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The Biology and Regenerative Potential of Stem Cells and Their Mesenchymal Progeny

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

Abstract

Stem cells represent a promising novel therapeutic modality for the treatment of devastating diseases with high unmet medical need. Amongst the various types of stem cells, adult mesenchymal stromal cells (MSCs) emerged as cells with unique biological properties making them candidates for the treatment of autoimmune or inflammatory diseases or e.g. progressive organ failure. Here, the history of MSCs in the context of hematopoiesis and bone marrow transplantation, their in vivo origin in mesenchymal compartments, and their in vitro properties are highlighted. Proposed modes of action of MSCs and deduced potential targets of MSC therapy are discussed. Last but not least, an overview of the current status of cellular therapy approaches and future prospects is given regarding clinical testing of cells and future technological opportunities.

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Authors and Affiliations

  1. Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany

    Markus Neubauer, Heike Wegmeyer & Ralf Huss

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  1. Markus Neubauer
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  2. Heike Wegmeyer
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  3. Ralf Huss
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Correspondence to Markus Neubauer .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Neubauer, M., Wegmeyer, H., Huss, R. (2012). The Biology and Regenerative Potential of Stem Cells and Their Mesenchymal Progeny. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_13

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