Skip to main content

Part of the book series: NATO ASI Series ((NSSE,volume 305))

  • 349 Accesses

Abstract

Multivariable control of both pH and ammonium levels in an aerobic continuous yeast culture was demonstrated. A buffered glucose feed was used for pH control. This control loop was coupled with ammonium control using an on-line ammonia electrode suspended above a pH-adjusted sample stream from the fermentor. The dilution rate of the culture was the sum of the two individual feed rates. The advantages and implications of multivariable feedback control in continuous fermentation are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agrawal, Pramod, Lim, Henry C. (1984) ‘Analyses of Various Control Schemes for Continuous Bioreactors’ Advances In Biochemical Engineering/Biotechnology, 30, 61–90.

    Article  CAS  Google Scholar 

  • Bungay, H.R. (1972), ‘Continuous Culture With Proportional Control Of Substrate Concentration’, Proc. IV IFS Ferment. Technol. Today, 117-120.

    Google Scholar 

  • Fiechter, A. (1984), ‘Physical and Chemical Parameters of Microbial Growth’, Advances in Biochemical Engineering/Biotechnology, 30, 7–60.

    Article  CAS  Google Scholar 

  • Kleman, Gary L., Chalmers, Jeffrey J., Luli, Gregory W. and Strohl, William R. (1991), ‘Glucose-Stat, a Glucose-Controlled Continuous Culture’, Applied Environ. Micro., 57, 918–923

    CAS  Google Scholar 

  • Martin, G.A., and Hempfling, W.P. (1976), ‘Method for the regulation of microbial population density during continuous culture at high growth rates’, Arch. Microbiol., 107, 41–47.

    Article  CAS  Google Scholar 

  • Meschke, J., Bennemann, H., Herbst, H, Dormeier, S. and Hempel, D.C. (1988) ‘On-Line HPLC-Measurement and Control of Substrate in a Continuously Operated Biological Tank Reactor’, Bioprocess Engineering 3, 151–157.

    Article  CAS  Google Scholar 

  • Rutgers, Michiel, Balk, Peter A. and van Dam, Karel (1990) ‘Quantification of Multiple- Substrate Controlled Growth-Simultaneous Ammonium and Glucose Limitation in Chemo- stat Cultures of Klebsiella Pneumoniae’, Arch Microbiol 153, 478–484.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Gostomski, P.A., Clesceri, L.S., Bungay, H.R. (1996). Multivariable Control of a Continuous Culture. In: Moreira, A.R., Wallace, K.K. (eds) Computer and Information Science Applications in Bioprocess Engineering. NATO ASI Series, vol 305. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0177-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0177-3_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6564-1

  • Online ISBN: 978-94-009-0177-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics