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Patterns and Trends in HPV-Related Oral Cancer and Other HPV-Associated Cancers

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HPV and Cancer

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Abstract

Relative to the rather established association of anogenital cancer burden to HPV in the United States, the role of HPV in head and neck and specifically oral/oropharyngeal cancers remains controversial. There have been extrapolations made that increasing prevalence of HPV is the cause of increasing incidence rates in some cancers of the head and neck region. As the association of HPV has been more distinctly defined with other cancers, including the development and initiation of vaccines against HPV, monitoring oral/oropharyngeal cancers should follow that of the other cancers. Herein, we aim to learn from the US status with other HPV associated cancers, to help inform us about the relative status of HPV-oral cancer, in the window of the introduction of the HPV vaccine.

An assessment of incidence and mortality/survival rates from the most recently available SEER incidence and US mortality data (1992–2008) for Oral Cancer and several other HPV-associated cancers provides the basis for comparisons. The HPV-related cancer sites for analyses were those sites and subsites currently known or thought to be etiologically related to HPV exposures. Additionally for comparison purposes, sites unrelated to HPV were selected and included in the analysis. The patterns and trends seen in the SEER data merit continued monitoring for shared etiological factors across cancer sites and subsites. The establishment of HPV detection standards is needed. Sexual behaviors and HPV vaccination data are warranted for inclusion in personal health, including oral health, histories.

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Abbreviations

APC:

Annual percentage change

BMI:

Body mass index

HPV:

Human papillomavirus

INHANCE:

International Head and Neck Cancer Consortium

NCHS:

US National Center for Health Statistics

OC:

Oral cancer

OCP:

Oral cavity and pharynx

OCPC:

Oral cavity and pharyngeal cancer

OP:

Oral/orophyarnx

OR:

Odds ratio

OSCC:

Oral squamous cell carcinoma

PC:

Total percentage change

SEER:

Surveillance Epidemiology and End-Results

SCC:

Squamous cell carinoma

US:

United States of America

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Authors and Affiliations

  1. College of Dentistry, Department of Pediatric Dentistry, School of Public Health, Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL, USA

    Linda M. Kaste

  2. School of Public Health, Division of Epidemiology and Biostatistics, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA

    Therese A. Dolecek

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Correspondence to Linda M. Kaste .

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    James A. Radosevich

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Kaste, L.M., Dolecek, T.A. (2012). Patterns and Trends in HPV-Related Oral Cancer and Other HPV-Associated Cancers. In: Radosevich, J. (eds) HPV and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5437-9_5

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