Abstract
Acute lymphoblastic leukemia (ALL) is the major paediatric cancer in developed countries. It has long been speculated that common genetic variation influences the development of this haematological malignancy, however until recently evidence for this hypothesis has been lacking. The advent of genome-wide association studies (GWAS) has allowed the search for this class of susceptibility allele to be conducted on a genome-wide basis. Such analyses have identified novel disease genes for ALL and underscore the importance of polymorphic variation in B-cell development genes as determinants of leukemia risk. Furthermore these data indicate that a significant difference in the risk of an individual developing ALL can be attributed to heritable genetic factors.
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Sherborne, A.L., Houlston, R.S. (2013). Risk of Childhood Acute Lymphoblastic Leukemia: Identification of Inherited Susceptibility. In: Hayat, M. (eds) Pediatric Cancer, Volume 4. Pediatric Cancer, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6591-7_11
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