Abstract
Patients undergoing high-dose chemotherapy for CNS lymphomas are predisposed to thiamine deficiency. With the presence of pre-existing neurological deficits and the lack of a definitive diagnostic test the complications of Wernicke’s encephalopathy and Korsakoff’s dementia are easily missed. Clinicians should be aware of thiamine deficiency as a differential diagnosis for neurological or cardiovascular deterioration is PCNSL patients. We propose that prophylactic, parenteral thiamine should be administered to all patients receiving second-line anti-emetic therapy during high-dose chemotherapy for CNS malignancy.
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© 2012 Springer Science+Business Media Dordrecht
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Richardson, S.E., McNamara, C. (2012). Thiamine Deficiency Complicating the Treatment of Primary CNS Lymphoma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 9. Tumors of the Central Nervous System, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5488-1_6
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DOI: https://doi.org/10.1007/978-94-007-5488-1_6
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