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Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Example

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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Part of the book series: Subcellular Biochemistry ((SCBI,volume 63))

Abstract

The regulated export of nascent G protein coupled receptors (GPCRs) from intracellular stores is an emerging concept with important implications in cell biology and pharmacology. This phenomenon requires a complex network of interactions between GPCRs with either chaperones and escort proteins or gatekeepers, which are respectively involved in the progression of GPCRs along the biosynthetic pathway to the plasma membrane or in their retention in intracellular compartments. The regulated export of GPCRs is also controlled by external stimuli and might represent an adaptive mechanism to specific physiological constraints, such as the sustained activation of the CCR5 chemokine receptor in the context of chemotaxis.

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Acknowledgements

The authors thank Dr Hervé Enslen for the critical reading of the manuscript. This work is supported by a grant (#R09158KK) of the Agence Nationale de la Recherche sur le SIDA (ANRS) to SM

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Authors and Affiliations

  1. Institut Cochin, Université Paris Descartes, CNRS (UMR8104), 27 rue du Fg. St. Jacques, 75014, Paris, France

    Hamasseh Shirvani, Gabriel Gätà & Stefano Marullo

  2. Université Paris Diderot, INSERM U1016, Paris, France

    Hamasseh Shirvani, Gabriel Gätà & Stefano Marullo

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  1. Hamasseh Shirvani
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  2. Gabriel Gätà
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  3. Stefano Marullo
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Correspondence to Stefano Marullo .

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Editors and Affiliations

  1. Faculty of Medicine, Pharmacology, Dalhousie University, College Street 5968, Halifax, B3H 4R2, Nova Scotia, Canada

    Denis J. Dupré

  2. , Pharmacology and Therapeutics, McGill University, Promenade Sir William Osler 3655, Montreal, H3G 1Y6, Québec, Canada

    Terence E. Hébert

  3. Institut Cochin, Rue Méchain 22, Paris, 75014, France

    Ralf Jockers

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Shirvani, H., Gätà, G., Marullo, S. (2012). Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Example. In: Dupré, D., Hébert, T., Jockers, R. (eds) GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. Subcellular Biochemistry, vol 63. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4765-4_6

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