Abstract
Animals in early developmental stages differ substantially from their mature counterparts in susceptibility to the adverse effects of xenobioticsIn the response to some agents that require biotransformation for activity, developing animals can be more resistant than adults because of undeveloped xenobiotic biotransformation enzyme systemsMore often, developing animals are more sensitive to adverse effects because of one or more of several characteristics, including undeveloped xenobiotic detoxification enzyme systems, vulnerability of replicating cells to injury, susceptibility of regulatory systems to modulation and susceptibility of systems concerned with differentiated function.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boreus, LO(ed.) (1973)Fetal Pharmacology( New York: Raven Press )
Dun, TBand Green, AW(1963)Cysts of the epididymis, cancer of the cervix, granular cell myoblastoma, and other lesions after estrogen injection in newborn miceJNatlCancer Inst, 31, 425 – 55
Einarson, K., Gustafsson, Jand Stenberg, A(1973)Neonatal imprinting of liver microsomal hydroxylation and reduction of steroidsJ Biol Chem, 248, 4987 – 97
Forsberg, JG(1974)Induction of condition leading to cancer in the genital tract by estrogen during the differentiation phase of the genital epitheliumAdv Biosci, 13, 139 – 51
Green, TP., O’Dea, RFand Mirkin, BL(1979)Determinants of drug disposition and effect in the fetusAnn Rev Pharmacol Toxicol, 19, 285 – 322
Hafez, ESE(ed.) (1970)Reproduction and Breeding Techniques for Laboratory Animals( Philadelphia: Lea and Febiger )
Hartiala, K(1973)Metabolism of hormones, drugs and other substances by the gut– Physiol Rev, 53, 496 – 534
Hook, JBand Bailie, MD(1979)Perinatal renal pharmacologyAnn Rev Pharmacol Toxicol, 19, 491 – 509
Juchau, MR(1980)Drug biotransformation in the placentaPharmac Ther, 8, 501 – 24
Juchau, MR., Chao, ST and Omiecinski, CJ(1980)Drug metabolism by the human fetusClin Pharmacokinet, 5, 320 – 39
Junod, AFand de Haller, R(eds.) (1975)Lung Metabolism( New York: Academic Press )
Kirchgessner, M., Friesecke, Hand Koch, G(1967)Nutrition and the Composition of Milk( Philadelphia and Toronto: JBLippincott )
Knowles, JA(1965)Excretion of drugs in milk – a reviewPediatr Pharmacol Ther, 66, 1068–82
Lucier, GW., Lui, EMK and Lamartiniere, CA(1979)Metabolic activation/deacti– vation reactions during perinatal developmentEnvironHealth Perspect, 29, 7 – 16
Lucier, GW(1976)Perinatal development of conjugative enzyme systemsEnvironHealth Perspect, 18, 25–34,
La Du, BN., Mandel, HG and Way, CL(eds.) (1971)Fundamentals of Drug Metabolism and Drug Disposition( Baltimore: Williams and Wilkins )
Michael, WRand Wakim, JW(1971)Metabolism of nitrilotriacetic acid (NTA)Toxicol Appl Pharmacol, 18, 407 – 16
Rice, JM(ed.) (1979)Perinatal Carcinogenesis National Cancer Institute Monograph 51, US Department of Health Education and Welfare
Rustia, Mand Shubik, P(1979)Effects of transplacental exposure to diethylstilbestrol on carcinogenic susceptibility during postnatal life in hamsterCancer Res, 39, 4636 – 44
Scheline, RR(1973)Metabolism of foreign compounds by gastrointestinal microorganismsPharmacol Rev, 25, 451 – 523
Szeto, HH(1982)Pharmacokinetics in the ovine maternal–fetal unitAnn Rev Pharmacol Toxicol, 22, 221 – 43
Tomatis, L., Turusov, Vand Guibbert, D(1972)Prenatal exposure to chemical carcinogens In Nakahara, W., Takayama, S., Sugimura, Tet al(eds.) Topics in Chemical Carcinogenesis, pp445 – 61( Baltimore: University Park Press )
Toth, B(1968)A critical review of experiments in chemical carcinogenesis using newborn animalsCancer Res, 28, 727 – 38
Ullberg, S., Lindquist, NGand Sjostrand, SE(1970)Accumulation of chorioretino– toxic drugs in the foetal eyeNature (London), 111, 1257 – 8
Weisburger, JHand Williams, GM(1980)Chemical carcinogensIn Amdur, MO., Doull, Jand Klaassen, CD(eds.) Toxicology, The Basic Science of Poisons2nd Edn., pp84 – 138( New York: Macmillan )
Weisburger, JHand Williams, GM(1982)Metabolism of chemical carcinogensIn Becker, FF(ed.) Cancer: A Comprehensive Treatise2nd Edn., pp241 – 333( New York: Plenum Press ).
Weisburger, EK., Yamamoto, RS., Glass, RM., Grantham, PHand Weisburger, JH(1968)Effect of neonatal androgen and estrogen injection on liver tumor induction by N–hydroxy–7V–2–fluorenylacetamide and on the metabolism of the carcinogen in ratsEndocrinology, 82, 685 – 92
Wold, JSand Turnipseed, SA(1978)Age–dependent renal accumulation of cephalori– dine in the rabbitDrug Metab Dispos, 6, 87 – 90
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 MTP Press Limited
About this chapter
Cite this chapter
Williams, G.M. (1983). Drug effects during development and carcinogenicity. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_7
Download citation
DOI: https://doi.org/10.1007/978-94-009-6604-8_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6606-2
Online ISBN: 978-94-009-6604-8
eBook Packages: Springer Book Archive