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The vegetative nervous system and atrial natriuretic factor

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Atherosclerosis and Cardiovascular Disease

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Abstract

The vegetative nervous system (VNS) and atrial natriuretic factor (ANF) are linked in various ways: 1) the VNS affects ANF release; 2) ANF changes some VNS activities and 3) the VNS influences the effects of ANF. These functional relationships have been confirmed by literature reports. Our studies on the effects of Dopamine infusion on ANF and noradrenaline (NA) plasma levels in healthy subjects and in congestive heart failure patients suggested that NA may be involved in ANF release. In diseases characterized by an increase in sympathetic tone we found that hypersympathicotonia does not appear to modify plasma ANF levels if central venous pressure (CVP) is normal as in hypovolemic shock due to melena. On the other hand, in patients with acute myocardial infarction (AMI) during bradycardia and hypotension syndrome characterized by an increase in parasympathetic tone we observed normal ANF and CVP values; this suggests that hypervagotonia curbs peptide secretion because ANF release is usually high during AMI.

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Authors and Affiliations

  1. Institute of Medical Pathology, Bologna University, Policlinico S. Orsola, via Massarenti 9, Bologna, 40138, Italy

    F. Fontana & P. Bernardi

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  1. F. Fontana
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  2. P. Bernardi
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Editors and Affiliations

  1. Clinica Medica Generale e Terapia Medica I, Policlinico S. Orsola, via Massarenti, 9, Bologna, 40138, Italy

    Giancarlo Descovich , Antonio Gaddi , Gianluigi Magri  & Sergio Lenzi , ,  & 

  2. Department of Gerontology and Atherosclerosis Centre, University of Bologna, via Massarenti 9, Bologna, 40138, Italy

    Giancarlo Descovich  & Antonio Gaddi  & 

  3. Department of Geriatrics and Lipid Clinic, University of Bologna, Bologna, 40138, Italy

    Gianluigi Magri

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© 1990 Kluwer Academic Publishers

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Fontana, F., Bernardi, P. (1990). The vegetative nervous system and atrial natriuretic factor. In: Descovich, G., Gaddi, A., Magri, G., Lenzi, S. (eds) Atherosclerosis and Cardiovascular Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0731-7_13

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  • DOI: https://doi.org/10.1007/978-94-009-0731-7_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6814-7

  • Online ISBN: 978-94-009-0731-7

  • eBook Packages: Springer Book Archive

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