Skip to main content
SpringerLink
Log in

Selection and Management of the Donor

  • Chapter
The Transplantation and Replacement of Thoracic Organs

Abstract

The importance of a well-functioning donor heart cannot be overemphasized; it is clearly crucial to the success of the heart transplant procedure, particularly if orthotopic transplantation is to be performed. Early donor heart failure accounts for approximately 25% of the deaths of heart transplant patients today (Chapter 31), and is therefore an area where significant improvements can still be made. Careful selection and meticulous management of a potential donor therefore remain essential.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cooper, D.K.C. (1989). A clinical survey of cardiac transplantation between ABO-blood group incompatible recipient and donors. J. Heart Transplant. In press

    Google Scholar 

  2. Nakatani, T., Aida, H., Macris, M.P. and Frazier, O.H. (1988). Effect of ABO blood type on survival of CSA-treated cardiac transplant patients (abstract). J. Heart Transplant., 7, 81

    Google Scholar 

  3. Fentz, V. and Gormsen, J.(1962).Electrocardiographic patterns in patients with cerebrovascular accidents. Circulation, 25, 22

    PubMed  CAS  Google Scholar 

  4. Cooper, D.K.C.(1976).The donor heart; the present position with regard to resuscitation, storage, and assessment of viability. J.Surg. Res., 21, 363

    Article  PubMed  CAS  Google Scholar 

  5. L’Age-Stehr, J., Schwarz, A., Offermann, G., Langmaack, H., Bennhold, I., Niedrig, M. and Koch, M.A. (1985). HTLV-III infection in kidney transplant recipients. Lancet, 2, 1361

    Article  PubMed  Google Scholar 

  6. Prompt, C.A., Reis, M.M., Grillo, F.M., Kopstein, J., Kraemer, B., Manfro, R.C., Maia, M.H. and Comiran, J.B. (1985). Transmission of AIDS virus at renal transplantation. Lancet, 2, 672

    Article  PubMed  CAS  Google Scholar 

  7. Schwarz, A., Hoffman, F., L’Age-Stehr, J., Tegzess, A.M. and Offermann, G. (1987). Human immunodeficiency virus transmission by organ donation. Transplantation, 44, 21

    Article  PubMed  CAS  Google Scholar 

  8. Rubin, R.H., Jenkins, R.L., Shaw, B.W, Shaffer, D., Pearl, R.H., Erb, S., Monaco, A.P. and Van Thiel, D.H. (1987). The acquired immunodeficiency syndrome and transplantation. Transplantation, 44, 1

    Article  PubMed  CAS  Google Scholar 

  9. Burch, G.E., Meyer, R. and Abildskov, J. (1954). A new electrocardiographic pattern observed in cerebrovascular accidents. Circulation, 9, 719

    PubMed  CAS  Google Scholar 

  10. De Pasquale, N.P. and Burch, C.E. (1969). How normal is the donor heart? Am. Heart J., 77, 719

    Article  Google Scholar 

  11. Greenhoot, A.H. and Reichenbach, D.D. (1969). Cardiac injury and subarachnoid hemorrhage. J. Neurosurg., 30, 521

    Article  PubMed  CAS  Google Scholar 

  12. Heggtveit, H.A. (1970). The donor heart; brain death and pathological changes in the heart. Laval Med., 41, 178

    PubMed  CAS  Google Scholar 

  13. Smith, R.P. and Tomlinson, B.E. (1954). Subendocardial hemorrhages associated with intracranial lesions. J. Pathol. Bacteriol., 68j, 327

    Article  Google Scholar 

  14. Griepp, R.B., Stinson, E.B., Clark, D.A., Dong, E.Jr. and Shumway, N.E. (1971). The cardiac donor. Surg. Gynecol. Obstet., 133, 792

    PubMed  CAS  Google Scholar 

  15. Novitzky, D, Wicomb, W.N, Cooper, D.K.C, Rose, A.G, Fraser, R.C. and Barnard, C.N. (1984). Electrocardiographic, hemodynamic and endocrine changes occurring during experimental brain death in the Chacma baboon. J. Heart Transplant., 4, 63

    Google Scholar 

  16. Wicomb, W.N, Cooper, D.K.C, Lanza, R.P, Novitzky, D. and Isaacs, S. (1986). The effects of brain death and 24 hours storage by hypothermic perfusion on donor heart function in the pig. J. Thorac. Cardiovasc. Surg., 91, 896

    PubMed  CAS  Google Scholar 

  17. Novitzky, D, Wicomb, W.N, Cooper, D.K.C, Rose, A.G. and Reichart, B. (1986). Prevention of myocardial injury during brain death by total cardiac sympathectomy in the Chacma baboon. Ann. Thorac. Surg., 41, 520

    Article  PubMed  CAS  Google Scholar 

  18. Novitzky, D., Wicomb, W.N., Rose, A G., Cooper, D.K.C. and Reichart, B. (1987). Pathophysiology of pulmonary edema following experimental brain death in the Chacma baboon. Ann. Thorac. Surg., 43, 288

    Article  PubMed  CAS  Google Scholar 

  19. Novitzky, D., Cooper, D.K.C., Rose, A.G., Wicomb, W.N., Becerra, E. and Reichart, B. (1987). Early donor heart failure following transplantation — the possible role of myocardial injury sustained during brain death. Clin. Transplantation, 1, 108

    Google Scholar 

  20. Novitzky, D., Cooper, D.K.C., Rose, A.G. and Reichart, B. (1987). Prevention of myocardial injury by pre-treatment with verapamil hydrochloride following experimental brain death; efficacy in a baboon model. Am. J. Emerg. Med., 15, 11

    Article  Google Scholar 

  21. Novitzky, D., Cooper, D.K.C., Morrell, D. and Isaacs, S. (1988). Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine (T3) therapy. Transplantation, 45, 32

    Article  PubMed  CAS  Google Scholar 

  22. Novitzky, D., Rose, A.G. and Cooper, D.K.C. (1988). Injury of myocardial conduction tissue and coronary artery smooth muscle following brain death in the baboon. Transplantation, 45, 964

    Article  PubMed  CAS  Google Scholar 

  23. Novitzky, D., Cooper, D.K.C. and Reichart, B. (1987). Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation, 43, 852

    PubMed  CAS  Google Scholar 

  24. Novitzky, D., Wicomb, W.N., Cooper, D.K.C. and Tjaalgard, M.A. (1987). Improved cardiac function following hormonal therapy in brain-dead pigs: relevance to organ donation. Cryobiology, 24, 1

    Article  PubMed  CAS  Google Scholar 

  25. Wicomb, W.N, Cooper, D.K.C. and Novitzky, D. (1986). Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy. Transplantation, 41, 29

    Article  PubMed  CAS  Google Scholar 

  26. Toledo-Pereyra, L.H. and Jara, F.M. (1979). Myocardial protection with methylprednisolone. J. Thorac. Cardiovasc. Surg., 77, 619

    PubMed  CAS  Google Scholar 

  27. Cooper, D.K.C, Novitzky, D. and Zuhdi, N. (eds.) Hormonal therapy — a new concept in the management of organ donors. Transplant. Proc., 20, 1

    Google Scholar 

Download references

Authors
  1. D. K. C. Cooper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Novitzky
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Cooper, D.K.C., Novitzky, D. (1990). Selection and Management of the Donor. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0711-9_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation