Abstract
Scale-up has been one of the major problems in bioprocess technology. Earlier methods of trial-and-error have now been replaced by those which involve the understanding of the fundamental phenomena, at least for the simpler cases. For more complicated heterogeneous systems the employment of various rules of thumb is still widely practised. A summary of various strategies for bioreactor scale-up is given below.
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References
Becker, H. A. (1976) Dimensionless Parameters: Theory and Methodology, Applied Science Publishers, London.
Bird, R. B., Stewart, W. E. and Lightfoot, E. N. (1960) Transport Phenomena, Wiley, New York.
Brown, D. E. (1982) ‘Industrial scale operations of microbial processes’, J. Chem. Technol. Biotechnol., 32, 34–46.
Harnby, N., Edwards, M.F. and Nienow, A.W. (eds.) (1985) Mixing in the Process Industries, Butterworth, London.
Ho, C.S. and Oldshue, J.Y. (eds.) (1987) Biotechnology Processes: Scale-up and Mixing, AIChE, New York.
Johnstone, R. E. and Thring, M. W. (1957) Pilot Plants, Models and Scale-up Methods in Chemical Engineering, McGraw-Hill, New York.
Khang, S. J. and Levenspiel, O. (1976) ‘New scale-up and design method for stirrer agitated batch mixing vessels’, Chem. Engng. Sci., 31 (7), 569–577.
Kossen, N. W. F. and Oosterhuis, N. M. G. (1985) ‘Modelling and scaling-up of bioreactors’, in H.-J. Rehm and G. Reed (eds.), Biotechnology, Vol. 2, H. Brauer (Vol. ed.) Ch. 24, 572–605, VCH, Weinheim.
Laine, J. and Kuoppamaki, R. (1979) ‘Development of the design of large scale fermenters’, Ind. Engng. Chem. Process Des. Dev., 18, 501–506.
Levenspiel, O. (1972) Chemical Reaction Engineering, Wiley, New York.
Mann, R. (1983) Gas-liquid Contacting in Mixing Vessels, IChemE, Rugby.
Norwood, K.W. and Metzner, A. B. (1960) ’Flow patterns and mixing rates in agitated vessels, A.I.Ch.E. J., 6, 432–437.
Ovaskainen, P., Lundell, R. and Laiho, P. (1976) ‘Engineering of fermentation plants. Part 2. Fermenter design and scale-up’, Process Biochem., 11, 37–55.
Penney, W.R. (1971) Chem. Engr., 787, 86.
Reuss, M., Bajpai, R. K., Lenz, R., Niebelschutz, H. and Papalexiou, A. (1980) ‘Scale- up strastegies based on the interaction of transport and reaction’VIth Int. Ferment. Symp., July 20-25, London, Ontario, Canada, F-7.2.1.
Shaftlein, R.W. and Russel, T.W.F. (1968) ‘Two-phase reactor design, tank-type reactors’, Ind. Engng. Chem., 60, 12–27.
Sweere, A. P. J., Luyben, K. Ch. A. M. and Kossen, N. W. R (1987) Regime analysis and scale-down: tools to investigate the performance of bioreactors, Enzyme Microb. Technol, 9 (July), 386–392.
Tatterson, G. B. (1971) ‘Scale-up procedures and power consumption in agitated vessels’, Food Technol., May, 65–70.
Uhl, V. W. and von Essen, J. A. (1986) in Mixing: Theory and Practice, V.W. Uhl and J.B. Gray (eds.), Vol. III, Ch. 15, Academic Press, New York.
Wang, D. I. C. and Fewkes, R.C. J. (1977) ‘Effect of operating variables and geometric parameters on the behavior of non-Newtonian, mycelial antibiotic fermentations’, Dev. Ind. Microbiol., 18, 39–56.
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© 1996 Kluwer Academic Publishers
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Mavituna, F. (1996). Strategies for Bioreactor Scale-Up. In: Moreira, A.R., Wallace, K.K. (eds) Computer and Information Science Applications in Bioprocess Engineering. NATO ASI Series, vol 305. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0177-3_11
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DOI: https://doi.org/10.1007/978-94-009-0177-3_11
Publisher Name: Springer, Dordrecht
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