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Pineal Parenchymal Tumors: Diagnostics and Prognosis

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Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

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Abstract

Pineal parenchymal tumors (PPTs) are ­heterogeneous population of rare tumors with hard-to-predict clinical outcome. Their diagnosis is also problematic, as there are no specific and characteristic markers. Radiological imaging is mostly useful; however it does not give enough data about tumor type. There is a strong need to work out methods enabling as well earlier recognition and better prognosis of outcome of the disease as assessment of therapeutic effectiveness. In this chapter we summarize present, however still very limited, information about PPTs.

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References

  • Ahn ES, Goumnerova L (2010) Endoscopic biopsy of brain tumors in children: diagnostic success and utility in guiding treatment strategies. J Neurosurg Pediatr 5:255–262

    Article  PubMed  Google Scholar 

  • Al-Holou wN, Maher CO, Muraszko KM, Garton JL (2010) The natural history of pineal cysts in children and young adults. J Neurosurg Pediatr 5:162–166

    Article  PubMed  Google Scholar 

  • Boco T, Aalaei S, Musacchio M, Byrne R, Cochran E (2008) Papillary tumor of the pineal region. Neuropathology 28:87–92

    Article  PubMed  Google Scholar 

  • Cho BK, Wang KC, Nam DH, Kim DG, Jung HW, Kim HJ, Han DH, Choi KS (1998) Pineal tumors: experience with 48 cases over 10 years. Childs Nerv Syst 14:53–58

    Article  PubMed  CAS  Google Scholar 

  • Engel U, Gottschalk S, Niehaus L, Lehmann R, May C, Vogel S, Janisch W (2000) Cystic lesions of the pineal region – MRI and pathology. Neuroradiology 42:399–402

    Article  PubMed  CAS  Google Scholar 

  • Deshmukh VR, Smith KA, Rekate HL, Coons S, Spetzler RF (2004) Diagnosis and management of pineocytomas. Neurosurgery. 55:349–55; discussion 355–357

    Google Scholar 

  • Fauchon F, Jouvet A, Paquis P, Saint-Pierre G, Mottolese C, Hassel MB, Chauveinc L, Sichez J, Philippon J, Schlienger M, Bouffet E (2000) Parenchymal pineal tumors: a clinicopathological study of 76 cases. Int J Radiat Oncol Biol Phys 46:959–968

    Article  PubMed  CAS  Google Scholar 

  • Ferrer E, Santamarta D, Garcia-Fructuoso G, Caral L, Rumia J (1997) Neuroendoscopic management of pineal region tumors. Acta Neurochir (Wien) 139:12–21

    Article  CAS  Google Scholar 

  • Fèvre-Montange M, Szathmari A, Champier J, Mokhtari K, Chrétien F, Coulon A, Figarella-Branger D, Polivka M, Varlet P, Uro-Coste E, Fauchon F, Jouvet A (2008) Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol 18:354–359

    Article  PubMed  Google Scholar 

  • Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, Akimoto J, Tanaka M, Okada Y, Saito S (2010) Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. J Neuropathol Exp Neurol 69:498–510

    Article  PubMed  CAS  Google Scholar 

  • Hirato J, Nakazato Y (2001) Pathology of pineal region tumors. J Neuroncol 54:239–249

    Article  CAS  Google Scholar 

  • Hoffman HJ, Yoshida M, Becker LE, Hendrick EB, Humphreys RP (1994) Pineal region tumours in childhood. Pediatr Neurosurg 21:91–104

    Article  PubMed  CAS  Google Scholar 

  • Jouvet A, Fevre-Montange M, Besancon R, Derrington E, Saint-Pierre G, Belin MF, Pialat J, Lapras C (1994) Structural and ultrastructural characteristics of human pineal gland, and pineal parenchymal tumors. Acta Neuropathol 88:334–348

    Article  PubMed  CAS  Google Scholar 

  • Kang JK, Jeun SS, Hong YK, Park CK, Son BC, Lee IW, Kim MC (1998) Experience with pineal region tumors. Childs Nerv Syst 14:63–68

    Article  PubMed  CAS  Google Scholar 

  • Karasek M, Mandera M, Papierz W (2007) Pineal region tumors. In: Pandi-Perumal SR, Cardinali DP (eds) Melatonin: from molecules to therapy. Nova Science Publishers, Inc, New York, pp 483–497

    Google Scholar 

  • Kawahara I, Tokunaga Y, Yagi N, Iseki M, Abe K, Hayashi T (2007) Papillary tumor of the pineal region. Neurol Med Chir (Tokyo) 47:568–571

    Article  Google Scholar 

  • Kim BS, Kim DK, Park SH (2009) Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. Neuropathology 29:602–608

    Article  PubMed  Google Scholar 

  • Kleihues P, Cavenee WK (2000) Pathology and genetics of tumors of the nervous system. IARC Press, Lyon, pp 115–121

    Google Scholar 

  • Lapras C, Mottolesese C, Jouvet A (1999) Pineal region tumors. In: Choux M, Di Rocco C, Hockley A, Walker M (eds) Pediatric neurosurgery. Churchill Livingstone, London, pp 549–560

    Google Scholar 

  • Lekovic GP, Gonzalez LF, Shetter AG, Porter RW, Smith KA, Brachman D, Spetzler RF (2007) Role of Gamma Knife in the management of pineal region tumors. Neurosurg Focus 23(6):E12

    Article  PubMed  Google Scholar 

  • Luther N, Stetler WR Jr, Dunkel IR, Christos PJ, Wellons JC III, Souweidame MM (2010) Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy. J Neurosurg Pediatr 5:61–67

    Article  PubMed  Google Scholar 

  • Mandera M, Bazowski P (2004) Surgical management of pineal region tumors in children. J Pediatr Neonat 1:36–40

    Google Scholar 

  • Mandera M, Bażowski P, Wencel T, Dec R (1999) Melatonin secretion in patients with pineal region tumors – preliminary report. Neuroendocrinol Lett 20:167–170

    PubMed  CAS  Google Scholar 

  • Mandera M, Marcol W, Bierzyńska-Macyszyn G, Kluczewska E (2003) Pineal cysts in childhood. Childs Nerv Syst 19:750–755

    Article  PubMed  Google Scholar 

  • Marcol W, Kotulska K, Grajkowska W, Gołka D, Właszczuk P, Drogosiewicz M, Mandera M, Lewin-Kowalik J, Roszkowski M (2007) Papillary pineocytoma in child: case report. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 151:121–123

    Article  PubMed  Google Scholar 

  • Mena H, Rushing EJ, Ribas JL, Delahunt B, McCarthy WF (1995) Tumors of pineal parenchymal cells: a correlation of hitological features, including nucleolar organizer regions, with survival in 35 cases. Hum Pathol 26:20–30

    Article  PubMed  CAS  Google Scholar 

  • Mena H, Nakazato Y, Jouvet A, Scheithauer BW (2000) Pineal parenchymal tumours. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 115–121

    Google Scholar 

  • Oi S, Shibata M, Tominaga J, Honda Y, Shinoda M, Takei F, Tsugane R, Matsuzawa K, Sato O (2000) Efficacy of neuroendoscopic procedures in minimally invasive preferential management of pineal region tumors: a prospective study. J Neurosurg 93:245–253

    Article  PubMed  CAS  Google Scholar 

  • Regis J, Bouillot P, Rouby-Volot F, Figarella-Branger D, Dufour H, Peragut JC (1996) Pineal region tumors and the role of stereotactic biopsy: review of mortality, morbidity and diagnostic rates un 370 cases. Neurosurgery 39:907–914

    PubMed  CAS  Google Scholar 

  • Russel DS, Rubinstein LJ (1977) Pathology of tumors of the nervous system. Williams and Wilkins, Baltimore, pp 284–295

    Google Scholar 

  • Sano K (1983) Pineal region tumors: problems in pathology and treatment. Clin Neurosurg 30:59–91

    Google Scholar 

  • Sato K, Kubota T (2009) Pathology of pineal parenchymal tumors. Prog Neurol Surg 23:12–25

    Article  PubMed  Google Scholar 

  • Satoh H, Uozumi T, Kiya K, Kurisu K, Arita K, Sumida M, Ikawa F (1995) MRI of pineal region tumours: relationship between tumours and adjacent structures. Neuroradiology 37:624–630

    Article  PubMed  CAS  Google Scholar 

  • Sawamura Y, Ikeda J, Ozawa M, Minoshima Y, Saito H, Abe H (1995) Magnetic resonance images reveal a high incidence of asymtomatic pineal cysts in young women. Neurosurgery 37:11–15

    Article  PubMed  CAS  Google Scholar 

  • Schild SE, Scheithauer BW, Scomberg PJ, Hook CC, Kelly PJ, Frick L, Robinow JS, Biskirk SJ (1993) Pineal parenchymal tumors. Clinical, pathologic and therapeutic aspects. Cancer 72:870–880

    Article  PubMed  CAS  Google Scholar 

  • Shibamoto Y, Oda Y, Yamashita J, Takahashi M, Kikuchi H, Abe M (1994) The role of cerebrospinal fluid cytology in radiotherapy planning for intracranial germinoma. Int J Radiat Oncol Biol Phys 29:1089–1094

    Article  PubMed  CAS  Google Scholar 

  • Tien RD, Barkowich AJ, Edwards MS (1990) MR imaging of pineal tumors. Am J Neuroradiol 11:557–565

    Google Scholar 

  • Trojanowski JQ, Tascos NA, Rorke LB (1982) Malignant pineocytoma with prominent papillary features. Cancer 50:1789–1793

    Article  PubMed  CAS  Google Scholar 

  • Tsumanuma I, Tanaka R, Ichikawa T, Washiyama K, Kumanishi T (2000) Demonstration of hydroxyindole-O-methyltransferase (HIOMT) mRNA expression in pineal parenchyma tumors: histochemical in situ hybridization. J Pineal Res 28:203–209

    Article  PubMed  CAS  Google Scholar 

  • Vorkapic P, Waldhauser F, Bruckner R, Biegelmayer C, Schmidbauer M, Pendl G (1987) Serum melatonin levels: a new neurodiagnostic tool in pineal region tumors? Neurosurgery 21:817–824

    Article  PubMed  CAS  Google Scholar 

  • Washiyama K, Sekiguchi K, Tanaka R, Yamazaki K, Kumanishi T, Oyake Y (1987) Immunohitochemical study on AFP, HCG, and PLAP in primary intracranial germ cell tumors. Prog Exp Tumor Res 30:296–306

    PubMed  CAS  Google Scholar 

  • Webb SM, Puig-Domingo M (1995) Role of melatonin in health and disease. Clin Endocrinol 42:221–234

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology, Medical University of Silesia, Katowice, Poland

    Wiesław Marcol & Joanna Lewin-Kowalik

  2. Division of Neurosurgery, Department of Pediatric Surgery, Medical University of Silesia, Katowice, Poland

    Marek Mandera

  3. Translational Medicine Division, Brigham and Women’s Hospital, Boston, MA, USA

    Izabela Malinowska

  4. Department of Neurosurgery, Provincial Specialistic Hospital, Jastrzebie-Zdroj, Poland

    Grzegorz Kiwic

Authors
  1. Wiesław Marcol
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  2. Marek Mandera
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  3. Joanna Lewin-Kowalik
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  4. Izabela Malinowska
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  5. Grzegorz Kiwic
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Corresponding author

Correspondence to Wiesław Marcol .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Marcol, W., Mandera, M., Lewin-Kowalik, J., Malinowska, I., Kiwic, G. (2013). Pineal Parenchymal Tumors: Diagnostics and Prognosis. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_5

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  • DOI: https://doi.org/10.1007/978-94-007-5681-6_5

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5680-9

  • Online ISBN: 978-94-007-5681-6

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