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Toward an understanding of the multiplicity of glucocorticoid actions on brain function and behaviour

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Hormones and the Brain

Abstract

Glucocorticoids have a multiplicity of effects on brain biochemistry, neural excitability and behaviour. This article attempts to relate certain of the biochemical and neurological effects of glucocorticoids to some of the behavioural actions related to extinction of learned behaviour and retrograde amnesia, as well as to behaviours related to function of the hippocampus. It is suggested from this analysis that there is no unitary biochemical mechanism for these various glucocorticoid effects.

We summarize in greater detail progress in one of the more fruitful lines of biochemical investigation of glucocorticoid action in the nervous system, namely, the study of the neural receptor sites for this class of hormones. These studies have focused on the limbic system, and especially the hippocampus, as the major neuronal glucocorticoid target sites of the central nervous system. We attempt to relate findings regarding receptors to recent studies which implicate a role for adrenocortical secretion in behaviours which are dependent upon hippocampal function.

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  1. The Rockefeller Universiy, 10021, 1230 York Avenue, New York, NY, USA

    Dr B. S. McEwen

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McEwen, B.S., Micco, D.J. (1980). Toward an understanding of the multiplicity of glucocorticoid actions on brain function and behaviour. In: Hormones and the Brain. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8709-8_2

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  • DOI: https://doi.org/10.1007/978-94-009-8709-8_2

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