Skip to main content

Aids Epidemic and Neoplasms

  • Chapter
Etiology of Cancer in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 6))

  • 57 Accesses

Abstract

The first cases of AIDS (Acquired Immune Deficiency Syndrome) were in male homosexuals in Los Angeles, New York City, and San Francisco in 1981. It is a new disease, and among the first 31 cases were 26 presenting with Kaposi’s sarcoma (KS), a previously rare disease except in Central Africa. In 1872 Moritz K.Kaposi described the multi-centric pericyte or endothelial cell derived neoplasm, primarily in elderly men of Mediterranean origin, especially in Eastern or Central Europe. The original European cases and those that have been continued to be observed in Central Africa as well as the sporadic, rare cases in other parts of the world, respond well to treatment and usually disease is limited to the legs. The KS of AIDS rapidly spreads to other organs and is only temporarily responsive to therapy and is more like the virulent KS in children and young adults of Central Africa, as opposed to the more indolent form in older individuals there and in Eastern Europe. An important question, raised at the New York Academy of Science (NYAS) conference on AIDS in New York, November 14–17, 1983 is whether this virulent cancer in younger individuals of Central Africa is the virulent form of KS we are seeing as AIDS.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abemayor E, Calcaterra TC: Kaposi’s sarcoma and community-acquired immune deficiency syndrome. Arch Otolaryngol 109:536, 1983

    PubMed  CAS  Google Scholar 

  2. Amblard P, et al.: Pemphigus vulgaris and Kaposi sarcoma. Report of a new case (author’s transí). Dermatologica 163:58, 1981

    Article  PubMed  CAS  Google Scholar 

  3. Ammann AJ, et al.: Acquired immune dysfunction in homosexual men: Immunologic profiles. Clin Immunol Immunopathol 27:315, 1983

    Article  PubMed  CAS  Google Scholar 

  4. Barr’e-Sinoussi F, et al.: Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868, 1983

    Article  Google Scholar 

  5. Ben-Chetrit E, et al.: The association between Kaposi’s sarcoma and dysgammaglobulinemia. Cancer 49:1649, 1982

    Article  PubMed  CAS  Google Scholar 

  6. Ben-Chetrit E, Ben-Amitai D, Levo Y: The association between Kaposi’s sarcoma and dysgammaglobulinemia. Cancer 49:1649, 1982

    Article  PubMed  CAS  Google Scholar 

  7. Boldogh I, et al.: Kaposi’s sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies. Int J Cancer 28:469, 1981

    Article  PubMed  CAS  Google Scholar 

  8. Brauer MK, Gates PE, Doyle JL: Visceral Kaposi’s sarcoma presenting with gingival lesions. Oral Surg 50:151, 1980

    Article  PubMed  CAS  Google Scholar 

  9. Cahill KM Ed: The AIDS epidemic. New York: St. Martin’s Press, 1983

    Google Scholar 

  10. Carbone A, Volpe R: Kaposi’s sarcoma in lymph nodes concurrent with Hodgkin’s disease. Am J Clin Pathol 80:228, 1983

    PubMed  CAS  Google Scholar 

  11. Cazzola M et al: Kaposi’s sarcoma complicating immunosuppressive therapy for angioimmunoblastic lymphadenopathy with dysproteinemia. Tumor 68:537, 1982

    CAS  Google Scholar 

  12. Cerimene D: Kaposi’s Sarcoma. S&P Medical and Scientific Books, New York, 1985

    Google Scholar 

  13. Chaganti RS, et al.: Specific translocations characterize Burkitt’s-like lymphoma of homosexual men with the acquired immunodeficiency syndrome. Blood 61:1265, 1983

    PubMed  CAS  Google Scholar 

  14. Coscia GC, et al.: Multiple myeloma associated with Kaposi’s sarcoma: a case report. Arch Intern Med 143:1243, 1983

    Article  Google Scholar 

  15. Echard M, et al.: Association of Kaposi’s sarcoma with acute myeloblastic leukemia. Apropos of a case. Proc Natl Acad Sci USA 80:4861, 1983

    Article  Google Scholar 

  16. Enlow RW, et al.: Increased frequency of HLA-DR5 in lym-phadenopathy stage of AIDS (letter). Lancet 2:51, 1983

    Article  PubMed  CAS  Google Scholar 

  17. Essex M, et al.: Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science 220:859, 1983

    Article  PubMed  CAS  Google Scholar 

  18. Gallo RC, et al: Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865, 1983

    Article  PubMed  CAS  Google Scholar 

  19. Gandner MG, Marx PA, Osborne KG, Lerche NW, Maul DH, et al.: Simian acquired immune deficiency syndrome (Abstract). Intern Conf on RHA Tumor Viruses, Denver, CO, June 11–14, 1984

    Google Scholar 

  20. Gelmann EP, et al.: Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS. Science 220:862, 1983

    Article  PubMed  CAS  Google Scholar 

  21. Giraldo G, Beth E, Kyalwazi SK: Etiological implications on Kaposi’s sarcoma. Antibiot Chemother 29:12, 1981

    PubMed  CAS  Google Scholar 

  22. Giraldo G, Beth E, Huang ES: Kaposi’s sarcoma and its relationship to cytomegalovirus (CMNV). III. CMV DNA and CMV early antigens in Kaposi’s sarcoma. Int J Cancer 26:23, 1980

    Article  PubMed  CAS  Google Scholar 

  23. Gottlieb MS, et al.: The acquired immunodeficiency syndrome. Ann Intern Med 99:208, 1983

    PubMed  CAS  Google Scholar 

  24. Gottlieb MS, et al.: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immuno-deficiency. New Eng J Med 305:425, 1981

    Article  Google Scholar 

  25. Guarda LA, et al: Lymphadenopathy in homosexual men. Morbid anatomy with clinical and immunologic correlations. Am J Clin Pathol 79:559, 1983

    PubMed  CAS  Google Scholar 

  26. Headley JL, Cole GW: The development of pseudo-Kaposi’s sarcoma after placement of a vascular access graft. Br J Dermatol 102:327, 1980

    Article  PubMed  CAS  Google Scholar 

  27. Hoshaw RA, Schwartz RA: Kaposi’s sarcoma after immunosuppressive therapy with prednisone. Arch Dermatol 116:1280, 1980

    Article  PubMed  CAS  Google Scholar 

  28. Hymes KB: Kaposi’s sarcoma in homosexual men — a report of eight cases. Lancet 2:598, 1981

    Article  PubMed  CAS  Google Scholar 

  29. Hie B, Brenner S, Lipitz R, Krakowski A: Kaposi’s sarcoma after steroid therapy for pemphigus foliaceus. Cancer 49:850, 1982

    Article  Google Scholar 

  30. Iversen OH, et al.: Kaposi’s sarcoma in a renal allograft recipient under long-term immunosuppressive therapy. Scand J Urol Nephrol 14:125, 1980

    Article  PubMed  CAS  Google Scholar 

  31. Kalinske M, Leone CR Jr: Kaposi’s sarcoma involving eyelid and conjunctiva. Ann Ophthalmol 14:497, 1982

    PubMed  CAS  Google Scholar 

  32. Kanki PJ, Alroy J, Essex M: Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from Wild-Caught African Green Monkeys. Science 230:951, 1985

    Article  PubMed  CAS  Google Scholar 

  33. Kessler E, Beer R: Multicentric giant lymph node hyperplasia clinically simulating angioimmunoblastic lymphadenopathy. Associated Kaposi’s sarcoma in two of three cases. Isr J Med Sci 19:230, 1983

    PubMed  CAS  Google Scholar 

  34. Klein E, et al.: Treatment of Kaposi’s sarcoma with vinblastine. Cancer 45:427, 1980

    Article  PubMed  CAS  Google Scholar 

  35. Konrads A, et al.: Kaposi’s sarcoma (Author’s transi). Dtsch Med Wochenschr 105:727, 1980

    Article  PubMed  CAS  Google Scholar 

  36. Kornfeld H, Axelrod JL: Pulmonary presentation of Kaposi’s sarcoma in a homosexual patient. Am Rev Respir Dis 127:248, 1983

    PubMed  CAS  Google Scholar 

  37. Kyalwazi SK: Kaposi’s sarcoma: Clinical features, experience in Uganda. Antibiot Chemother 29:59, 1981

    PubMed  CAS  Google Scholar 

  38. Leibowitz MR, et al.: Rapidly fatal lymphagioma-like Kaposi’s sarcoma. Histopathology 4:559, 1980

    Article  PubMed  CAS  Google Scholar 

  39. Leung F, Fam, AG, Osoba D: Kaposi’s sarcoma complicating corticosteroid therapy for temporal arteritis. Am J Med 71:320, 1981

    Article  PubMed  CAS  Google Scholar 

  40. Levy JA, Ziegler JL: Acquired immunodeficiency syndrome is an opportunistic infection and Kaposi’s sarcoma results from secondary immune stimulation. Lancet 2:78, 1983

    Article  PubMed  CAS  Google Scholar 

  41. Lo TC, et al.: Radiotherapy for Kaposi’s sarcoma. Cancer 45:684, 1980

    Article  PubMed  CAS  Google Scholar 

  42. Le Roux FB, Burman ND, Becker WB: Kaposi’s sarcoma in a renal allograft recipient with cytomegalovirus infection. A case report. S Afr Med J 62:252, 1982

    PubMed  Google Scholar 

  43. Marx JL: A virus by any other name. Science 227:1449, 1985

    Article  PubMed  CAS  Google Scholar 

  44. Masur H, et al.: An outbreak of community-acquired pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Eng J Med 305:1431, 1981

    Article  CAS  Google Scholar 

  45. McNutt NS, Fletcher V, Conant MA: Early lesions of Kaposi’s sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin. Am J Pathol 111:62, 1983

    PubMed  CAS  Google Scholar 

  46. Meynadier J, et al.: Kaposi’s sarcoma during local and general steroid therapy for psoriasis (author’s transí). Dermatologica 162:417, 1981

    Article  PubMed  CAS  Google Scholar 

  47. Modlin RL, et al.: Kaposi’s sarcoma in homosexual men: an immunohistochemical study. J Am Acad Dermatol 8:620, 1983

    Article  PubMed  CAS  Google Scholar 

  48. Moskowitz LB, et al.: Unusual causes of death in Haitians residing in Miami. High prevalence of opportunistic infections. JAMA 250:1187, 1983

    Article  PubMed  CAS  Google Scholar 

  49. Myskowski PL, Romano JF, Safai B: Kaposi’s sarcoma in young homosexual men. Cutis 29:31, 1982

    PubMed  CAS  Google Scholar 

  50. Nisce LZ, Safai B, Poussin-Rosillo H: Once weekly total and subtotal skin electron beam therapy for Kaposi’s sarcoma. Cancer 47:640, 1981

    Article  PubMed  CAS  Google Scholar 

  51. Osborn KG, Prahalada S, Lowenstein LJ, Gardner MTS, Maul DH, Hendrickson RV: The pathology of an epizootic of acquired immunodeficiency in Rhesus Macaques. Am J Path 114:94, 1984

    PubMed  CAS  Google Scholar 

  52. Pitchenik AE, et al.: Opportunistic infections and Kaposi’s sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med 98:277, 1983

    PubMed  CAS  Google Scholar 

  53. Poiesz B, et al.: Detection of human T-cell lymphoma/leukemia virus (HTLV) in patients with acquired immunodeficiency (AIDS) or generalized lymphoadenopathy syndrome (GLS). Acquired Immunodeficiency, Abstract, U. of Syracuse, et al. Blood 62:115a, 1983

    Google Scholar 

  54. Ramsey R, et al.: Isolation of human T-cell leukemia virus from circulating lymphocytes of two hemophiliacs with AIDS. Acquired Immunodeficiency, Abstract, Center for Disease Control, Atlanta and U. of Calgary, Alberta, Canada. Blood 62:116a, 1983

    Google Scholar 

  55. Rose HS, et al.: Alimentary tract involvement in Kaposi’s sarcoma: radiographic and endoscopic findings in 25 homosexual men. AJR 139:661, 1982

    PubMed  CAS  Google Scholar 

  56. Rutsaert J, et al.: Infectious pulmonary and neurologic complications of Kaposi’s sarcoma. Anatomo-clinical correlation with an ultrastructural study. Ann Anat Pathol 25:125, 1980

    CAS  Google Scholar 

  57. Safai B: Kaposi’s sarcoma. In: The AIDS Epidemic, Cahill KM (ed). New York: St. Martin’s Press, p 98. Chapter 8, 1983

    Google Scholar 

  58. Salikoff IJ (ed): Acquired immune deficiency syndrome. New York Academy of Science, Vol 427, 1984

    Google Scholar 

  59. Scalise G, et al.: Immune response in the course of Kaposi’s sarcoma. Boll Inst Sieroter Milan 59:632, 1980

    CAS  Google Scholar 

  60. Schroff RW, et al.: Immunological studies of homosexual men with immuno-deficiency and Kaposi’s sarcoma. Clin Immunol Immunopathol 3:300, 1983

    Article  Google Scholar 

  61. Schwartz RA, et al.: Cutaneous angiosarcoma resembling anaplastic Kaposi’s sarcoma in a homosexual man. Cancer 51:721, 1983

    Article  PubMed  CAS  Google Scholar 

  62. Solan AJ, Greenwald ES, Silvay O: Long-term complete remissions of Kaposi’s sarcoma with vinblastine therapy. Cancer 41:631, 1981

    Google Scholar 

  63. Sonnabend J, Witkin SS, Purtilo DT: Acquired immunodeficiency syndrome opportunistic infections, and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis. JAMA 249:2370, 1983

    Article  PubMed  CAS  Google Scholar 

  64. Synder RA, Schwartz RA: Telangiectactic Kaposi’s sarcoma. Occurrence in a patient with thymoma and myasthenia gravis receiving long-term immunosuppressive therapy. Arch Dermatol 118:1020, 1982

    Article  Google Scholar 

  65. Ulbright TM, Santa Cruz DJ: Kaposi’s sarcoma: relationship with hematologic, lymphoid, and thymic neoplasia. Cancer 47:963, 1981

    Article  PubMed  CAS  Google Scholar 

  66. Weprin L, et al.: Kaposi’s sarcoma: endoscopic observations of gastric and colon involvement. J Clin Gastroenterol 4:357, 1982

    Article  PubMed  CAS  Google Scholar 

  67. Wong RC, et al.: Pigmented purpuric lichenoid dermatitis of Gougerot-Blum mimicking Kaposi’s sarcoma. Cutis 47:169, 1983

    Google Scholar 

Updated reference

  • Booth W: A rebel without a cause of AIDS. Science 239(4847): 1465–8, 1988

    Article  Google Scholar 

  • Bratzke B, Stadler R, Eichhorn R, et al.: Disseminated mucocutaneous Kaposi sarcoma in AIDS. Clinical and therapeutic experiences in 13 patients. Hautarzt 38(5):286–94, 1987

    PubMed  CAS  Google Scholar 

  • Burke DS, Brundage JF, Redfield RR, et al.: Measurement of the false positive rate in a screening program for human immunodeficiency virus infections. New Engl J Med 319(15):961–4, 1988

    Article  PubMed  CAS  Google Scholar 

  • Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, et al.: Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol 7(4):294–9, 1987

    Article  PubMed  CAS  Google Scholar 

  • Diederich N, Karenberg A, Peters UH: Psychopathologic pictures in HIV infection: AIDS lethargy and AIDS dementia. Fortschr Neurol Psychiatr 56(6): 173–85, 1988

    Article  PubMed  CAS  Google Scholar 

  • Duesberg P: HIV is not the cause of AIDS. Science 241(4865):514, 517, 1988

    Article  PubMed  CAS  Google Scholar 

  • Levy JA (ed): AIDS — Pathogenesis and Treatment, New York, Marcel Dekker, 1988

    Google Scholar 

  • Quinn TC, Riggin CH, Kline RL, et al.: Rapid latex agglutination assay using recombinant envelope polypeptide for the detection of antibody to the HIV. JAMA 260(4):510–3, 1988

    Article  PubMed  CAS  Google Scholar 

  • Stramer SL, Heller JS, Coomes RW, et al.: Transmission of HIV by blood transfusion. New Engl J Med 319(8):513–14, 1988 (letter)

    Article  Google Scholar 

  • Ward JW, Holmberg, SD, Allen JR, et al.: Transmission of human immunodeficiency virus (HIV) by blood transfusions screened as negative for HIV antibody. New Engl J Med 318(8):473–78, 1988

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Dordrecht

About this chapter

Cite this chapter

Dawson, R.B. (1989). Aids Epidemic and Neoplasms. In: Levine, A.S. (eds) Etiology of Cancer in Man. Cancer Growth and Progression, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2532-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-2532-8_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7644-9

  • Online ISBN: 978-94-009-2532-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics