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Abstract

Hirudotherapy – the use of medicinal leeches for curative purposes – is one of the oldest practices in medicine, dating back to the Stone Age. Over the years, the use of leeches has evolved from a simple blood-letting procedure into a scientifically-based physiologic process with rational defined clinical applications. The Greek physician Nicander of Colophon is considered to have been the pioneer of hirudotherapy. While the Romans were the first to use the name Hirudo for leeches in the first century A.D., it was the Swedish physician and zoologist Linnaeus who used the term Hirudo medicinalis in 1754 to describe the application of leeches in medical treatment. During the Middle Ages, the golden era for blood-letting, leeches were used by almost all physicians to cure anything from headaches to hemorrhoids. In Russia, hirudotherapy reached its zenith in the late eighteenth and early nineteenth century when leech harvesting and leech therapy netted the country an annual six million silver rubles. By the end of the nineteenth century, with the advent of antibacterial therapy, leeches fell out of favor, and became associated with medicinal quackery in the majority of countries.

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References

  • Adams SL (1989) The emergency management of a medicinal leech bite. Ann Emerg Med 18:316–319

    Article  PubMed  CAS  Google Scholar 

  • Andereya S, Stanzel S, Mans U et al (2008) Assessment of leech therapy for knee osteoarthritis: a randomized study. Acta Orthop 79:235–243

    Article  PubMed  Google Scholar 

  • Bapat RD, Acharya BS, Juvekar S, Dahanukar SA (1998) Leech therapy for complicated varicose veins. Indian J Med Res 107:281–284

    PubMed  CAS  Google Scholar 

  • Baskova IP (1999) Hirudotherapy method in prophylaxis and treatment of cardiovascular diseases. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, pp 4–5

    Google Scholar 

  • Baskova YP, Nikonov GY (1987) Leeches prostaglandins and the enzyme destabilase as thrombotic agents of the preparation from the medicinal leeches. Thromb Haemost 58:70

    Google Scholar 

  • Baskova YP, Nikonov GY (1991) Destabilase, the novel isopeptidase with thrombolytic activity. Blood Coagul Fibrinolysis 2:167–172

    Article  PubMed  CAS  Google Scholar 

  • Baskova IP, Jusupova GI, Nikonov GI (1984) Lipase and choline-esterase activity of salivary secrete of Hirudo medicinalis. Biochimia 49:676–678

    CAS  Google Scholar 

  • Baskova IP, Nikonov GI, Mirkamalova EG et al (1988) The influence of the drug from medicinal leeches (Hirudo medicinalis) on phagocytosis and the complement system. Kaz Med J 69:334–336

    Google Scholar 

  • Baskova IP, Khalil S, Nartikova VF, Paskhina TS (1992) Inhibition of plasma kallikrein, kininase and kinin-like activities of preparation from the medicinal leech. Thromb Res 67:721–730

    Article  PubMed  CAS  Google Scholar 

  • Belezkaya GA (2007) Hirudotherapy in patients with early stages of primary open-angle glaucoma. Krasnoyarsk

    Google Scholar 

  • Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840

    PubMed  CAS  Google Scholar 

  • Bogdanova II, Demidova OO, Polikarpova EE (2003) Hirudo medicinalis in the treatment of painful muscle syndromes of osteochondrosis. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, pp 51–53

    Google Scholar 

  • Borovaya EP (2008) Leeches and endoecological rehabilitation in a complex sanatorium treatment of patients with coronary heart disease of middle and old age. Moscow

    Google Scholar 

  • Brody GA, Maloney WJ, Hentz VR (1989) Digit replantation applying the leech Hirudo medicinalis. Clin Orthop Relat Res 245:133–137

    PubMed  Google Scholar 

  • Bunker TD (1981) The contemporary use of the medicinal leech. Injury 12:430–432

    Article  PubMed  CAS  Google Scholar 

  • Chaban TN, Kapralova VV, Savinov VA (2003) Hirudotherapy in gynecology. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, p 68

    Google Scholar 

  • Chalisova NI, Pennijajnen VP, Baskova IP, Zavalova LL, Bazanova AV (2003) Neurite-stimulating activity of components of the salivary gland secretion of the medicinal leech in cultures of sensory neurons. Neurosci Behav Physiol 33:411–414

    Article  PubMed  CAS  Google Scholar 

  • Chemeris AV, Konirtaeva NN (1999) Hirudotherapy in Kazakhstan. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, pp 125–126

    Google Scholar 

  • Chepeha DB, Nussenbaum B, Bradford CR, Teknos TN (2002) Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer. Arch Otolaryngol Head Neck Surg 128:960–965

    PubMed  Google Scholar 

  • Chmeil H, Anadere I, Moser K (1989) Hemoreological changes under blood leeching. Clin Hemorheol 9:569–576

    Google Scholar 

  • de Chalain TM (1996) Exploring the use of the medicinal leech: a clinical risk-benefit analysis. J Reconstr Microsurg 12:165–172

    Article  PubMed  Google Scholar 

  • Derganc M, Zdravic F (1960) Venous congestion of flaps treated by application of leeches. Br J Plast Surg 13:187–192

    Article  PubMed  CAS  Google Scholar 

  • Durrant C, Townley WA, Ramkumar S, Khoo CT (2006) Forgotten digital tourniquet: salvage of an ischemic finger by application of medicinal leeches. Ann R Coll Surg Engl 88:462–464

    Article  PubMed  CAS  Google Scholar 

  • Dzekh SA (2000) The clinic, immunological disorders, hirudotherapy in patients with the Rossolimo-Melkerssona-Rosenthal syndrome. Moscow

    Google Scholar 

  • Eldor A, Orevi M, Rigbi M (1996) The role of the leech in medical therapeutics. Blood Rev 10:201–209

    Article  PubMed  CAS  Google Scholar 

  • Eldor A, Orevi M, Rigbi M (1998) Beneficial role of the leech in post-phlebitic syndrome. In: Book of abstracts of the 3rd international conference on biotherapy, Jerusalem, pp 12–13

    Google Scholar 

  • Elliot JM, Tullet PA (1984) The status of the medicinal leech Hirudo medicinalis in Europe and especially in the British Isles. Biol Conserv 29:15–26

    Article  Google Scholar 

  • Ena YM (2003) Hirudotherapy in complex treatment of patients with hypertension disease. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, pp 24–25

    Google Scholar 

  • Farber FM (1987) Pathogenic methods of treatment of peripheral palsy of facial nerve. Novosibirsk

    Google Scholar 

  • Fields WS (1991) The history of leeching and hirudin. Haemostasis 21:3–10

    PubMed  Google Scholar 

  • Fowler A (1999) The clinical application of leeches. In: Book of abstracts of the 4th international biotherapy conference “bridging the millenia”, Porthcawl, pp 9–10

    Google Scholar 

  • Fritz H, Oppitz KH, Gebhardt M, Oppitz I, Werle E, Marx R (1969) On the presence of a trypsin-plasmin inhibitor in hirudin. Hoppe Seylers Z Physiol Chem 350:91–92

    Article  PubMed  CAS  Google Scholar 

  • Frolov VA, Frolova EA (1999) Combined use of hirudotherapy and manual therapy in treatment of scapulohumeral periarthropaty. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, pp 26–27

    Google Scholar 

  • Gantimurova OG (2001) Leeches in the treatment and rehabilitation of patients with arterial hypertension. In: Practical and experimental hirudology: results in a decade (1991–2001). Book of abstracts of the 7th conference of hirudologists of Russia and CIS, Luberzi, pp 8–10

    Google Scholar 

  • Gilyova OS (2000) Hirudotherapy and the skin. In: Book of abstracts of the 5th international conference on biotherapy, Wurzburg, pp 9–10

    Google Scholar 

  • Gilyova OS (2003) Hirudotherapy in modern Russian medicine: clinical and experimental aspects. In: Book of abstracts of the 6th international conference on biotherapy, Sivas, pp 22–23

    Google Scholar 

  • Gilyova OS (2005) Modern hirudotherapy – a review. The BeTER LeTTER 2(1):1–3

    Google Scholar 

  • Gilyova OS, Gibadullina NV (2003) Hirudotherapy in treatment of periodontal diseases: clinical and functional indices. In: Book of abstracts of the 6th international conference on biotherapy, Sivas, pp 24–25

    Google Scholar 

  • Gilyova O, Rogozhnikov G, Barer G et al (1988) Hirudotherapy from the depth of centuries. West-Ural Branch of Russian Academy of Science Publishing House, Perm

    Google Scholar 

  • Gilyova OS, Korobeinikova GA, Gilyova ES et al (1999) The achievements of modern medicine in systemic hirudotherapy. Russ J Biomech 3:68–77

    Google Scholar 

  • Gilyova OS, Korobeinikova GA, Gibadullina NV (2000) Experimental studies on the healing and anti-inflammatory effects of leeching. In: Book of abstracts of the 5th international conference on biotherapy, Würzburg, p 10

    Google Scholar 

  • Gilyova OS, Gibadullina NV, Korobeinikova GA et al (2010) Hirudotherapy in the complex treatment of periodontitis and oral mucosal diseases in patients with systemic cardiovascular pathology. In: Book of abstracts of the 8th international conference on biotherapy, Los Angeles, p 24

    Google Scholar 

  • Gröbe A, Michalsen A, Hanken H, Schmelzle R, Heiland M, Blessmann M (2012) Leech therapy in reconstructive maxillofacial surgery. J Oral Maxillofac Surg 70:221–227

    Article  PubMed  Google Scholar 

  • Grunner OCA (1930) Treatise on the Canon of Medicine of Avicenna incorporating a translation of the first book. Luzac and Co, London

    Google Scholar 

  • Harris CA (1845) The principles and practice of dental surgery. Lindsay & Blackiston, Philadelphia

    Google Scholar 

  • Hartrampf CR, Drazan L, Noel RT (1993) A mechanical leech for transverse rectus abdominis musculocutaneous flaps. Ann Plast Surg 31:103–105

    Article  PubMed  Google Scholar 

  • Haycraft JB (1884) On the action of secretion obtained from the medicinal leech on coagulation of the blood. Proc R Soc Lond 36:478

    Google Scholar 

  • Hayden RE, Phillips JG, McLear PW (1988) Leeches. Objective monitoring of altered perfusion in congested flaps. Arch Otolaryngol Head Neck Surg 114:1395–1399

    Article  PubMed  CAS  Google Scholar 

  • Heldt TJ (1961) Allergy to leeches. Henry Ford Hosp Med Bull 9:498–519

    PubMed  CAS  Google Scholar 

  • Henderson LP, Kuffler DP, Nicholls J, Zhang R (1983) Structural and functional analysis of synaptic transmission between identified leech neurons in culture. J Physiol 340:347–358

    PubMed  CAS  Google Scholar 

  • Hobingh P, Linker A (1999) Hyaluronidase activity in leeches (Hirudinea). Comp Biochem Physiol B Biochem Mol Biol 124:319–326

    Article  Google Scholar 

  • Isakhanjan GS (2003) On the reflex mechanism of action of hirudotherapy. In: Baskova IP (ed) Treatment with leeches and preparations from them, Girudo-Med, Luberzi, pp 22–23

    Google Scholar 

  • Isakhanyan GS (1991) Hirudotherapy in internal medicine. Girudo-Med, Erevan

    Google Scholar 

  • Kalender ME, Comez G, Sevinc A, Dirier A, Camci C (2010) Leech therapy for symptomatic relief of cancer pain. Pain Med 11:443–445

    Article  PubMed  Google Scholar 

  • Kamenev OJ (2001) Wild and artificially grown medical leech and their application in medical practice. In: Practical and experimental hirudology: results in a decade (1991–2001). Book of abstracts of the 7th conference of hirudologists of Russia and CIS, Luberzi, pp 90–92

    Google Scholar 

  • Kamenev OJ (2007) Resources of medicinal leeches (Hirudo medicinalis L.) in the waters of the western Caucasus, and their rational use. Krasnodar

    Google Scholar 

  • Kamenev OJ, Baranovskii AJ (2006) Treatment with leeches. Theory and practice of leeching. Ves', Saint Petersburg

    Google Scholar 

  • Kamenev OJ, Tonkopii VD, Zagrebin AO (2003) Medicinal leeches as a test object for bioidentification of heavy metals in the aquatic environment. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, pp 57–58

    Google Scholar 

  • Karadag AS, Calka O, Akdeniz N, Cecen I (2011) A case of irritant contact dermatitis with leech. Cutan Ocul Toxicol 30:234–235

    Article  PubMed  Google Scholar 

  • Kasimov SS (1961) Clinical and experimental hirudotherapy in treatment of neuritis and neuralgia of sciatic nerve. Izvestia Akademii nauk AzSSR 4:91–95

    Google Scholar 

  • Khardikov AV, Gazazyan MG, Ivanova OJ (2003) Hirudotherapy in treatment of chronic salpingoophoritis. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, p 22

    Google Scholar 

  • Koch CA, Olsen SM, Moore EJ (2012) Use of the medicinal leech for salvage of venous congested microvascular free flaps of the head and neck. Am J Otolaryngol 33:26–30

    Article  PubMed  Google Scholar 

  • Kolesnikova EA, Karzeva TV, Romanova GE et al (1999) The efficacy of hirudotherapy in complex treatment of child neuro-circulatory dystonia. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, p 67

    Google Scholar 

  • Korobeinikova GA (2002) Leeches in complex treatment of patients with essential hypertension and combined oral mucosa lesions in Ust-Katchka Health resort. Perm

    Google Scholar 

  • Krashenjuk AI, Krashenjuk SV (2003) Hirudotherapy treatment of child cerebral palsy. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, p 45

    Google Scholar 

  • Kumar VD, Kumar CP, Kumar SA et al (2012) A critical review on historical aspects of jalaukavacharan (hirudotherapy). IJRAP 3(1), Jan–Feb 2012. http://www.ijrap.net/admin/php/uploads/742_pdf.pdf. Accessed 11 Feb 2012

  • Kuznezova LP, Lusev VA, Volov VA et al (2008) The place of hirudotherapy in complex treatment of chronic heart failure. Russ Cardiol J 2:28–30

    Google Scholar 

  • Lagutenko JP (1981) Structural organization of the trunk brain of annelids: evolutionary neuromorphological analysis. Nauka, Leningrad

    Google Scholar 

  • Lineaweaver WC, Furnas H, Follansbee S, Buncke GH, Whitney TM, Canales F, Bruneteau R, Buncke HJ (1992) Postprandial Aeromonas hydrophila cultures and antibiotic levels of enteric aspirates from medicinal leeches applied to patients receiving antibiotics. Ann Plast Surg 29:245–249

    Article  PubMed  CAS  Google Scholar 

  • Lomaeva BI (2003) The influence of hirudotherapy on haemostatic indices in women suffering from endometriosis. In: Book of abstracts of the 6th international conference on biotherapy, Sivas, pp 26–27

    Google Scholar 

  • Lukin, EI (1976) Leeches. In: Fauna USSR. Academy of Science of the USSR, Moscow

    Google Scholar 

  • Makulova GG (2003) Application of hirudotherapy in patients with Bechterew’s disease. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, pp 29–30

    Google Scholar 

  • Markwardt F (1955) Untersuchungen ueber Hirudin. Naturwissenschaften 52:537

    Article  Google Scholar 

  • Martin F, Dimasi N, Volpari C, Perrera C, Di Marco S, Brunetti M, Steinkühler C, De Francesco R, Sollazzo M (1998) Design of selective eglin inhibitors of HCV NS3 proteinase. Biochemistry 37:11459–11468

    Article  PubMed  CAS  Google Scholar 

  • Marty I, Péclat V, Kirdaite G, Salvi R, So A, Busso N (2001) Amelioration of collagen-induced arthritis by thrombin inhibition. J Clin Invest 107:631–640

    Article  PubMed  CAS  Google Scholar 

  • Menage MJ, Wright G (1991) Use of leeches in a case of severe periorbital haemotoma. Br J Ophthalmol 75:755–756

    Article  PubMed  CAS  Google Scholar 

  • Mercer NS, Beere DM, Bornemisza AJ, Thomas P (1987) Medical leeches as sources of wound infection. Br Med J (Clin Res Ed) 294(6577):93

    Article  Google Scholar 

  • Michalsen A, Deuse U, Esch T et al (2001) Effect of leech therapy (Hirudo medicinalis) in painful osteoarthritis of the knee: a pilot study. Ann Rheum Dis 60:986

    Article  PubMed  CAS  Google Scholar 

  • Michalsen A, Klotz S, Lüdtke R, Moebus S, Spahn G, Dobos GJ (2003) Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med 139:724–730

    Article  PubMed  Google Scholar 

  • Michalsen A, Roth M, Dobos G (2007) Medicinal leech therapy. Thieme Verlag, Stuttgart

    Google Scholar 

  • Mokhov DE, Zalzman SG (2003) Hirudotherapy in neurology. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, pp 39–40

    Google Scholar 

  • Mumcuoglu KY, Pidhorz C, Cohen R, Ofek A, Lipton HA (2007) The use of the medicinal leech, Hirudo medicinalis, in the reconstructive plastic surgery. Internet J Plast Surg 4(2). doi:10.5580/3c6

  • Mumcuoglu KY, Huberman L, Cohen R, Temper V, Adler A, Galun R, Block C (2010) Elimination of symbiotic Aeromonas spp. from the intestinal tract of the medicinal leech, Hirudo medicinalis using ciprofloxacin feeding. Clin Microbiol Infect 16(6):563–567

    Article  PubMed  CAS  Google Scholar 

  • Munro R, Jones C, Sawer R (1991) Calin – a platelet adhesion inhibitor from saliva of the medicinal leech. Blood Coagul Fibrinol 2:179–184

    Article  CAS  Google Scholar 

  • Mutimer KL, Banis JC, Upton J (1987) Microsurgical reattachment of totally amputated ears. Plast Reconstr Surg 79:535–541

    Article  PubMed  CAS  Google Scholar 

  • Muzalevskii VM, Pastel VB, Petrova OV (1999) Complex treatment of neuroosteofibrosis foci in osteochondrosis of vertebra. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, pp 24–25

    Google Scholar 

  • Nikonov GI (1992) Medicinal leech. Yesterday, today, tomorrow. Electronika, Moscow

    Google Scholar 

  • Nikonov GI (1996) Hirudotherapy and hirudopharmacotherapy. Voenizdat, Moscow

    Google Scholar 

  • Orevi M, Rigbi M, Hy-Am E, Matzner Y, Eldor A (1992) A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinalis. Prostaglandins 43:483–485

    PubMed  CAS  Google Scholar 

  • Orevi M, Eldor A, Giguzin Y, Rigbi M (2000) Jaw anatomy of the blood-sucking leeches, Hirudinea Limnatis nilotica and Hirudo medicinalis, and its relationship to their feeding habits. J Zool Lond 250:121–127

    Article  Google Scholar 

  • Poprotskii AV, Aivazov VP, Khinchagov BP (2001) Differential treatment of different forms of dyscirculatory encephalopathy using hirudotherapy in Essentuki. In: Practical and experimental hirudology: results in a decade (1991–2001). Book of abstracts of the 7th conference of hirudologists of Russia and CIS, Luberzi, pp 30–32

    Google Scholar 

  • Poprotskii AV, Aivazov VN, Khinchagov BP et al (2008) Efficiency and safety of hirudotherapy in ischemic cerebrovascular disorders. Vopr Kurortol Fizioter Lech Fiz Kult 4:51–55

    PubMed  Google Scholar 

  • Porshinsky BS, Saha S, Grossman MD, Beery Ii PR, Stawicki SP (2011) Clinical uses of the medicinal leech: a practical review. J Postgrad Med 57:67–71

    Google Scholar 

  • Pospelova ML (2012) Overview of pathogenetic mechanisms of hirudotherapy and the rationale for the treatment of patients with cerebrovascular disease. Sovremennie problem nauki I obrazovania 1. www.science-education.ru/101-5291. Accessed 23 Jan 2013

  • Pospelova ML, Barnaulov OD (2003) Features of hirudotherapy in patients with chronic vertebrobasilar insufficiency. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, pp 35–36

    Google Scholar 

  • Pospelova ML, Barnaulov OD (2006) Hirudotherapy influence on the depression and anxiety rates in cerebrovascular patients. Psychopharmacol Biol Narcol 6:1370–1375

    Google Scholar 

  • Pospelova ML, Barnaulov OD (2010) Hirudotherapy in the treatment of bilateral internal carotid artery occlusion: case report. Curr Top Neurol Psychiatr Relat Discip 18:51–53

    Google Scholar 

  • Pozharizkaya MM, Zidra SI, Dzekh SA et al (2000) Hirudotherapy in complex treatment in patients with the Rossolimo-Melkerssona-Rosenthal syndrome. Stomatologiya dlya vsekh 4:4–6

    Google Scholar 

  • Ptushkin VV, Lapkes TG (2003) Application of hirudotherapy in complex treatment of patients with coronary artery disease and unstable angina. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, pp 15–16

    Google Scholar 

  • Rashidova ES (2003) The experience of hirudotherapy of neurological diseases. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, pp 34–35

    Google Scholar 

  • Rassadina EV (2006) Environmentally sound reproduction biotechnology of Hirudo medicinalis L. in vitro. Uljanovsk

    Google Scholar 

  • Rigbi M (1998) The antihemostatic armamentarium of leech saliva and its therapeutic potential. In: Book of abstracts of the 3rd international conference on biotherapy, Jerusalem, pp 28–29

    Google Scholar 

  • Rigbi M, Jackson CM, Latallo ZS (1988) A specific inhibitor of bovine FaX in the saliva of the leech Hirudo medicinalis. In the 14th international congress of biochemistry, Prague, 10–15 July, FR 037:53

    Google Scholar 

  • Rigbi M, Orevi M, Eldor A (1996) Platelet aggregation and coagulation inhibitors in leech saliva and their roles in leech therapy. Semin Thromb Hemost 22:273–278

    Article  PubMed  CAS  Google Scholar 

  • Salikhov IG (2004) About hirudotherapy in patients with rheumatoid arthritis. Kaz Med J 85:53–55

    Google Scholar 

  • Salzet M (2005) Neuropeptide-derived antimicrobial peptides from invertebrates for biomedical applications. Curr Med Chem 12:3055–3061

    Article  PubMed  CAS  Google Scholar 

  • Sartor C, Limouzin-Perotti F, Legré R, Casanova D, Bongrand MC, Sambuc R, Drancourt M (2002) Nosocomial infections with Aeromonas hydrophila from leeches. Clin Infect Dis 35:1–5

    Article  Google Scholar 

  • Savinov VA, Chaban TN (1995) Comparative characteristics of vascular and reflex phenomena in hirudotherapy. In: Book of abstracts of the 4th conference of association of hirudologists, Moscow, p 21

    Google Scholar 

  • Sawyer RT (1986) Leech biology and behaviour, vol 1–2. Clarendon, Oxford

    Google Scholar 

  • Scheckotov GM (1980) Use of leeches in varicose veins. Voen Med J 3:68

    Google Scholar 

  • Scott K (2002) Is hirudin a potential therapeutic agent for arthritis? Ann Rheum Dis 61:561–562

    Article  PubMed  CAS  Google Scholar 

  • Seemüller U, Meier M, Ohlsson K, Müller HP, Fritz H (1977) Isolation and characterization of a low molecular weight inhibitor (chymotrypsin and human granulocytic elastase and cathepsin G) from leeches. Hoppe Seylers Z Physiol Chem 358:1105–1107

    Article  PubMed  Google Scholar 

  • Seemuller U, Dodt J, Fink E et al (1986) Proteinase inhibitors of the leech Hirudo medicinalis (hirudins, bdellins, eglins). In: Barettand AJ, Salvesen G (eds) Proteinase inhibitors. Elsevier Science Ltd, New York, pp 337–359

    Google Scholar 

  • Semikova TS (1992) Hirudotherapy in treatment of subretinal bleeding (clinical case). Ophtalmokhirurgiya 3:63–64

    Google Scholar 

  • Semikova TS (2011) Complex therapy of acute optic neuritis using antihomotoxic drugs, hirudotherapy and autohemotherapy. In: Book of abstracts of the 2nd world congress on controversies in ophthalmology, Catalonia Palace of Congresses, Barcelona, p 64

    Google Scholar 

  • Semikova TS, Bondareva M (1995) Hirudotherapy in ophthalmology: recommendations for practitioners, Girudo-Med, Moscow

    Google Scholar 

  • Semikova TS, Semikova MV, Jarovoj AJ et al. (1999) Complications and side effects of hirudotherapy in ophthalmology. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, p 47

    Google Scholar 

  • Seselkina TN (2001) Leeches as an early replacement therapy in patients with acute ischemic stroke. In: Practical and experimental hirudology: results in a decade (1991–2001). Book of abstracts of the 7th conference of hirudologists of Russia and CIS, Luberzi, pp 14–16

    Google Scholar 

  • Seselkina TN, Belitskaya RA, Vasilenko GF et al (1998) Hirudoreflexotherapy of acute apoplectic attack. In: Book of abstracts of the 3rd international conference on biotherapy, Jerusalem, p 35

    Google Scholar 

  • Seselkina TN, Belitskaya RA, Vasilenko GF et al. (2003) Efficacy of hirudoreflexotherapy in treatment of patients with ischemic stroke. In: Baskova IP (ed) Treatment with leeches and preparations from them, Girudo-Med, Luberzi, pp 33–38

    Google Scholar 

  • Shenfeld OZ (1999) Successful use of the medicinal leech (Hirudo medicinalis) for the treatment of venous insufficiency in a replanted digit. Isr Med Assoc J 1:221

    PubMed  CAS  Google Scholar 

  • Shipley AE (1927) Historical preface. In: Harding WA, Moore JP (eds) The Fauna of British India: Hirudinea. Taylor and Francis, London

    Google Scholar 

  • Sidorov V, Gilyova OS, Korobeynikova G, Gilyova E, Sidorov D (2003) Hirudotherapy in a combination at UST-Katchka Resort. Sixth international conference on biotherapy, Sivas, p 39

    Google Scholar 

  • Siebeck M, Hoffmann H, Weipert J, Fritz H (1992) Effect of the elastase inhibitor eglin C in porcine endotoxin shock. Circ Shock 36:174–179

    PubMed  CAS  Google Scholar 

  • Smolle J, Cerroni L, Kerl H (2000) Multiple pseudolymphomas caused by Hirudo medicinalis therapy. J Am Acad Dermatol 43:867–869

    Article  PubMed  CAS  Google Scholar 

  • Smoot EC 3rd, Debs N, Banducci D, Poole M, Roth A (1990) Leech therapy and bleeding wound techniques to relieve venous congestion. J Reconstr Microsurg 6:245–250

    Article  PubMed  Google Scholar 

  • Söllner C, Mentele R, Eckerskorn C, Fritz H, Sommerhoff CP (1994) Isolation and characterization of hirustasin - an antistasin-type serin-proteinase inhibitor from the medicinal leech Hirudo medicinalis. Eur J Biochem 219:937–943

    Article  PubMed  Google Scholar 

  • Sommerhoff CP, Söllner C, Mentele R, Piechottka GP, Auerswald EA, Fritz H (1994) A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis. Biol Chem Hoppe Seyler 375:685–694

    Article  PubMed  CAS  Google Scholar 

  • Spizina VI (1987) New treatment method of stomalgia with medicinal leeches. Stomatologiya 1:34–36

    Google Scholar 

  • Stange R, Moser C, Hopfenmueller W (2012) Randomized controlled trial with medical leeches for osteoarthritis of the knee. Complement Ther Med 20:1–7

    Article  PubMed  Google Scholar 

  • Starzeva NV, Lomaeva IB, Beda JV et al (2001) Clinical and lab aspects of hirudotherapy of endometriosis. In: Practical and experimental hirudology: results in a decade (1991–2001). Book of abstracts of the 7th conference of hirudologists of Russia and CIS, Luberzi, pp 28–30

    Google Scholar 

  • Stroganova VA (1999) The experience of hirudotherapy in the practice of pediatrician and child’s neurologist. In: Clinical and experimental hirudology in the new millennium. Book of abstracts of the 6th conference of hirudologists of Russia and CIS, Pyatigorsk, pp 62–65

    Google Scholar 

  • Sulim NI (2003) Hirudotherapy of deforming arthrosis of the temporomandibular joint. In: Hirudo-2003. Book of abstracts of the 3rd conference of hirudologists of Russia and CIS, Moscow, pp 32–33

    Google Scholar 

  • Taylor HS (1860) The family doctor. John Potter, Philadelphia

    Google Scholar 

  • Tuev AV, Koryukina IP, Shutov et al (2001) Treatment methods on Ust-Katchka Health resort. Zvezda, Perm

    Google Scholar 

  • U.S. Food and Drug Administration (FDA) FDA clears medicinal leeches for marketing (2004) FDA Talk Paper. T04-19, Rockville

    Google Scholar 

  • Upshow J, O’Leary JP (2000) The medicinal leech: past and present. Am Surg 66:313–314

    Google Scholar 

  • Utley DS, Koch RJ, Goode RL (1998) The failing flap in facial plastic and reconstructive surgery: role of the medicinal leech. Laryngoscope 108:1129–1135

    Article  PubMed  CAS  Google Scholar 

  • Van Wingerden JJ, Oosthuizen JH (1997) Use of the local leech Hirudo michaelseni in reconstructive plastic and hand surgery. S Afr J Surg 35:29–31

    PubMed  Google Scholar 

  • Varisco PA, Péclat V, van Ness K, Bischof-Delaloye A, So A, Busso N (2000) Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis. Ann Rheum Dis 59:781–787

    Article  PubMed  CAS  Google Scholar 

  • Whitaker IS, Izadi D, Oliver DW, Monteath G, Butler PE (2004) Hirudo medicinalis and the plastic surgeon. Br J Plast Surg 57:348–353

    Article  PubMed  CAS  Google Scholar 

  • Whitaker IS, Oboumarzouk O, Rozen WM, Naderi N, Balasubramanian SP, Azzopardi EA, Kon M (2012) The efficacy of medicinal leeches in plastic and reconstructive surgery: a systematic review of 277 reported clinical cases. Microsurgery 32:240–250

    Article  PubMed  Google Scholar 

  • White RL, Fries CM, Wells MM (2010) Leech therapy: new applications for an old treatment. Nurse. http://ce.nurse.com/ce193-60/leech-therapy-new-applications-for-an-old-treatment/. Accessed 23 Jan 2013

  • Yang T, Peng JR, Zhang HZ (2003) Medicinal uses of a blood-sucking leech, Hirudo nipponia in China. In: Book of abstracts of the 6th international conference on biotherapy, Sivas, p 47

    Google Scholar 

  • Zadorova EV (2003) Hirudotherapy experience in patients with essential hypertension and coronary heart disease. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, pp 16–18

    Google Scholar 

  • Zakharova OA (2008) Pathogenetic substantiation of hirudotherapy in patients with articular form of rheumatoid arthritis. Chita

    Google Scholar 

  • Zaslavskaya SD (1940) Capillary blood-letting as a method of the deep decongestion of internals. Vrach 9:613–616

    Google Scholar 

  • Zavalova LL, Yudina TG, Artamonova II, Baskova IP (2006) Antibacterial non-glycosidase activity of invertebrate destabilase-lysozyme and of its helical amphipat’hic peptides. ∞ 52:158–160

    CAS  Google Scholar 

  • Zhavoronkova NM (1995) Hirudotherapy in complex treatment of Bernhardt-Roth syndrome. In: Book of abstracts of the 4th conference of association of hirudologists. Moscow, p 10

    Google Scholar 

  • Zhavoronkova NM (2003) Hirudotherapy in complex treatment of Dupley’s syndrome. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, p 57

    Google Scholar 

  • Zhivoglyad RN, Nikonov GI (1998) Hirudotherapy of uterine lesions. In: Book of abstracts of the 3rd international conference on biotherapy. Jerusalem, pp 39–40

    Google Scholar 

  • Zhivoglyad RN, Nikonov GI (2003) Comparative analysis of hirudo- and antibiotic therapy in hormone-induced and inflammatory diseases of female genital mutilation. In: Baskova IP (ed) Treatment with leeches and preparations from them. Girudo-Med, Luberzi, p 69

    Google Scholar 

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Correspondence to Olga S. Gileva M.D., Ph.D. .

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Gileva, O.S., Mumcuoglu, K.Y. (2013). Hirudotherapy. In: Grassberger, M., Sherman, R., Gileva, O., Kim, C., Mumcuoglu, K. (eds) Biotherapy - History, Principles and Practice. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6585-6_3

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