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Homeostasis

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Homeostasis - Tumor - Metastasis

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Abstract

Homeostasis refers to the constancy of the inner environment that secures the stability of equilibrium processes of the organism. It is also related to the relative stability of the chemical and physical environment of cells and organisms. The chemical requirements of maintaining the external requirements of homeostasis are represented by water, food, oxygen, while the physical conditions include temperature and atmospheric pressure. The organism is in homeostatic equilibrium when its cells do not suffer in any kind of shortage and can exert their activities without limitation. The dynamic equilibrium of the body (see the scheme above) is maintained by the participation of all organs helping to secure the stability of the body liquids. Stress conditions, e.g. heat, pain, hypoxia may cause the instability of the inner environment and endanger the homeostasis of the organism. Self regulatory systems have been evolved and serve to weaken the oscillations of the internal changes. Due to this involuntary regulation the ideal value (“set point”) is approached and the stability of the inner environment restored. These regulatory systems act primarily by negative feedback mechanisms and with much lower frequency by positive feed-forward reactions.

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References

  • Alexander RM (1982) Optima for animals, Rev edn. Edward Arnold Publishers, London

    Google Scholar 

  • Alexander SP, Mathie A, Peters JA (2007) Catalytic receptors. Br J Pharmacol 150 Suppl 1(S1):S122–S127

    Google Scholar 

  • Altman PL, Dittmer DS (eds) (1972–1974) Biology data books, vols 1–3, vol 3, 2nd edn. Federation of American Societies for Experimental Biology, Bethesda, pp 1751–1805

    Google Scholar 

  • Ariëns EJ (1954) Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Arch Int Pharmacodyn Ther 99:32–49

    PubMed  Google Scholar 

  • Arnold L, Smith M (2006) Britain, Australia and the bomb. Palgrave MacMillan Press, Basingstoke, p 336

    Google Scholar 

  • Athans M, Falb PL (1966) Optimal control. McGraw Hill Book Company, New York

    Google Scholar 

  • Avogadro A (1811) Essai d’une manière de déterminer les masses relatives des molécules élémentaires des corps, et les proportions selon lesquelles elles entrent dans ces combinaisons. J Phys Chim d’Histoire Nat 73:55–76

    Google Scholar 

  • Banfalvi G (1991a) Evolution of osmolyte systems. Biochem Educ 19:136–139

    Google Scholar 

  • Banfalvi G (1991b) Conversion of oxidative energy to reductive power in the citrate cycle. Biochem Educ 19:24–26

    CAS  Google Scholar 

  • Banfalvi G (1992a) Conversion of oxidative energy to reductive power: II. Contribution of hydration to the reductive energy in the β-oxidation of fatty acids. Biochem Educ 22:105–106

    Google Scholar 

  • Banfalvi G (1992b) Conservation of oxidative energy to reductive power: III. Hydrolytic energy conservation in amino acid metabolism. Biochem Educ 20:216–218

    CAS  Google Scholar 

  • Banfalvi G (1994) The metabolic clockwork. Biochem Educ 22:137–139

    Google Scholar 

  • Banfalvi G (1999) Estimating the energy content of metabolites. Biochem Edu 27:79–82

    CAS  Google Scholar 

  • Banfalvi G (2009) Apoptotic chromatin changes. Springer, Dordrecht, pp 1–30

    Google Scholar 

  • Banfalvi G (2011) Heavy metals, trace elements and their cellular effects. In: Banfalvi G (ed) Cellular effects of heavy metals. Springer, Dordrecht, pp 6–7

    Google Scholar 

  • Banfalvi G, Mikhailova M, Poirier LA, Chou MW (1997) Multiple subphases of DNA replication in CHO cells. DNA Cell Biol 16:1493–1498

    PubMed  CAS  Google Scholar 

  • Banga JA (2005) Optimization in computational systems biology. BMC Syst Biol 2:247

    Google Scholar 

  • Becker RO (1972) Electrical stimulation of partial limb regeneration in mammals. Bull N Y Acad Med 48:627–641

    PubMed  CAS  Google Scholar 

  • Bell G (1982) The masterpiece of nature: the evolution and genetics of sexuality. University of California Press, Berkeley, p 378

    Google Scholar 

  • Ben-Shlomo I, You HS, Rauch R, Kowalski HW, Hsueh AJ (2003) Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci STKE 2003:re9

    PubMed  Google Scholar 

  • Bernard C (1878) Lecons sur les phénomènes de la vie communs aux animaux et aux végétaux. Billiėré, Paris

    Google Scholar 

  • Bernard C (1957) An introduction to the study of experimental medicine. Dover Publications, Inc, New York

    Google Scholar 

  • Breining G (2007) Super volcano. Voyageur Press, St. Paul

    Google Scholar 

  • Cameron JR, Skofronick JG, Grant RM (1999) Physics of the body, 2nd edn. Medical Physics Publishing, Madison, p 182

    Google Scholar 

  • Cannon WB (1926) Physiological regulation of normal states: some tentative postulates concerning biological homeostatics. In: Pettit A (ed) A Charles Richet: ses amis, ses collègues, ses élèves. Éditions Médicales, Paris, p 91

    Google Scholar 

  • Cannon WB (1939) The wisdom of the body, Rev edn. W. W. Norton, New York

    Google Scholar 

  • Cannon C (2004) Paying the price at the pump: dystonia from mutations in a Na+/K+-ATPase. Neuron 43:153–154

    PubMed  CAS  Google Scholar 

  • Carlson BM (2007) Principles of regenerative biology. Elsevier Inc, New York, 400

    Google Scholar 

  • Cascio M (2004) Structure and function of the glycine receptor and related nicotinicoid receptors. J Biol Chem 279:19383–19386

    PubMed  CAS  Google Scholar 

  • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil W, Jr JT, Roccella EJ (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206–1252

    PubMed  CAS  Google Scholar 

  • Choi YH, Kurtz A, Stamm C (2011) Mesenchymal stem cells for cardiac cell therapy. Hum Gene Ther 22:3–17

    PubMed  CAS  Google Scholar 

  • Congreve M, Marshall F (2010) The impact of GPCR structures on pharmacology and structure-based drug design. Br J Pharmacol 159:986–996

    PubMed  CAS  Google Scholar 

  • Convertino VA (1991) Blood volume: its adaptation to endurance training. Med Sci Sports Exerc 23:1338–1348

    PubMed  CAS  Google Scholar 

  • Dalton J (1808) A system or chemical philosophy. S. Russel, London

    Google Scholar 

  • Day TA (2005) Defining stress as a prelude to mapping its neurocircuitry: no help from allostasis. Prog Neuropsychopharmacol Biol Psychiatry 29:1195–1200

    PubMed  Google Scholar 

  • DeFronzo RA, Sherwin RS, Kraemer N (1987) Effect of physical training on insulin action in obesity. Diabetes 36:1379–1385

    PubMed  CAS  Google Scholar 

  • DeLaney RG, Lahiri S, Hamilton R, Fishman AP (1977) Acid-base balance and plasma composition in the aestivating lungfish (Protopterus). Am J Physiol 232:R10–R17

    PubMed  CAS  Google Scholar 

  • Doolittle WF (2000) Uprooting the tree of life. Sci Am 282:90–95

    PubMed  CAS  Google Scholar 

  • Dudek RW (1999) High-yield cell and molecular biology. Lippincott Williams and Wilkins, Philadelphia, p 19

    Google Scholar 

  • Duester G (2008) Retinoic acid synthesis and signaling during early organogenesis. Cell 134:921–931

    PubMed  CAS  Google Scholar 

  • Encyclopedia Britannica (1973) Blood. Encyclopedia Britannica, Chicago

    Google Scholar 

  • Epstein FH (1979) The shark rectal gland: a model for the active transport of chloride. Yale J Biol Med 52:517–523

    PubMed  CAS  Google Scholar 

  • Eriksson KF, Lindgarde F (1991) Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study. Diabetologia 34:891–898

    PubMed  CAS  Google Scholar 

  • Fausto N, Mead JE (1989) Regulation of liver growth: protooncogenes and transforming growth factors. Lab Invest 60:4–13

    PubMed  CAS  Google Scholar 

  • Foster JB (2009) The ecological revolution: making peace with the planet. Monthly Review Press, New York, p 73

    Google Scholar 

  • Gabor MH, Hotchkiss RD (1979) Parameters governing bacterial regeneration and genetic recombination after fusion of Bacillus subtilis protoplasts. J Bacteriol 137:1346–1353

    PubMed  CAS  Google Scholar 

  • Gay-Lussac JL (1809) Mémoires de la Société d’Arcueil 2, 207 [from Boorse HA, Motz L (eds) (1966) The world of the atom, vol 1. Basic Books, New York (translation: Alembic club reprint no. 4)]

    Google Scholar 

  • Gordon MS, Schmidt-Nielsen K, Kelly HM (1961) Osmotic regulation in the crab-eating frog (Rana cancrivora). J Exp Biol 38:659–678

    CAS  Google Scholar 

  • Gorter E, Grendel F (1925) On bimolecular layers of lipoids on the chromocytes of the blood. J Exp Med 41:439–443

    PubMed  CAS  Google Scholar 

  • Guyton AC (1971) Basic human physiology: normal function and mechanisms of disease. W.B. Sanders Company, Philadelphia

    Google Scholar 

  • Guyton AC (1991) Textbook of medical physiology, 8th edn. W.B. Saunders Company, Philadelphia, p 274

    Google Scholar 

  • Haldane JBS (1928) The origin of life. Ration Ann 148:3–10

    Google Scholar 

  • Hammond D, Wilby J (2006) The life and work of James Grier Miller. Syst Res Behav Sci 23:429–435

    Google Scholar 

  • Hansen JT, Koeppen BM (2002) Netter’s atlas of human physiology. Icon Learning Systems, Teterboro

    Google Scholar 

  • Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, Suncion VY, Tracy M, Ghersin E, Johnston PV, Brinker JA, Breton E, Davis-Sproul J, Schulman IH, Byrnes J, Mendizabal AM, Lowery MH, Rouy D, Altman P, Wong Po Foo C, Ruiz P, Amador A, Da Silva J, McNiece IK, Heldman AW (2012) Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA 308:2369–2379

    PubMed  CAS  Google Scholar 

  • Harms C, Ross T, Segars A (2002) Plasma biochemistry reference values of wild bonnethead sharks, Sphyrna tiburo. Vet Clin Pathol 31:1–5

    Google Scholar 

  • Heber-Katz E, Leferovich JM, Bedelbaeva K, Gourevitch D (2004) Spallanzani’s mouse: a model of restoration and regeneration. Curr Top Microbiol Immunol 280:165–189

    PubMed  CAS  Google Scholar 

  • Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147–152

    PubMed  CAS  Google Scholar 

  • Hendler RW (1971) Biological membrane ultrastructure. Physiol Rev 51:66–97

    PubMed  CAS  Google Scholar 

  • Hess GH (1840) Rescherches thermochimics. Bull Sci Acad Imp Sci 8:257–272

    Google Scholar 

  • Higgins GM, Anderson RM (1931) Experimental pathology of the liver of the white rat following partial surgical removal. Arch Pathol 12:186–202

    Google Scholar 

  • Himeno Y, Fukuda Y, Sakai Y, Kokuryu H, Hatanaka M, Kohigashi K, Imura H (1989) Expression of cellular oncogenes and their possible roles in liver regeneration. Acta Hepatol Jpn 30:656–661

    CAS  Google Scholar 

  • Himeno Y, Engelman RW, Good RA (1992) Influence of calorie restriction on oncogene expression and DNA synthesis during liver regeneration. Proc Natl Acad Sci USA 89:5497–5501

    PubMed  CAS  Google Scholar 

  • Hinkle PC, Kumar MA, Resetar A, Harris DL (1991) Mechanistic stoichiometry of mitochondrial oxidative phosphorylation. Biochemistry 30:3576–3582

    PubMed  CAS  Google Scholar 

  • Holmes FL (1980) Hans Krebs and the discovery of the ornithine cycle. Fed Proc 39:216–225

    PubMed  CAS  Google Scholar 

  • Horecker BL (1976) Unravelling the pentose phosphate pathway. In: Kornberg A, Cornudella I, Horecker BI, Oro J (eds) Reflections on biochemistry. Pergamon Press, New York, pp 65–72

    Google Scholar 

  • Horowitz NH (1945) On the evolution of biochemical syntheses. Proc Natl Acad Sci USA 31:153–157

    PubMed  CAS  Google Scholar 

  • Illingworth CM (1974) Trapped fingers and amputated fingertips in children. J Pediatr Surg 9:853–858

    PubMed  CAS  Google Scholar 

  • Johnson AK (2007) The sensory psychobiology of thirst and salt appetite. Med Sci Sports Exerc 39:1388–1400

    PubMed  Google Scholar 

  • Kay J, Weitzman PDJ (eds) (1987) Biochemical Society symposium 54. Cambridge University Press, Cambridge

    Google Scholar 

  • Kelsell DP, Dunlop J, Hodgins MB (2001) Human diseases: clues to cracking the connexin code? Trends Cell Biol 11:2–6

    PubMed  CAS  Google Scholar 

  • Kharash M (1929) Heats of combustion of organic compound. Bur Stand J Res 2:359–430

    Google Scholar 

  • Klok MD, Jakobsdottir S, Drent ML (2007) The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 8:21–34

    PubMed  CAS  Google Scholar 

  • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403

    PubMed  CAS  Google Scholar 

  • Krebs HA, Johnson WA (1937) The role of citric acid in intermediate metabolism in animal tissues. Enzymologia 4:148–156

    CAS  Google Scholar 

  • Kujala UM, Marti P, Kaprio J, Hernelahti M, Tikkanen H, Sarna S (2003) Occurrence of chronic disease in former top-level athletes. Predominance of benefits, risks or selection effects? Sports Med 33:553–561

    PubMed  Google Scholar 

  • Lee CP, Gu Q, Xiong Y, Mitchell RA, Ernster L (1996) P/O ratios reassessed: mitochondrial P/O ratios consistently exceed 1.5 with succinate and 2.5 with NAD-linked substrates. FASEB J 10:345–350

    PubMed  CAS  Google Scholar 

  • Lehninger AL (1975) Biochemistry, 2nd edn. Worth, New York, p 397

    Google Scholar 

  • Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo JE (2011) Harrison’s principles of internal medicine, 18th edn. McGraw-Hill, New York, p 142

    Google Scholar 

  • Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH (1992) A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 268:63–67

    PubMed  CAS  Google Scholar 

  • Marbán E, Malliaras K (2012) Mixed results for bone marrow–derived cell therapy for ischemic heart disease. JAMA 308:2405–2406

    PubMed  Google Scholar 

  • Marieb EN, Hoehn K (2007) Human anatomy and physiology, 7th edn. Pearson Benjamin Cummings, San Francisco

    Google Scholar 

  • Meister A, Anderson ME (1983) Glutatione. Ann Rev Biochem 52:711–760

    PubMed  CAS  Google Scholar 

  • Meléndez-Hevia E, Waddell TG, Shelton ED (1993) Optimization of molecular design in the evolution of metabolism: the glycogen molecule. Biochem J 295:477–483

    PubMed  Google Scholar 

  • Meuret AE, Rosenfield D, Hofmann SG, Suvak MK, Roth WT (2009) Changes in respiration mediate changes in fear of bodily sensations in panic disorder. J Psychiatr Res 43:634–641

    PubMed  Google Scholar 

  • Michal G (1999) Biochemical pathways: an atlas of biochemistry and molecular biology. Wiley, New York

    Google Scholar 

  • Michalopoulos GK (1990) Liver regeneration: molecular mechanisms of growth control. FASEB J 4:176–187

    PubMed  CAS  Google Scholar 

  • Michalopoulos GK, DeFrances MC (1997) Liver regeneration. Science 276:60–66

    PubMed  CAS  Google Scholar 

  • Nathan DG, Orkin SH (eds) (1998) Hematology of infancy and childhood, 5th edn. W.B. Saunders, Philadelphia

    Google Scholar 

  • Neglia JP, FitzSimmons SC, Maisonneuve P, Schöni MH, Schöni-Affolter F, Corey M, Lowenfels AB (1995) The risk of cancer among patients with cystic fibrosis. N Engl J Med 332:494–499

    PubMed  CAS  Google Scholar 

  • Negus SS (2006) Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists. Biochem Pharmacol 71:1663–1670

    PubMed  CAS  Google Scholar 

  • Noves R Jr, Woodman C, Bodkin JA, Yagla SJ (2004) Hypochondriacal concerns in panic disorder and major depressive disorder: a comparison. Int J Psychiatry Med 34:143–154

    Google Scholar 

  • Nowak MA, Sigmund K (2004) Evolutionary dynamics of biological games. Science 303:793–799

    PubMed  CAS  Google Scholar 

  • Oparin AI (1954) The origin of life, 3rd edn. Academic, New York

    Google Scholar 

  • Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20:537–544

    PubMed  CAS  Google Scholar 

  • Pitkänen E, Jouhten P, Rousu J (2009) Inferring branching pathways in genome-scale metabolic networks. BMC Syst Biol 3:103

    PubMed  Google Scholar 

  • Pollak M (2012) Energy balance and cancer risk at the cellular and whole organism level: modification by metformin. BMC Proc 6(Suppl 3):O21

    Google Scholar 

  • Pontryagin LS, Boltyanskii VG, Gamkrelidze RV, Mischenko EF (1962) The mathematical theory of optimal processes. Interscience Publishers, New York

    Google Scholar 

  • Pough FH (1979) Origin and radiation of amphibians in vertebrate life. Macmillan, New York, pp 291–322

    Google Scholar 

  • Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE (1990) Increased cell division as a cause of human cancer. Cancer Res 50:7415–7421

    PubMed  CAS  Google Scholar 

  • Rehak M, Csuka I, Szepessy E, Banfalvi G (2000) Subphases of DNA replication in Drosophila cells. DNA Cell Biol 19:607–612

    PubMed  CAS  Google Scholar 

  • Rose RA, Jiang H, Wang X, Helke S, Tsoporis JN, Gong N, Keatingm SC, Parker TG, Backx PH, Keating A (2008) Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 26:2884–2892

    PubMed  CAS  Google Scholar 

  • Saris WH (2001) The concept of energy homeostasis for optimal health during training. Can J Appl Physiol 26(Suppl):S167–S175

    PubMed  Google Scholar 

  • Sarna S, Sahi T, Koskenvuo M, Kapprio J (1993) Increased life expectancy of world class male athletes. Med Sci Sports Exerc 25:237–244

    PubMed  CAS  Google Scholar 

  • Savageau MA (1998) Demand theory of gene regulation. I. Quantitative development of the theory. Genetics 149:1665–1676

    PubMed  CAS  Google Scholar 

  • Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL (1996) Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575–1584

    PubMed  CAS  Google Scholar 

  • Shinar G, Dekel E, Tlusty T, Alon U (2006) Rules for biological regulation based on error minimization. Proc Natl Acad Sci USA 103:3999–4004

    PubMed  CAS  Google Scholar 

  • Singaravelu K, Padanilam BJ (2009) In vitro differentiation of MSC into cells with a renal tubular epithelial-like phenotype. Ren Fail 31:492–502

    PubMed  CAS  Google Scholar 

  • Singer SJ, Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175:720–731

    PubMed  CAS  Google Scholar 

  • Smith HW (1943) Lectures on the kidney. Porter Lectures IX. University of Kansas Press, Lawrence

    Google Scholar 

  • Smith HW (1953) From fish to philosopher. Little, Brown and Co, Boston

    Google Scholar 

  • Sousa M, Brás-Silva C, Leite-Moreira A (2009) The role of leptin in the regulation of energy balance. Acta Med Port 22:291–298

    PubMed  Google Scholar 

  • Starr C, Taggart R (1989) Biology. The unity and diversity of life, 5th edn. Wadsworth, Belmont

    Google Scholar 

  • Stephenson RP (1997) A modification of receptor theory. Br J Pharmacol 120(4 Suppl 4):106–120

    PubMed  CAS  Google Scholar 

  • Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J (eds) Handbook of life stress, cognition and health. Wiley, New York

    Google Scholar 

  • Sutherland WJ (2005) The best solution. Nature 435:569

    PubMed  CAS  Google Scholar 

  • Szepessy E, Nagy G, Jenei Z, Serfozo Z, Csuka I, James J, Banfalvi G (2003) Multiple subphases of DNA repair and poly(ADP-ribose) synthesis in Chinese hamster ovary (CHO-K1) cells. Eur J Cell Biol 82:201–207

    PubMed  CAS  Google Scholar 

  • ter Kuile BH, Cook M (1994) The kinetics of facilitated diffusion followed by enzymatic conversion of the substrate. Biochim Biophys Acta 1193:235–239

    PubMed  Google Scholar 

  • Thomas GR, Wen J (2006) Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Cancer Res 26:4093–4102

    CAS  Google Scholar 

  • Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350

    PubMed  CAS  Google Scholar 

  • Van Valen L (1973) A new evolutionary law. Evol Theory 1:1–30

    Google Scholar 

  • Vassalli G, Moccetti T (2011) Cardiac repair with allogeneic mesenchymal stem cells after myocardial infarction. Swiss Med Wkly 141:w13209

    PubMed  Google Scholar 

  • Weast RC, Astle MJ (eds) (1982–1983) Handbook of chemistry and physics. CRC Press, Boca Raton

    Google Scholar 

  • Weindruch R, Walford RL (1988) The retardation of aging and disease by dietary restriction . Thomas, Springfield

    Google Scholar 

  • Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Güldenagel M, Deutsch U, Söhl G (2002) Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 383:725–737

    PubMed  CAS  Google Scholar 

  • Williamson JR (1965) Glycolytic control mechanisms I: inhibition of glycolysis by acetate and pyruvate in the isolated, perfused rat heart. J Biol Chem 240:2308–2321

    PubMed  CAS  Google Scholar 

  • Wingfield JC (2003) Control of behavioural strategies for capricious environments. Anim Behav 66:807–816

    Google Scholar 

  • White TW, Paul DL (1999) Genetic diseases and gene knockouts reveal diverse connexin functions. Ann Rev Physiol 61:283–310

    CAS  Google Scholar 

  • Wood T (1985) The pentose phosphate pathway. Academic, Orlando

    Google Scholar 

  • World Health Organization (2009) Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization, Geneva

    Google Scholar 

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  1. Microbial Cell Biology and Cell Biology, University of Debrecen, Debrecen, Hungary

    Gaspar Banfalvi

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Banfalvi, G. (2014). Homeostasis. In: Homeostasis - Tumor - Metastasis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7335-6_1

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