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Nucleolar Localization/Retention Signals

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Proteins of the Nucleolus

Abstract

Most nuclear proteins are highly dynamic and are able to accumulate inside specific non-membrane-bound domains. A current key question is how macromolecules find and accumulate at nuclear target sites that are not separated from the nucleoplasm by membranes. According to recent findings, nucleolar localization results from nucleolar retention rather than targeting to this compartment. Here, we discuss recent data concerning nucleolar retention via so-called nucleolar localization/retention signals (NoLS/NoRS).

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Acknowledgments

We are grateful to Dr. G. Wahl for providing histone H2B-EGFP construct. We thank E. Senchenkov, A. Lazarev, and M. Mogilnikov for technical support and S. Golyshev, A. Tuzhikov, V. Polyakov, O. Lisitsyna, and E. Kananykhina for discussion of results. This work was supported by grant from Russian Foundation for Basic Research (12-04-01237) and grant from OPTEC Ltd. (Moscow).

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  1. A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia

    Eugene V. Sheval & Yana R. Musinova

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  1. Eugene V. Sheval
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Correspondence to Eugene V. Sheval .

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  1. , Biology, University of Toronto at Mississauga, Mississauga Rd. N. 3359, Mississauga, L5L1C6, Ontario, Canada

    Danton H O'Day

  2. , Biology, University of Toronto at Mississauga, Mississauga Rd. 3359, Mississauga, L5L1C6, Ontario, Canada

    Andrew Catalano

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Sheval, E.V., Musinova, Y.R. (2013). Nucleolar Localization/Retention Signals. In: O'Day, D., Catalano, A. (eds) Proteins of the Nucleolus. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5818-6_8

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