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Ruminal influences on drug action

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Veterinary Pharmacology and Toxicology

Abstract

Oral administration of drugs to ruminant animals has had a chequered history. It might be summed up as having involved a lot of speculative uncontrolled clinical use and little science. As a result, there has been little evidence of efficacy, a substantial incidence of iatrogenic disease added as a tax on any pre–existing ailments, and a considerable amount of ineffectual waste. Consequently, it is a thankless task to review the current status of the pharmacology of drugs entering the rumen. It is more important to focus on the nature of the biological systems that interact with chemicals introduced to the rumen so that some relevant principles can be identified. Above all, it is necessary to stress the urgency of the need for more sophisticated pharmacological research in diseased animals followed by properly designed clinical trials on drugs for oral use in ruminants.

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Authors
  1. R. H. Dunlop
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Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Dunlop, R.H. (1983). Ruminal influences on drug action. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_16

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

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