 84, 707–13.

    PubMed  CAS  Google Scholar 

  • Sandberg, F., Ingelman-Sundberg, A., and Rydén, G. (1963). ‘The effect of purified prostaglandin E1 on the human uterus and tubes’, Int. J. Fert., 8, 869.

    Google Scholar 

  • Sandberg, F., Ingelman-Sundberg, A., and Rydén, G. (1963). ‘The effect of prostaglandin E1 on the human uterus and the fallopian tubes in vitro’, Acta. Obstet. Gynec. Scand., 42, 269–78.

    Google Scholar 

  • Sandberg, F., Ingelman-Sundberg, A., and Rydén, G. (1964). ‘The effect of prostaglandin E, and E3 on the human uterus and fallopian tubes in vitro’, Acta. Obstet. Gynec. Scand., 43, 95–102.

    Google Scholar 

  • Sandberg, F., Ingelman-Sundberg, A., and Rydén, G. (1965). ’The effect of prostaglandin Fla, F 1ß and F2ß on the human uterus and the fallopian tubes in 94.

    Google Scholar 

  • Sandberg, F., Ingelman-Sundberg, A., Rydén, G., and Joelsson, I. (1968). ‘The absorption of tritium-labelled prostaglandin E1 from the vagina of non-pregnant women’, Acta. Obstet. Gynec. Scand., 47, 22–6.

    PubMed  CAS  Google Scholar 

  • Toaff, R., and Ayalon, D. (1962). ‘Treatment of missed abortion and hydatidiform mole by high concentration oxytocin infusion’, Obstetrics and Gynaecology, 19, 81–6.

    CAS  Google Scholar 

  • Trapl, J. (1943). ‘Neue Anschauungen Über den Ei-und Samentransport in den inneren Geschlechtsteilen der Frau’, Zbl. Gynak, 6 7, 547–50.

    Google Scholar 

  • Wagatsuma, T. (1965). ‘Intra-amniotic injection of saline for therapeutic abortion’, Am. y. Obstet. Gynecol., 93, 743–5.

    Google Scholar 

  • Wiqvist, N., Bygdeman, M., Kwon, S. U., Mukherjee, T., and Rothbrandel, U. (1968). ‘Effect of prostaglandin E1 on the midpregnant human uterus’, Am. y. Obstet. Gynecol., 102, 327–32.

    CAS  Google Scholar 

  • Wiqvist, N., and Bygdeman, M. (1970). ‘Induction of therapeutic abortion with intravenous prostaglandin F2a’, Lancet, i, 889.

    Google Scholar 

  • Wiqvist, N., Bygdeman, M., and Kirton, K. T. (1971). ‘Non-steroidal antifertility agents in the female’, Trans. of XV Nobel Sympos. 137–55.

    Google Scholar 

  • Wolff, H. S. (1961). ‘The radio pill’, New Scient., 12, 419.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Makerere University Medical School, Kampala, Uganda

    Sultan M. M. Karim (Professor and Head)

Authors
  1. Sultan M. M. Karim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Makerere University Medical School, Kampala, Uganda

    Sultan M. M. Karim Ph.D. (Professor and Head) (Professor and Head)

Rights and permissions

Reprints and permissions

Copyright information

© 1972 MTP, Medical and Technical

About this chapter

Cite this chapter

Karim, S.M.M. (1972). Prostaglandins and Human Reproduction: Physiological Roles and Clinical Uses of Prostaglandins in Relation to Human Reproduction. In: Karim, S.M.M. (eds) The Prostaglandins. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9697-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9697-3_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9699-7

  • Online ISBN: 978-94-010-9697-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation