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Adverse Intrauterine Environment and Gamete/Embryo-Fetal Origins of Diseases

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Gamete and Embryo-fetal Origins of Adult Diseases

Abstract

The ‘fetal origins of adult disease (FOAD)’ hypothesis proposes that developmental programming during gestation may influence adult health and disease [1]. It suggests a process where events occurring at critical, or sensitive, periods of fetal development, permanently alter structure, physiology, or metabolism. These changes predispose affected individuals to diseases in later life.

Barker and his colleagues were the first to develop the concept of FOAD based on significant associations between low birthweight and the risk of chronic diseases in adulthood, including coronary artery disease, hypertension and stroke, type 2 diabetes, and osteoporosis. Several other groups confirmed associations between birthweight and adult health in other populations. These adverse intrauterine environments include gestational diabetes mellitus (GDM), intrauterine undernutrition and pre-eclampsia, which are common and severe gestational complications. Furthermore, certain antenatal nutritional disturbances can increase the risk of diseases later in life without affecting fetal growth. In this chapter, we will discuss the evidence related to adverse intrauterine environment and embryo-fetal origins of diseases.

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Authors and Affiliations

  1. The Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, People’s Republic of China

    Min-Yue Dong, Fang-Fang Wang, Jie-Xue Pan & He-Feng Huang

  2. Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

    Min-Yue Dong, Fang-Fang Wang, Jie-Xue Pan & He-Feng Huang

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  1. The Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, Zhejiang, People's Republic of China

    He-Feng Huang

  2. The Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, Zhejiang, People's Republic of China

    Jian-Zhong Sheng

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Dong, MY., Wang, FF., Pan, JX., Huang, HF. (2014). Adverse Intrauterine Environment and Gamete/Embryo-Fetal Origins of Diseases. In: Huang, HF., Sheng, JZ. (eds) Gamete and Embryo-fetal Origins of Adult Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7772-9_3

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