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Pediatric Supratentorial Primitive Neuroectodermal Tumor: Treatment with Chemotherapy and Radiation

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Pediatric Cancer, Volume 2

Part of the book series: Pediatric Cancer ((PECA,volume 2))

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Abstract

Supratentorial primitive neuroectodermal tumors (SPNET) are rare embryonal tumors of the central nervous system that account for only 2.5% of brain tumors in children. This tumor has proven to be difficult to treat, with published survival rates ranging from 17% to 57%. The current therapy for pediatric patients with SPNET used by most clinicians is a combination of both chemotherapy and radiation therapy. Studies have shown a significant improvement in survival for patients with this tumor type if radiation therapy is utilized. The role of high dose chemotherapy followed by stem cell rescue is emerging as potentially effective therapy for these tumors. Overall, SPNET has had a low survival rate, but more recent studies have shown an improvement in the survival of pediatric patients with SPNET.

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Authors and Affiliations

  1. Division of Neurology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada

    Donna L. Johnston & Daniel L. Keene

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  1. Donna L. Johnston
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  2. Daniel L. Keene
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Correspondence to Donna L. Johnston .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Johnston, D.L., Keene, D.L. (2012). Pediatric Supratentorial Primitive Neuroectodermal Tumor: Treatment with Chemotherapy and Radiation. In: Hayat, M. (eds) Pediatric Cancer, Volume 2. Pediatric Cancer, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2957-5_22

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