Abstract
The frequency of malignant diseases in adult patients on dialysis figures at about 4% and rises to about 6% after renal transplantation (RTPL) [1–3]. Especially the incidence of lymphomas is augmented: 4 times higher on dialysis and 37 times higher after transplantation as compared to age-matched controls. The risk of patients starting renal replacement therapy (RRT) in childhood to develop a de novo malignancy is less well defined, because the observation period under pediatric care is short as compared to their whole lifetime. While the expected incidence of malignant diseases between the age of 5 and 25 years is 1/10 000 in the normal population, some short-term studies report a frequency of 0.7% of malignancies in children on dialysis and 1–4 % after transplantation [4–8]. Among the malignancies in children after transplantation lymphomas were the predominant tumors and comprised 49% of all malignancies in comparison to 11% of tumors in the general pediatric population [4, 7]. To evaluate the frequency of malignancies among patients starting RRT during childhood a retrospective analysis was done with the cooperation of all German pediatric nephrology centers.
For the Arbeitsgemeinschaft Pädiatrische Nephrologie.
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© 1996 Kluwer Academic Publishers
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Wingen, AM. (1996). German multicenter analysis of malignancies following renal replacement therapy in children. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_3
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DOI: https://doi.org/10.1007/978-94-009-0175-9_3
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