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Evidence-based Anticancer Materia Medica for Prostate Cancer

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Materia Medica for Various Cancers

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 2))

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Abstract

Prostate cancer is a leading cause of cancer death in men in Western countries. Although progress has been made in therapies for cases where there is early diagnosis and disease is localized, current therapies for advanced prostate cancer still remain inadequate and do not provide a cure. Due to the particularly long latency and unpredictable, slow progression of prostate cancer, herbal medicine may be a suitable alternative for protection against the disease with potential for development for long-term use without significant side-effects. Research on potential drug molecules from herbal medicines is slowly emerging for prostate cancer treatment; however, investigations are still hampered by various technical concerns such as a lack of validated drug targets, lack of animal models relevant to the human disease, as well as a lack of strategies and methodologies to effectively analyze the active ingredients contained in herbal medicines, their pharmacokinetics, pharmacodynamics and so on. Here, we summarize recent advances in anticancer herbal medicine research for in vivo prostate cancer treatment. The most promising candidates are currently at the preclinical study stage and include the ethanol extracts of ka-mi-kae-kyuk-tang, a cocktail of ten Chinese and Korean herbs; honokiol, a biphenolic compound isolated from Magnolia officinalis (Hòupò in Chinese); and Wedelia chinensis. Potential toxicities or severe side effects as a result of long-term use, which are the main concerns that still need to be investigated prior to the commencement of clinical studies of these herbs and herbal formulas are discussed in this chapter.

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  1. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

    Yi-Ren Chen, Pei-Wen Hsiao, Feng-Ming Lin, Guan-James Wu & Chin-Hsien Tsai

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  1. Yi-Ren Chen
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  2. Pei-Wen Hsiao
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Correspondence to Pei-Wen Hsiao .

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  1. Queen Elizabeth Hospital, Department of Clinical Oncology, Room 1305, 13/F, Block R, Gascoigne Road 30, Kowloon, Hong Kong, China, People's Republic

    William C.S. Cho

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Chen, YR., Hsiao, PW., Lin, FM., Wu, GJ., Tsai, CH. (2012). Evidence-based Anticancer Materia Medica for Prostate Cancer. In: Cho, W. (eds) Materia Medica for Various Cancers. Evidence-based Anticancer Complementary and Alternative Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1983-5_6

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