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Propagation of Human Embryonic Stem Cells: Role of TGF β

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

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Abstract

Human embryonic stem cells (hES) have tremendous application in several areas of research including regenerative medicine, developmental biology, drug screening, and drug discovery. Transforming Growth Factor (TGF) β and its family of proteins have an indispensible role in genesis and maintenance of various organs and cancer and are also used for the propagation of embryonic stem cells. In this review, we discuss the TGF β family members, and their signalling, and delve into the molecular mechanism by which TGF β proteins may regulate the propagation of human embryonic stem cells.

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Authors and Affiliations

  1. Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, 400 012, India

    Prasad Pethe & Deepa Bhartiya

Authors
  1. Prasad Pethe
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  2. Deepa Bhartiya
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Corresponding author

Correspondence to Deepa Bhartiya .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Pethe, P., Bhartiya, D. (2012). Propagation of Human Embryonic Stem Cells: Role of TGF β. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_1

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