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Mobilization of Pluripotent Stem Cells in Patients with Myocardial Ischemia: From the Bench to Bedside

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Stem Cells and Cancer Stem Cells, Volume 7

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 7))

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Abstract

Acute myocardial infarction and the following ischemic heart disease remain a major cause of mortality and morbidity in the western world. Despite the advances in pharmacological and reperfusion therapies, replacing the infarcted myocardial tissue remain illusive to scientist and clinicians alike. Adult bone marrow harbors a multitude of hematopoietic and non-hematopoietic stem cells including a small subset of primitive cells such as very small embryonic like stem cells (VSELs) that carry a number of features resembling embryonic stem cells. Myocardial ischemia initiates multiple innate mechanisms that culminate in the mobilization of bone marrow-derived cells including differentiated lineage as well as undifferentiated stem cells. While the numbers of stem cells carrying pluripotent features among the mobilized stem cells is small, their differentiation and regeneration capacity appear immense. Future therapies aiming at selective mobilization of the pluripotent and primitive subsets of bone marrow-derived cells during myocardial ischemia are needed.

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Acknowledgments

Dr. Abdel-Latif is supported by the University of Kentucky Clinical and Translational Science Pilot Award and the University of Kentucky Clinical Scholar program.

Dr. Zuba-Surma is supported by the “Polish Foundation of Science” homing program grant number 2008/15.

Dr. Ratajczak is supported by NIH grant R01 CA106281, NIH R01 DK074720, and Stella and Henry Endowment.

We thank Dr. Karapetyan for her technical support.

Conflict of interest: None.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, University of Kentucky, 740 S. Limestone Street, Lexington, KY, 40536-0200, USA

    Ahmed Abdel-Latif

  2. Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland

    Ewa K. Zuba-Surma

  3. Stem Cell Biology Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    Mariusz Z. Ratajczak

Authors
  1. Ahmed Abdel-Latif
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  2. Ewa K. Zuba-Surma
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  3. Mariusz Z. Ratajczak
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Correspondence to Ahmed Abdel-Latif .

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Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Abdel-Latif, A., Zuba-Surma, E.K., Ratajczak, M.Z. (2012). Mobilization of Pluripotent Stem Cells in Patients with Myocardial Ischemia: From the Bench to Bedside. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Stem Cells and Cancer Stem Cells, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4285-7_6

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