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Chemotherapy-Induced Neoplasms, Side Effects, and Drug Carcinogenicity

  • Chapter
Etiology of Cancer in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 6))

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Abstract

Most neoplasms, especially if untreated, are fatal diseases. Iatrogenic, including chemotherapy-induced neoplasms, belong to the approximately 80% of human neoplasms with partial environmental involvement (27). Naturally occurring second cancers must be separated from those which are iatrogenic (29). Due to host involvement, patients with one malignancy may be more prone to present later on with a second one (36). The primary method of treatment is by surgical removal of the primary tumor, resulting in a loss of metastatic inhibition which had been caused by the primary tumor (Chapter 10, Volume VIII). Surgery is generally followed by chemo- or radiotherapy. The combination of treatments has provided marked increase in patients’ survival, when the primary tumor has been of certain types, i.e. those found in young people, such as nephroblastoma or certain leukemias. The treatment with alkylating agents of multiple myeloma and breast and ovarian cancers probably contributes to the development of acute nonlymphocytic leukemia. New light on the tumor, host interactions may be shed by the studies of multiple cancer syndromes (5).

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Authors
  1. H. E. Kaiser
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Editors and Affiliations

  1. National Institutes of Child Health & Human Development, National Institutes of Health, Bethesda, Md., USA

    Arthur S. Levine

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© 1989 Kluwer Academic Publishers, Dordrecht

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Kaiser, H.E. (1989). Chemotherapy-Induced Neoplasms, Side Effects, and Drug Carcinogenicity. In: Levine, A.S. (eds) Etiology of Cancer in Man. Cancer Growth and Progression, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2532-8_15

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  • DOI: https://doi.org/10.1007/978-94-009-2532-8_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7644-9

  • Online ISBN: 978-94-009-2532-8

  • eBook Packages: Springer Book Archive

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