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Vaccines for the treatment and prevention of Helicobacter pylori infection

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Helicobacter pylori

Abstract

An immunological approach or a vaccine approach to clear chronic Helicobacter pylori infection was initially rejected by many investigators and clinicians, based on the observation that natural immunity was unable to cure or prevent Helicobacter infection and chronic atrophic gastritis. Recent animal studies, however, have established that immunization with Helicobacter whole cell extracts or purified components is efficient for the prevention of infection, and more importantly for the treatment of pre-existing infections. Therefore there is now considerable interest in the design of Helicobacter vaccines, which represent a promising alternative to conventional therapies, in which bad compliance and antibiotic resistance represent serious drawbacks1.

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Authors
  1. I. Corthésy-Theulaz
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  2. A. L. Blum
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  3. J.-P. Kraehenbuhl
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Corthésy-Theulaz, I., Blum, A.L., Kraehenbuhl, JP. (1996). Vaccines for the treatment and prevention of Helicobacter pylori infection. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_18

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

  • eBook Packages: Springer Book Archive

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