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Utility of Mesenchymal Stem Cell Therapy in Type 1 Diabetes

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

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Abstract

Clinical trials are underway to test the therapeutic efficacy of mesenchymal stem cells (MSCs) in a number of diseases with no curative therapy available, including type 1 diabetes mellitus (T1D). Due to their plasticity, MSCs first gained interest in cell-based tissue engineering; however, given their low immunogenicity and profound immunodulatory effects, MSCs are now receiving much attention as a cell-based therapy for immune-mediated disorders. The use of MSCs in T1D holds potential in three different disciplines: systemic injection of MSCs to suppress autoreactive T cells; co-transplantation with islet allografts to enhance islet engraftment in an immuno-privileged microenvironment; and differentiation of MSCs into insulin-producing cells (IPC). We are focusing on the potential translation of MSCs therapy for clinical development to treat T1D.

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Abbreviations

BM:

Bone marrow

GVHD:

Graft-versus-host disease

HSCs:

Hematopoietic stem cells

hBM-MSC:

Human bone marrow-derived MSC

IPC:

Insulin-producing cells

MSCs:

Mesenchymal stem cells

T1D:

Type 1 diabetes

STZ:

Streptozoticin

UBC:

Umbilical cord blood

UC:

Umbilical cord tissue

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Authors and Affiliations

  1. Brigham & Women’s Hospital, Transplantation Research Center, EBRC, 221 Longwood Avenue 3 Floor, Boston, MA, 02115, USA

    Robert F. Moore, Marwan Mounayar & Reza Abdi

Authors
  1. Robert F. Moore
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  2. Marwan Mounayar
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  3. Reza Abdi
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Corresponding author

Correspondence to Reza Abdi .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Moore, R.F., Mounayar, M., Abdi, R. (2012). Utility of Mesenchymal Stem Cell Therapy in Type 1 Diabetes. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_17

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