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Assessment of Myocardial Perfusion by PET

  • Chapter
Clinical PET

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 28))

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Abstract

Several tracer approaches have been proposed for the assessment of myocardial perfusion with positron emission tomography (PET) in the clinical setting. These include nitrogen-13 (13N) labelled ammonia, oxygen-15 (15O) labelled water, rubidium-82 (82Rb) and potassium-38 (38K). These tracers require a local cyclotron for production, except for 82Rb which may be delivered directly to the patient from an on-site generator. There are two specific clinical applications of PET that have been proposed for the evaluation of patients with coronary artery disease (CAD) [1-3]. The first is the noninvasive detection of CAD and estimation of the severity of the disease. This is performed using a PET perfusion agent at rest and during pharmacologic vasodilation. A unique application of PET is the noninvasive calculation of absolute regional myocardial perfusion at rest and during vasodilation in humans using [15O]water or [13N]ammonia. However, most centers rely on the qualitative interpretation of 82Rb or [13N]ammonia images for the detection of CAD and the assessment of its severity. The second clinical application of PET is the assessment of myocardial viability in CAD patients with left ventricular dysfunction. The most common approach is to determine whether metabolic activity assessed by 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is preserved in regions with reduced perfusion, thus indicating tissue viability.

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Authors
  1. Jacques A. Melin
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  2. Jean-Louis Vanoverschelde
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  3. Bernhard Gerber
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  4. Christian Michel
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  5. William Wijns
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  6. Anne Bol
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Eberhard-Karls-University, Roentgenweg 13, D-72076, Tuebingen, Germany

    Roland B. Bares

  2. INB-CNR, Department of Nuclear Medicine, University of Milan, Scientific Institute H.S., Via Olgettina 60, Raffaele, Milan, I- 20132, Italy

    Giovanni Lucignani

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© 1996 Kluwer Academic Publishers

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Melin, J.A., Vanoverschelde, JL., Gerber, B., Michel, C., Wijns, W., Bol, A. (1996). Assessment of Myocardial Perfusion by PET. In: Bares, R.B., Lucignani, G. (eds) Clinical PET. Developments in Nuclear Medicine, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0309-8_2

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  • DOI: https://doi.org/10.1007/978-94-009-0309-8_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6624-2

  • Online ISBN: 978-94-009-0309-8

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