Abstract
Subgroup questions include:
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Who has unusual large response? Is such occurrence associated with subgroups of patients?
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they can be used for refining patient- or dose-selection for future trials.
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Subgroup-analyses are -by nature- almost surely underpowered to definitely answer the above questions and therefore hypothesis generating rather than hypothesis confirming.
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© 2002 Springer Science+Business Media New York
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Cleophas, T.J., Zwinderman, A.H., Cleophas, T.F. (2002). Subgroup Analysis Using Regression Modeling. In: Statistics Applied to Clinical Trials: Self-Assessment Book. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0285-1_10
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DOI: https://doi.org/10.1007/978-94-010-0285-1_10
Publisher Name: Springer, Dordrecht
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