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Electrospinning and Tissue Engineering

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Advances on Modeling in Tissue Engineering

Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 20))

Abstract

We review how the process of generating scaffolds for tissue engineering using the process of electrospinning sits alongside other more established pro cedures for the preparation of scaffolds. We identify the key potential advantages of electrospinning for constructing scaffolds and we explore some of the remaining challenges. Several of these focus on the solvent and the desirability of using water for biological systems rather than highly volatile solvents such as those based on fluoroalcohols which lead, for example to the denaturing of collagen. We show how the control of temperature opens several opportunities as does the inclusion of additives to influence conductivity and viscosity. We show how the use of alternative electrode arrangements can lead to a control of the internal organisation with potential for property enhancement. It is reasonable to currently see electrospinning as an area dominated by experimental work but there is a growing computational element and we review how far such developments have reached and the potential for identifying new solutions for the application of electrospinning to tissue engineering.

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Authors and Affiliations

  1. University of Reading, Whiteknights, Reading, RG6 6AF, UK

    Geoffrey R. Mitchell & Fred Davis

  2. Centre for Rapid and. Sustainable Product Development, Polytechnic Institute of Leiria, Campus 5. Rua das Olhalvas, 2414-016, Leiria, Portugal

    Geoffrey R. Mitchell

Authors
  1. Geoffrey R. Mitchell
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  2. Fred Davis
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Correspondence to Geoffrey R. Mitchell .

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Editors and Affiliations

  1. IDMEC – Instituto de Engenharia Mecânica, Instituto Superior Técnico, Av. Rovisco Pais 1, Lisboa, 1049-001, Portugal

    Paulo R. Fernandes

  2. Polytechnic Institute of Leiria, Centre for Rapid and Sustainable Product, Leiria, Portugal

    Paulo Jorge Bártolo

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Mitchell, G.R., Davis, F. (2011). Electrospinning and Tissue Engineering. In: Fernandes, P., Bártolo, P. (eds) Advances on Modeling in Tissue Engineering. Computational Methods in Applied Sciences, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1254-6_7

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  • DOI: https://doi.org/10.1007/978-94-007-1254-6_7

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-1253-9

  • Online ISBN: 978-94-007-1254-6

  • eBook Packages: EngineeringEngineering (R0)

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