Skip to main content

The Role Of Enculturation in Scientific Innovation: A Case Study of Combinatorial Chemistry at Parke-Davis

  • Chapter
Scientific Research Effectiveness

Abstract

Every scientific organization has a culture that characterizes its particular values and modes of working. To be successful, the types of problems addressed by innovators within the organization must be consonant with corporate culture, as must be the solutions achieved. There are thus two levels of organization that need to be considered concurrently in evaluating an organisation’s potential for innovation. One is the organisational culture that exists at the level of the research laboratory, which is dependent upon interactions of a small group of scientists and their manager. The other is the organisational culture of the corporation as a whole, which is often expressed most clearly in the policies and decisions of upper management, but which may also be observed in the interactions between one laboratory and others within an institution. The culture that exists within an individual laboratory group may or may not fit well within the broader institutional culture. The problems generated and developed by individual laboratories therefore pose critical tests of the overall potential that an organization has for innovation. Individual scientists, or small group of scientists, may generate research problems that may or may not fit the particular problems that need to be addressed by the dominant corporate culture. Those who conform to the culture and address its problems tend to preserve that culture. The way in which an organization handles unexpected problems and the oddballs who generate them, determines the potential for innovation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Braben, D., (1994). To be a scientist. Oxford: Oxford University Press.

    Google Scholar 

  • Caldwell, J. W. (1999). Quarterly U. S. patent review: First quarter Biotechnology and Bioengineering, 61, 189-90.

    Article  Google Scholar 

  • Comroe, J. H. Jr., & Dripps, R. D. (1981). Scientific Basis for the Support of Biomedical Science. In E. B. Roberts, R. I. Levy, S.N. Finkelstein, J. Moskowitz, & E. J. Sondick (Eds.), Biomedical innovation(pp. 101-122). Cambridge MA: MIT Press.

    Google Scholar 

  • Danielli, J. F. (1966). What special units should be developed for dealing with the life sciences and what specializations of program are most likely to be needed in the future? In: Anon. (Eds.) The future of biology. (pages 90-116). New York: SUNY Press.

    Google Scholar 

  • DeWitt, S. Hobbs, Kiely, J. S., Stankovic, C. J., Schroeder, M. C, Cody, D. M. R., & Pavia, M. R. (1993). Diversomers: An approach to nonpeptide, non-oligomeric chemical diversity. Proceedings of the National Academy of Sciences, USA90, 6906-6913.

    Article  Google Scholar 

  • Faust, Richard E. (1981). The role of the pharmaceutical industry in collaborative research: The Calcitriol story. In E. B. Roberts, R. I. Levy, S.N. Finkelstein, J. Moskowitz, & E. J. Sondick (Eds.), Biomedical innovation(pp. 144-151). Cambridge MA: MIT Press.

    Google Scholar 

  • Ganem, B., (n.d.). Entrepreneurship in chemical enterprise: Course materials for chemistry 404. (Available frombganem@cornell.edu).

    Google Scholar 

  • Halacy, D. S. Jr., (1967). Science and serendipity: Great discoveries by accident. Philadelphia: Lippincott.

    Google Scholar 

  • Hower, R. M., & Orth, C. D. (1963). Managers and scientists: Some human problems of industrial research organizations. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Houghton, R. A. (2000). Parallel array and mixture-based synthetic combinatorial chemistry: tools for the next millennium. Annual Review of Pharmacology and Toxicology40, 273-282.

    Article  Google Scholar 

  • Hounshell, David A. (1992). “Invention in the industrial research laboratory: Individual act or collective process?” In R. J. Weber, & D.N. Perkins (Eds.). Inventive minds: Creativity in technology, (pp. 273-290). Oxford: Oxford University Press.

    Google Scholar 

  • Kuhn, T. S. (1959). The structure of scientific revolution. Chicago: University of Chicago Press.

    Google Scholar 

  • Pavia, M. (1994). The chemical generation of molecular diversity. Available from http://www.netsci.org/Science/Combichem/feature01.html.

    Google Scholar 

  • Pelz, D. C., & Andrews, F. M. (1966). Scientists in organizations: Productive climates for research and development. New York: John Wiley.

    Google Scholar 

  • Roberts, E. B. (1981). Influences on innovation: Extrapolations to biomedical technology. In E. B. Roberts, R. I. Levy, S.N. Finkelstein, J. Moskowitz, & E. J. Sondick (Eds.), Biomedical innovation(pp. 51-74). Cambridge MA: MIT Press.

    Google Scholar 

  • Roberts, E. B., Levy, R. I., Finkelstein, S. N., Moskowitz, J., & Sondick E. J. (Eds.). (1981). Biomedical innovation. Cambridge MA: MIT Press.

    Google Scholar 

  • Root-Bernstein, R. S. (1982). The problem of problems. Journal of Theoretical Biology, 99, 193-201.

    Article  Google Scholar 

  • Root-Bernstein, R. S. (1988). Setting the stage for discovery. The Sciences, May/June, 26-35.

    Google Scholar 

  • Root-Bernstein, R. S. (1989). Discovering, inventing and solving problems at the frontiers of science. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Root-Bernstein, R. S. (1990). Who discovers and invents. Research-Technology Management, 32, 43-48.

    Google Scholar 

  • Root-Bernstein, R. S. (1990). Strategies of research.Research-Technology Management, 32, 36-42.

    Google Scholar 

  • Root-Bernstein, R. S. (1994). Fostering exploratory research. R&D Innovator, 3 (5),1-3.

    Google Scholar 

  • Root-Bernstein, R. S. (1994). The discovery process. Chemtech, May, 15-20.

    Google Scholar 

  • Root-Bernstein, R. S. (1995). Fostering innovative decision-making through leadership. R&D Innovator, 4 (9),1-4.

    Google Scholar 

  • Root-Bernstein, R. S. (1999). Discovery. In M. A. Runco & S. R. Pritzker(Eds.), Encyclopedia of creativity: Vol. 1 A-H(pp. 559-571). New York: Academic Press.

    Google Scholar 

  • Root-Bernstein, R. S.(in press). Nepistemology: Problem generation and evaluation. In L. Shavanina, (Ed.), The International Handbook on Innovation.

    Google Scholar 

  • Weber, R. J., & Perkins, D. N. (1992). Inventive minds: Creativity in technology. Oxford: Oxford University Press.

    Google Scholar 

  • Weisbach, J. A., & Moos, W. H. (1995). Diagnosing the decline of major pharmaceutical research laboratories: A prescription for drug companies. Drug Development Research, 34, 243-259.

    Article  Google Scholar 

  • Wise, George. 1992. Inventors and corporations in the maturing electrical industry: 1890-1940 In Weber and Perkins,). Inventive minds: Creativity in technology. Oxford: Oxford University Press. pp. 291-310.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Root-Bernstein, R. (2003). The Role Of Enculturation in Scientific Innovation: A Case Study of Combinatorial Chemistry at Parke-Davis. In: Hurley, J. (eds) Scientific Research Effectiveness. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0275-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-0275-2_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3961-1

  • Online ISBN: 978-94-010-0275-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics