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Effects of abnormalities of gastrin and somatostatin in Helicobacter pylori infection on acid secretion

  • Chapter
Helicobacter pylori

Abstract

Before the discovery of H. pylori the aetiology of gastroduodenal diseases was largely viewed in terms of associated abnormalities of gastric secretion. Elevated acid secretion in patients with duodenal ulcers (DU) seemed likely to be damaging the duodenum, and diminished acid secretion in patients with gastric cancer allowed overgrowth of mitogen-producing bacteria. Consequently gastric cancer and DU rarely occurred in the same patient. Since it emerged that H. pylori plays a major role in these diseases, we and others have investigated the effect of this infection on gastric physiology. Initial work examined how H. pylori might elevate acid secretion in DU disease. As the link between H. pylori and gastric cancer emerged the acid-lowering effects of this infection became more interesting. One part of the work has explored patterns of acid secretion under specific conditions in the different patient groups. Other studies have used in-vitro systems to explore the cellular events which might underlie what is found in patients. We are learning how infection and inflammation affect endocrine and exocrine systems of the gastrointestinal tract. Knowledge remains rudimentary, and whilst we learn more about the effects of relevant factors on various cells it will become necessary to dissect which of these effects actually determine disease outcomes. Hopefully, knowledge of why H. pylori exerts opposite effects on acid in different individuals will help us to identify patients at particular risk of DU or cancer.

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References

  1. Carlborg L, Dahlgren S, Nordgren B. Gastric secretion of hydrochloric acid and sialic acid in patients with peptic ulcer and gastric cancer during intravenous infusion of histamine. Scand J Gastroenterol. 1970;5:427–31.

    PubMed  CAS  Google Scholar 

  2. Blair AJ, Feldman M, Barnett C, Walsh JH, Richardson CT. Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest. 1987;79:582–7.

    Article  PubMed  Google Scholar 

  3. Cox AJJ. Stomach size and its relation to chronic peptic ulcer. Arch Pathol. 1952;54:407–12.

    CAS  Google Scholar 

  4. Walsh JH, Richardson CT, Fordtran JS. pH dependence of acid secretion and gastrin release in normal and ulcer subjects. J Clin Invest. 1975;55:462–8.

    Article  PubMed  CAS  Google Scholar 

  5. Malagelada JR, Longstreth GF, Deering TB, Summerskill WH, Go VL. Gastric secretion and emptying after ordinary meals in duodenal ulcer. Gastroenterology. 1977;73:989–94.

    PubMed  CAS  Google Scholar 

  6. Hirschowitz BI, Tim LO, Helman CA, Molina E. Bombesin and G-17 dose responses in duodenal ulcer and controls. Dig Dis Sci. 1985;30:1092–103.

    Article  PubMed  CAS  Google Scholar 

  7. Helman CA, Hirschowitz BI. Divergent effects of bombesin and bethanechol on stimulated gastric secretion in duodenal ulcer and in normal men. Gastroenterology. 1987;92:1926–33.

    PubMed  CAS  Google Scholar 

  8. Schubert ML, Jong MJ, Makhlouf GM. Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus. Am J Physiol. 1991;261:G885–9.

    PubMed  CAS  Google Scholar 

  9. Achord JL. Gastric pepsin and acid secretion in patients with acute and healed duodenal ulcer. Gastroenterology. 1981;81:15–18.

    PubMed  CAS  Google Scholar 

  10. Taylor IL, Dockray GJ, Calam J, Walker RJ. Big and little gastrin responses to food in normal and ulcer subjects. Gut. 1979;20:957–62.

    Article  PubMed  CAS  Google Scholar 

  11. Moss S, Calam J. Helicobacter pylori and peptic ulcers: the present position. Gut. 1992;33: 289–92.

    Article  PubMed  CAS  Google Scholar 

  12. McHenry L Jr, Vuyyuru L, Schubert ML. Helicobacter pylori and duodenal ulcer disease: the somatostatin link? Gastroenterology. 1993;104:1573–5.

    PubMed  Google Scholar 

  13. Man WK, Thompson JN, Baron JH, Spencer J. Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer. Gut. 1986;27:418–22.

    Article  PubMed  CAS  Google Scholar 

  14. Walsh JH. Gastrin. In: Walsh JH, Dockray GJ, editors. Gut peptides: biochemistry and physiology. New York: Raven Press; 1994:75–121.

    Google Scholar 

  15. Calam J, Dockray GJ, Walker RJ, Owens D. Molecular forms of gastrin in peptic ulcer: a comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects. Eur J Clin Invest. 1980;10:241–7.

    Article  PubMed  CAS  Google Scholar 

  16. Eysselein VE, Maxwell V, Reedy T, Wunsch E, Walsh JH. Similar acid stimulatory potencies of synthetic human big and little gastrins in man. J Clin Invest. 1984;73:1284–90.

    Article  PubMed  CAS  Google Scholar 

  17. Kopin AS, Lee YM, McBride EW et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA. 1992;89:3605–9.

    Article  PubMed  CAS  Google Scholar 

  18. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32:698–701.

    Article  PubMed  CAS  Google Scholar 

  19. Ascencio F, Fransson LA, Wadstrom T. Affinity of the gastric pathogen Helicobacter pylori for the N-sulphated glycosaminoglycan heparan sulphate. J Med Microbiol. 1993;38:240–4.

    Article  PubMed  CAS  Google Scholar 

  20. Lehy T. Trophic effect of some regulatory peptides on gastric exocrine and endocrine cells of the rat. Scand J Gastroenterol. 1994;19(Suppl. 101):27–30.

    Google Scholar 

  21. Odera G, Holton J, Altare F, Vaira D, Ainley C, Ansaldi N. Amoxycillin plus tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen 1 and gastrin level. Lancet. 1989;1:690–2.

    Article  Google Scholar 

  22. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet. 1989;1:1167–8.

    Article  PubMed  CAS  Google Scholar 

  23. Beardshall K, Moss S, Gill J et al. Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. Gut. 1992;33:601–3.

    Article  PubMed  CAS  Google Scholar 

  24. Graham DY, Opekun A, Lew GM, Klein PD, Walsh JH. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology. 1991; 100:1571–5.

    PubMed  CAS  Google Scholar 

  25. Mulholland G, Ardill JE, Fillmore D, Chittajallu RS, Fullarton GM, McColl KE. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut. 1993;34: 757–61.

    Article  PubMed  CAS  Google Scholar 

  26. Konturek JW, Gillessen A, Konturek SJ, Domschke W. Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients. Gut. 1995;37:482–7.

    Article  PubMed  CAS  Google Scholar 

  27. Buchan AM, Meloche RM, Kwok YN, Kofod H. Effect of cholecystokinin and secretin on somatostatin release from cultured antral cells. Gastroenterology. 1993; 104:1414–19.

    PubMed  CAS  Google Scholar 

  28. Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF. Effect of vagus, gastric inhibitory polypeptide, and HCl on gastrin and somatostatin release from perfused pig antrum. Am J Physiol. 1983;244:G515–22.

    PubMed  CAS  Google Scholar 

  29. Brand SJ, Stone D. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. J Clin Invest. 1988;82:1059–66.

    Article  PubMed  CAS  Google Scholar 

  30. el Nujumi AM, Dorrian CA, Chittajallu RS, Neithercut WD, McColl KE. Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. Gut. 1991;32:866–70.

    Article  PubMed  Google Scholar 

  31. Fahrenkrug J, Schaffalitzky de Muckadell OB, Hornum I, Rehfeld JF. The mechanism of hyper-gastrinemia in achlorhydria. Effect of food, acid, and calcitonin on serum gastrin concentrations and component pattern in pernicious anemia, with correlation to endogenous secretin concentrations in plasma. Gastroenterology. 1976;71:33–7.

    PubMed  CAS  Google Scholar 

  32. Lichtenberger LM, Dial EJ, Romero JJ, Lechago J, Jarboe LA, Wolfe MM. Role of luminal ammonia in the development of gastropathy and hypergastrinemia in the rat. Gastroenterology. 1995;108:320–9.

    Article  PubMed  CAS  Google Scholar 

  33. Saita H, Murakami M, Dekigai H, Kita T. Effects of ammonia and monochloramine on gastrin release and acid secretion. Gastroenterology. 1993; 104:A183.

    Google Scholar 

  34. Suzuki M, Miura S, Suematsu M et al. Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am J Physiol. 1992;263:G719–25.

    PubMed  CAS  Google Scholar 

  35. Blaser MJ. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992;102:720–7.

    PubMed  CAS  Google Scholar 

  36. Lehmann FS, Golodner EH, Wang J et al. Mononuclear cells and cytokines stimulate gastrin release from canine antral cells in primary culture. Am J Physiol. 1996 (in press).

    Google Scholar 

  37. Beales ILP, Calam J. Helicobacter pylori infection and exogenous tumour necrosis factor alpha produce similar effects on gastrin release from human antral fragments. Gut. 1996;38(Suppl. 1):A12.

    Google Scholar 

  38. Weigert N, Schaffer K, Schusdziarra V, Classen M, Schepp W. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Gastroenterology. 1996; 110:147–54.

    Article  PubMed  CAS  Google Scholar 

  39. Beales I, Srinivasan S, Blaser M et al. Effect of Helicobacter pylori constituents and inflammatory cytokines on gastrin release from isolated canine G-cells. Gastroenterology. 1995; 108:A779.

    Google Scholar 

  40. Chiba T, Yamada T. Gut somatostatin. In: Walsh JH, Dockray GJ, editors. Gut peptides: biochemistry and physiology. New York: Raven Press; 1994:123–45.

    Google Scholar 

  41. Bruns C, Weckbecker G, Raulf F, Lubbert H, Hoyer D. Characterization of somatostatin receptor subtypes. Ciba Found Symp. 1995;190:89–101.

    PubMed  CAS  Google Scholar 

  42. Lloyd KC, Wang J, Aurang K, Gronhed P, Coy DH, Walsh JH. Activation of somatostatin receptor subtype 2 inhibits acid secretion in rats. Am J Physiol. 1995;268:G102–6.

    PubMed  CAS  Google Scholar 

  43. Schubert ML, Edwards NF, Makhlouf GM. Regulation of gastric somatostatin secretion in the mouse by luminal acidity: a local feedback mechanism. Gastroenterology. 1988;94:317–22.

    PubMed  CAS  Google Scholar 

  44. Chayvialle JA, Miyata M, Rayford PL, Thompson JC. Effects of test meal, intragastric nutrients, and intraduodenal bile on plasma concentrations of immunoreactive somatostatin and vasoactive intestinal peptide in dogs. Gastroenterology. 1980;79:844–52.

    PubMed  CAS  Google Scholar 

  45. Inui T, Kinoshita Y, Yamaguchi A, Yamatani T, Chiba T. Linkage between capsaicin-stimulated calcitonin gene-related peptide and somatostatin release in rat stomach. Am J Physiol. 1991;261: G770–4.

    PubMed  CAS  Google Scholar 

  46. Wu V, Sumii K, Tari A, Sumii M, Walsh JH. Regulation of rat antral gastrin and somatostatin gene expression during starvation and after refeeding. Gastroenterology. 1991; 101:1552–8.

    PubMed  CAS  Google Scholar 

  47. Kaneko H, Nakada K, Mitsuma T et al. Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach. Dig Dis Sci. 1992;37:409–16.

    Article  PubMed  CAS  Google Scholar 

  48. Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992;340:930–2.

    Article  PubMed  CAS  Google Scholar 

  49. Odum L, Petersen HD, Andersen IB, Hansen BF, Rehfeld JF. Gastrin and somatostatin in Helicobacter pylori infected antral mucosa. Gut. 1994;35:615–18.

    Article  PubMed  CAS  Google Scholar 

  50. Gotz JM, Veenendaal RA, Biemond I, Muller ES, Veselic M, Lamers CB. Serum gastrin and mucosal somatostatin in Helicobacter pylori-associated gastritis. Scand J Gastroenterol. 1995; 30:1064–8.

    Article  PubMed  CAS  Google Scholar 

  51. Haruma K, Sumii K, Okamoto S et al. Helicobacter pylori infection is associated with low antral somatostatin content in young adults. Implications for the pathogenesis of hypergastrinemia. Scand J Gastroenterol. 1995;30:550–3.

    Article  PubMed  CAS  Google Scholar 

  52. Queiroz DM, Moura SB, Mendes EN, Rocha GA, Barbosa AJ, de Carvalho AS. Effect of Helicobacter pylori eradication on G-cell and D-cell density in children. Lancet. 1994;343: 1191–3.

    Article  PubMed  CAS  Google Scholar 

  53. Graham DY, Lew GM, Lechago J. Antral G-cell and D-cell numbers in Helicobacter pylori infection: effect of H. pylori eradication. Gastroenterology. 1993;104:1655–60.

    PubMed  CAS  Google Scholar 

  54. Gibbons AH, Legon S, Calam J. Effect of gastrin releasing peptide (GRP) infusions on the mRNAs encoding gastrin and somatostatin in patients with and without H. pylori infection. Gastroenterology. 1995; 108:A100.

    Article  Google Scholar 

  55. Park J, Chiba T, Yokotani K, DelValle J, Yamada T. Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin. Am J Physiol. 1989;257:G235–41.

    PubMed  CAS  Google Scholar 

  56. Sipponen P. Natural history of gastritis and its relationship to peptic ulcer disease. Digestion. 1992;51(Suppl. 1):70–5.

    Article  PubMed  Google Scholar 

  57. Beales ILP, Post L, Srinivasan S, Calam J, Yamada T, Del Valle J. Tumour necrosis factor-alpha (TNFa) decreases somatostatin release and somatostatin content of cultured canine D-cells. Gut. 1995;37(Suppl. 1):A84.

    Google Scholar 

  58. Vuyyuru L, Schubert ML, Harrington L, Arimura A, Makhlouf GM. Dual inhibitory pathways link antral somatostatin and histamin secretion in human, dog, and rat stomach. Gastroenterology. 1995;109:1566–74.

    Article  PubMed  CAS  Google Scholar 

  59. Queiroz DM, Mendes EN, Rocha GA et al. Histamine concentration of gastric mucosa in Helicobacter pylori positive and negative children. Gut. 1991;32:464–6.

    Article  PubMed  CAS  Google Scholar 

  60. Courillon-Mallet A, Launay JM et al. Helicobacter pylori infection: Physiopathologic implication of N alpha-methyl histamine. Gastroenterology. 1995;108:959–66.

    Article  PubMed  CAS  Google Scholar 

  61. Prinz C, Neumayer N, Classen M, Schepp W. Functional impairment of isolated rat entero-chromaffin-like cells by interleukin-1 beta. Gastroenterology. 1996;110:A234.

    Google Scholar 

  62. Bado A, Hervatin F, Lewin MJ. Pharmacological evidence for histamine H3 receptor in the control of gastric acid secretion in cats. Am J Physiol. 1991;260:G631–5.

    PubMed  CAS  Google Scholar 

  63. Bado A, Moizo L, Laigneau JP, Lewin MJ. Pharmacological characterization of histamine H3 receptors in isolated rabbit gastric glands. Am J Physiol. 1992;262:G56–61.

    PubMed  CAS  Google Scholar 

  64. Prinz C, Kajimura M, Scott DR, Mercier F, Heiander HF, Sachs G. Histamine secretion from rat enterochromaffin-like cells. Gastroenterology. 1993; 105:449–61.

    PubMed  CAS  Google Scholar 

  65. Preiss DU, Code CF. Effect of the H2-receptor antagonists (burimamide and metiamide) on gastric secretion stimulated by histamine and its methyl derivatives. J Pharmacol Exp Ther. 1975; 193:614–20.

    PubMed  CAS  Google Scholar 

  66. Huang LL, Cave DR, Gilbert JV, Wright A. Cloning and sequencing of the gene encoding an acid-inhibitory protein in Helicobacter pylori. Gastroenterology. 1996; 110:A927.

    Google Scholar 

  67. Beil W, Birkholz C, Wagner S, Sewing KF. Interaction of Helicobacter pylori and its fatty acids with parietal cells and gastric H+/K+ ATPase. Gut. 1994;35:1176–80.

    Article  PubMed  CAS  Google Scholar 

  68. Beales ILP, Calam J. Interleukin-1 beta and tumor necrosis factor-alpha inhibit aminopyrine accumulation in cultured rabbit parietal cells by multiple pathways. Gastroenterology. 1996;110:A62.

    Google Scholar 

  69. Beales ILP, Calam J. Effect of N-alpha methylhistamine on acid secretion in cultured rabbit parietal cells: implications for hypergastrinaemia and acid secretion. Gut. 1996;38(Suppl. 1):A37.

    Google Scholar 

  70. Kuipers EJ, Uyterlinde AM, Pena AS et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet. 1995;345:1525–8.

    Article  PubMed  CAS  Google Scholar 

  71. Graham DY, Alpert LC, Smith JL, Yoshimura HH. Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol. 1988;83:974–80.

    PubMed  CAS  Google Scholar 

  72. Kovaks TOG, Sytnik B, Calam J, Walsh JH. Helicobacter pylori infection impairs pH inhibition in non-duodenal ulcer subjects. Gastroenterology. 1993;104:A123.

    Google Scholar 

  73. Katelaris PH, Seow F, Lin BP, Napoli J, Ngu MC, Jones DB. Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut. 1993;34:1032–7.

    Article  PubMed  CAS  Google Scholar 

  74. Rademaker JW, Hunt RH. Helicobacter pylori and gastric acid secretion: the ulcer link? Scand J Gastroenterol Suppl. 1991;187:71–7.

    Article  PubMed  CAS  Google Scholar 

  75. Haruma K, Kawaguchi H, Yoshihara M et al. Relationship between Helicobacter pylori infection and gastric acid secretion in young healthy subjects. J Clin Gastroenterol. 1994;19:20–2.

    Article  PubMed  CAS  Google Scholar 

  76. Chandrakumaran K, Vaira D, Hobsley M. Duodenal ulcer, Helicobacter pylori, and gastric secretion [see comments]. Gut. 1994;35:1033–6.

    Article  PubMed  CAS  Google Scholar 

  77. Finlayson NDC, Girdwood RH, Samson RR, Shearman DJC. Gastric secretion, gastric antibody status and pernicious anaemia in carcinoma of the stomach. Digestion. 1969;2:338–46.

    Article  PubMed  CAS  Google Scholar 

  78. El-Omar E, Oien H, Wirz A, McColl KEL. Divergent effects of H. pylori on acid secretion. Gastroenterology. 1996;110:A102.

    Article  Google Scholar 

  79. Moss SF, Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori. Gut. 1993;34:888–92.

    Article  PubMed  CAS  Google Scholar 

  80. Chittajallu RS, Howie CA, McColl KE. Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects. Scand J Gastroenterol. 1992;27:857–62.

    Article  PubMed  CAS  Google Scholar 

  81. Jacobson K, Chiba N, James C, Armstrong D, Barrientos M, Hunt RH. Protracted gastric acid secretion in H. pylori positive DU patients following eradication. Gastroenterology. 1995; 108:A122.

    Google Scholar 

  82. Harris AW, Gummett PA, Misiewicz JJ, Baron JH. The effect of eradication of Helicobacter pylori on gastric acid output in patients with duodenal ulcers. Gastroenterology. 1995; 108:A109.

    Article  Google Scholar 

  83. Fontham ET, Ruiz B, Perez A, Hunter F, Correa P. Determinants of Helicobacter pylori infection and chronic gastritis. Am J Gastroenterol. 1995;90:1094–101.

    PubMed  CAS  Google Scholar 

  84. Correa P. Is gastric carcinoma an infectious disease? [editorial; comment]. N Engl J Med. 1991;325:1170–1.

    Article  PubMed  CAS  Google Scholar 

  85. Beales ILP, Davey N, Scunes D, Pusey C, Lechler R, Calam J. HLA Class II type and H. pylori-induced gastric atrophy. Gut. 1994;35(Suppl. 5):S45.

    Google Scholar 

  86. Bechi P, Romagnoli P, Panula P et al. Enterochromaffin-like cells and the ‘gastrin link’ between Helicobacter pylori and duodenal ulcer. Gastroenterology. 1996; 110:A62.

    Google Scholar 

  87. Moss SF, Calam J. Acid secretion and sensitivity to gastrin in duodenal ulcer patients: effect of eradication of H. pylori. Gut. 1993;34:888–92.

    Article  PubMed  CAS  Google Scholar 

  88. el Omar E, Penman I, Dorrian CA, Ardill JE, McColl KE. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut. 1993;34:1060–5.

    Article  PubMed  Google Scholar 

  89. Verhulst ML, Hopman WP, Tangerman A, Jansen JB. Eradication of Helicobacter pylori infection in patients with non-ulcer dyspepsia. Effects on basal and bombesin-stimulated serum gastrin and gastric acid secretion. Scand J Gastroenterol. 1995;30:968–73.

    Article  PubMed  CAS  Google Scholar 

  90. Hamlet A, Dalenback L, Fandriks L, Olbe L. Helicobacter pylori infection interferes with the regulation of gastrin release and acid secretion. Acta Gastro-Enterol Belg. 1993;56(Suppl. 111).

    Google Scholar 

  91. El-Omar E, Penman I, Dorrian CA, Ardill JES, McColl KEL. Eradicating Helicobacter pylori infection lowers gastrin-mediated acid secretion by two-thirds in duodenal ulcer patients. Gut. 1993;34:1060–5.

    Article  PubMed  CAS  Google Scholar 

  92. Bojko JB, Burage M, Erdag S et al. Novel GRP/CCK test exqluates D-G interaction and parietal cell secretion in H.P.-positive duodenal ulcer patients. Gastroenterology. 1996; 110:A67.

    Google Scholar 

  93. Hamlet A, Olbe L. Gastric emptying, duodenal acid load and duodenal bulb acidity in Helicobacter pylori-infected subjects. Am J Gastroenterol. 1994;89:1325.

    Google Scholar 

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Authors
  1. J. Calam
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  2. I. L. P. Beales
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  3. A. Gibbons
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  4. M. Ghatei
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  5. J. Del Valle
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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Calam, J., Beales, I.L.P., Gibbons, A., Ghatei, M., Del Valle, J. (1996). Effects of abnormalities of gastrin and somatostatin in Helicobacter pylori infection on acid secretion. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_11

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_11

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