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Cyclosporin A and tolerance induction in experimental animals

  • Chapter
Cyclosporin

Abstract

Since the discovery of the immunosuppressive properties of cyclosporin A (CsA) in 19721, and its introduction into transplantation research in 19772,3, there have been numerous publications reporting the successful induction, by CsA, of ‘tolerance’ to a wide range of organ allografts in a broad spectrum of animal models. Heterotopic heart grafts between fully incompatible inbred strains of rats were the first organ allografts to be used as a model for tolerance induction with CsA2. This model has been tested and confirmed by others using different strain combinations4–6. Tolerance has also been reported to kidney7, liver8, bowel9, and composite tissue (limb) grafts10 in rats, kidney grafts in rabbits11, dogs12 and rhesus monkeys13, and heart grafts in pigs14. In contrast to organ grafts, skin graft survival is dependent on the continued presence of CsA. Significant prolongations have been achieved in mice15,16, rats17,18, rabbits19 and dogs20,21. However, skin graft rejection following withdrawal of CsA treatment is the rule.

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  1. Susan M. L. Lim
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Editors and Affiliations

  1. Immunopathology Laboratory, Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB9 2ZD, Scotland

    Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (Reader in Immunology) (Reader in Immunology)

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© 1989 Kluwer Academic Publishers

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Lim, S.M.L., White, D.J.G. (1989). Cyclosporin A and tolerance induction in experimental animals. In: Thomson, A.W. (eds) Cyclosporin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0859-8_5

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  • DOI: https://doi.org/10.1007/978-94-009-0859-8_5

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