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Signaling Pathways of Cbl-b and Its Role in Peripheral T Cell Tolerance

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Trends in Stem Cell Proliferation and Cancer Research

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Abstract

The E3 ubiquitin ligase Cbl-b acts as a key regulator of T cell activation and peripheral tolerance. Cbl-b deficiency uncouples the requirement of CD28 costimulation for T cell activation and exhibits resistance to T cell anergy and tolerance. Cbl-b−/− mice are highly susceptible to autoimmune diseases. Conversely, they mount a robust antitumor response resulting in spontaneous tumor rejection. Therefore, modulation of Cbl-b might provide a unique opportunity for immunotherapeutic strategies for inflammatory disorders, including autoimmunity and cancer.

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Acknowledgments

This work was supported by National Cancer Institute grant 1RC1CA146576-01. I thank Minghui Zeng for help with manuscript preparation.

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Authors and Affiliations

  1. Departments of Oncology, Immunology, and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E. Warren Ave, Mail Code PR04IM, Detroit, MI, 48201, USA

    K. Venuprasad

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  1. K. Venuprasad
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Correspondence to K. Venuprasad .

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Editors and Affiliations

  1. Instituto de Ciências Biológicas, Departamento de Bioquímica, Universidade Federal de Minas Gerais, Belo Horizonte, São Paulo, Brazil

    Rodrigo R. Resende

  2. Depto. Bioquímica, Universidade de São Paulo Inst. Química, São Paulo, São Paulo, Brazil

    Henning Ulrich

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Venuprasad, K. (2013). Signaling Pathways of Cbl-b and Its Role in Peripheral T Cell Tolerance. In: Resende, R., Ulrich, H. (eds) Trends in Stem Cell Proliferation and Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6211-4_8

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