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Effects of Localized and Disseminated Cancers on Metabolism and Nutrition in Man

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Etiology of Cancer in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 6))

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Abstract

A number of common metastatic cancers are associated with marked weight loss at the time of diagnosis. Cancer patients with weight loss at the time of diagnosis have decreased mean survival compared to similar cancer patients without weight loss. Provision of excess calories alone does not appear to change median survival in patients with advanced cancer and many patients either maintain body weight or lose weight while receiving calories which would be predicted to result in weight gain. We have recently extended our studies to head and neck cancer patients without detectable metastatic disease in order to detect systemic metabolic effects of a localized tumor. These patients failed to gain weight despite the administration of apparently adequate calories by continuous enteral alimentation. Abnormalities of carbohydrate metabolism with secondary effects on fat and protein metabolism have been identified in several populations of patients with common cancers. These abnormalities offer potential points of intervention which may enhance nutritional therapy as rehabilitation and as a potential biological modifier of the response of specific cancers to chemotherapy, radiation therapy or surgery.

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Authors
  1. David Heber
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  2. Lauri O. Byerley
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Editor information

Editors and Affiliations

  1. National Institutes of Child Health & Human Development, National Institutes of Health, Bethesda, Md., USA

    Arthur S. Levine

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© 1989 Kluwer Academic Publishers, Dordrecht

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Heber, D., Byerley, L.O. (1989). Effects of Localized and Disseminated Cancers on Metabolism and Nutrition in Man. In: Levine, A.S. (eds) Etiology of Cancer in Man. Cancer Growth and Progression, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2532-8_7

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  • DOI: https://doi.org/10.1007/978-94-009-2532-8_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7644-9

  • Online ISBN: 978-94-009-2532-8

  • eBook Packages: Springer Book Archive

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