Abstract
This paper introduces a strategy for integrating the functions of mammalian cells with electrodes. The strategy is based on the use of self-assembled monolayers of alkanethiolates on gold that present ligands for the adhesion of cells. The monolayers have been engineered such that applied potentials result in the modulation of ligand activities at the substrate and a corresponding influence over the behavior of attached cells. Early examples have demonstrated electroactive substrates that can turn on the migration of cells and that can release adherent cells. These examples represent a general route to integrating electrical processes with cellular processes.
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References
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© 2001 Springer Science+Business Media New York
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Mrksich, M. (2001). Engineering Active Interfaces between Cells and Electronics. In: Ramsey, J.M., van den Berg, A. (eds) Micro Total Analysis Systems 2001. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1015-3_2
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DOI: https://doi.org/10.1007/978-94-010-1015-3_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3893-5
Online ISBN: 978-94-010-1015-3
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