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Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma

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Novel Apoptotic Regulators in Carcinogenesis

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Abstract

Today, this is an established fact that like other organs, normal breast development is also used to be monitored by a balance between cell proliferation and apoptosis. As a consequence, tumor growth is not an outcome of abnormal cell proliferation only, but of reduced apoptosis, too. Apoptosis or programmed cell death maintains the integrity of a healthy individual, while dysregulation of this mechanism becomes crucial for the pathophysiology of tumorigenesis. Bcl-2 family of proteins, caspaes, IAP family of proteins, TNF superfamily members are the important regulators of apoptotic signaling pathways. Therefore, several therapeutic agents have been exploited targeting these apoptotic pathways. The review has been concentrated on physiology and pathophysiology of different apoptotic regulators and their therapeutic intervention towards breast cancer.

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  1. Department of Pharmaceutical Technology, Jadavpur University, Kolkata-32, West Bengal, India

    Subhadeep Das & Malay Chatterjee

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  1. , Surgery, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, Hong Kong SAR

    George G. Chen

  2. , Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

    Paul B.S. Lai

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Das, S., Chatterjee, M. (2012). Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma. In: Chen, G., Lai, P. (eds) Novel Apoptotic Regulators in Carcinogenesis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4917-7_9

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