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Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids

Inorganic Nanoparticle as a Viral Capsid Carrier

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Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism

Abstract

Virus like particles (VLP) are used to transport immune response-modulating agents to target cells to treat them. In order to deliver a high concentration of VLP to the cell, a number of VLP can be attached to a nanoparticle to be used as a nanolorry. In this study, SiO2 nanoparticles were attached to Hepatitis B VLP. Spectrophotometry measurements, electron, and fluorescent microscopy evidence showed that the SiO2 – Hepatitis B VLP complexes were formed.

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References

  1. Virus Particle Explorer. Human Hepatitis B Viral Capsid. http://viperdb.scripps.edu/info_page.php?VDB=1qgt

  2. He-sheng C, Zhen-ya S, Li-hui X (2004) Properties of nano SiO2 modified PVF adhesive. J Wuhan Univ Technol Mater Sci Ed 19:73–75

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Author information

Authors and Affiliations

  1. Biomedical Research and Study Centre, Riga, Latvia

    Yu. Dekhtyar, D. Skrastiņa, R. Reinhofa & P. Pumpens

  2. Institute of Biological Engineering and Nanotechnology, Riga Technical University, Kalku Str. 1, Riga, Latvia

    M. Romanova & A. Kachanovska

  3. University of Latvia, Riga, Latvia

    A. Patmalnieks

Authors
  1. Yu. Dekhtyar
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  2. M. Romanova
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  3. A. Kachanovska
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  4. D. Skrastiņa
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  5. R. Reinhofa
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  6. P. Pumpens
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  7. A. Patmalnieks
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Corresponding author

Correspondence to M. Romanova .

Editor information

Editors and Affiliations

  1. , NUARI, Institute for Advanced Sciences Converge, 13873 Park Center Rd, Suite 500, Herndon, 20171, Virginia, USA

    Ashok Vaseashta

  2. Norwich University Applied Research Inst, 158 Harmon Dr., Northfield, 05663, Vermont, USA

    Eric Braman

  3. Norwich University Applied Research Inst, 158 Harmon Dr., Northfield, 05663, Vermont, USA

    Philip Susmann

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© 2012 Springer Science+Business Media B.V.

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Dekhtyar, Y. et al. (2012). Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids. In: Vaseashta, A., Braman, E., Susmann, P. (eds) Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2488-4_23

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