Abstract
Glioblastomas are the most common primary tumor of the brain. These tumors are differentiated from other tumors because of their highly vascularized nature, making them a prime target for anti-angiogenic therapies. Multiple phase II trials have investigated the efficacy of bevacizumab (Avastin), an antibody targeting vascular endothelial growth factor (VEGF), on recurrent glioblastomas. The beneficial results of bevacizumab in these studies have led to randomized Phase III trials looking at the impact of using bevacizumab at the time of diagnosis by adding it to the standard Stupp protocol of radiation therapy plus 6 months of temozolomide. Due to the fact that there continues to be a fraction of patients who do not respond or have disease progression while on bevacizumab therapy as well as patients who experience side effects of bevacizumab requiring stoppage of treatment, future studies will be needed to determine, potentially by gene expression studies, the best candidates for this targeted therapy.
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Castro, B.A., Aghi, M.K. (2014). Impact of Bevacizumab Chemotherapy on Glioblastomas. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 11. Tumors of the Central Nervous System, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7037-9_8
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