Abstract
This chapter presents the classification of chaperones, their molecular properties among which that of forming functional complexes involving various molecules, and their distribution inside and outside the cell. The chaperone genes in the human genome are listed and briefly described, focusing on the small heat-shock proteins (sHsp), Hsp60, Hsp70, and Hsp90, and mentioning all others known. The chapter also introduces the concept of chaperoning system, i.e., the physiological system of an organism which is composed of all its chaperones, co-chaperones, and chaperone co-factors.
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Further Reading
See also Chap. 1 for Further Reading
Sections 2.1–2.4 Clusterin
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Alpha Synuclein and Myocilin
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AIPL1 Part of Chaperone Complex
AIPL1 (aryl hydrocarbon-interacting receptor protein-like 1)
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AIP
AIP (aryl-hydrocarbon receptor-interacting protein; or aryl hydrocarbon receptor-associated protein 9, ARA9)
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Torsin
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AHSP (Alpha-Hemoglobin-Stabilizing Protein)
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Hsp10
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Chaperoning Networks: Balance Between Protein Folding and Degradation
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CHAPERONES: REALM CCT, The Cytosolic Chaperonin is also Present in the Nucleus and Perform Functions Other than the Canonical Protein Folding
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Chaperones on the Surface of Tumor Cells
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Saliva and Serum Hsp60
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ER chaperones are Also Outside the Organelle
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How Many Chaperones in the Human Species?
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Section 2.5 The Chaperonin System and Non-chaperoning Complexes Formed by Chaperones (see also Further Reading in Sects. 7.3–7.4)
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Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B (2013) Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition. Mol Hum Reprod 19:120–135. doi:10.1093/molehr/gas064
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Macario, A.J., Conway de Macario, E., Cappello, F. (2013). Chaperones: General Characteristics and Classifications. In: The Chaperonopathies. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4667-1_2
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DOI: https://doi.org/10.1007/978-94-007-4667-1_2
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