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B Cell Growth, Differentiation and Malignancies

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Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics

Part of the book series: Cancer Growth and Progression ((CAGP,volume 14))

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Abstract

The primary function of a B cell (or lymphocyte) is to produce large quantity of secreted immunoglobulin (also known as antibody) to fight against bacteria, viruses and other foreign insults to the human body. Each B cell makes only one distinct immunoglobulin which recognizes a cognate antigen. It is estimated that B cells in the human body can produce as many as 1011 different antibodies. Thus, each B cell must undergo a series of differentiation, selection and maturation processes before it is endowed with the ability to produce a functional immunoglobulin to represent in the large and diverse antibody repertoire. While insufficient B cells and insufficient antibody production can thus lead to infections, uncontrolled growth of B cells can lead to leukemia and lymphoma. In this article, we will focus on transcription factors and signaling molecules that involve in normal B cell development and differentiation. These molecules, when mutated or not tightly regulated, will contribute the formation of B cell malignancies.

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Authors and Affiliations

  1. Hematopathology and Laboratory Medicine, Hematologic Malignancies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA

    Jianguo Tao M.D., Ph.D.

  2. Immunology Program, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Chih-Chi Andrew Hu Ph.D.

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  1. Jianguo Tao M.D., Ph.D.
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  2. Chih-Chi Andrew Hu Ph.D.
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Correspondence to Chih-Chi Andrew Hu Ph.D. .

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  1. Research Institute, Department of Hematopathology and, H. Lee Moffitt Cancer Center &, Magnolia Drive - MCC-LAB 12902, Tampa, 33612, Florida, USA

    Jianguo Tao

  2. Research Institute, Department of Malignant Hematology, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, Florida, USA

    Eduardo Sotomayor

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Tao, J., Hu, CC.A. (2012). B Cell Growth, Differentiation and Malignancies. In: Tao, J., Sotomayor, E. (eds) Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics. Cancer Growth and Progression, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5028-9_1

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