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The Roles of Nanog During Early Fish Embryonic Development and Primordial Germ Cell Migration

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Stem Cells and Cancer Stem Cells,Volume 3

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

Abstract

Embryonic stem cells (ESCs) present a potential important source for new therapies in regenerative medicine. To fully extract their potential, we need to understand the molecular mechanisms that regulate pluripotency in its natural environment: the embryo. Nanog, along with Oct4 and Sox2, is a key transcription factors (TFs) regulating pluripotency in ESCs in vitro, and its role in vivo has been studied primarily in mice and more recently, in medaka fish (Oryzias latipes). In this chapter, we review the complementary data provided by the two animal models to explain the different roles of Nanog during embryonic development. The use of medaka to study of Nanog allowed us to complement the murine model and provide new evidence for the roles of Nanog in cell cycle regulation and primordial germ cell migration through the regulation of Cxcr4b.

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Authors and Affiliations

  1. Instituto de Investigación Sanitaria Hospital La Fe, 46009, Valencia, Spain

    Ana V. Sánchez-Sánchez & José L. Mullor

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  1. Ana V. Sánchez-Sánchez
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  2. José L. Mullor
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Correspondence to José L. Mullor .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Sánchez-Sánchez, A.V., Mullor, J.L. (2012). The Roles of Nanog During Early Fish Embryonic Development and Primordial Germ Cell Migration. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_9

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