Very High Protein Production Levels with a New Transient and Serum-Free Expression System Based on Human CAP Cells

Abstract

Human CAP (CEVEC’s Amniocyte Production) cells allow for stable production of recombinant proteins with excellent biologic activity and therapeutic efficacy as a result of authentic posttranslational modification. Based on human CAP cells a new transient expression system has been developed, that is scalable and serum-free and enables extremely high production yields of recombinant proteins within a few days. The novel CAP-T transient human cell expression system is a rapid and versatile tool for fast and serum-free protein expression for screening, assay development, drug discovery and early stage pre-clinical drug development. From gene to mg amounts within two weeks – fast process times and high yields even for highly glycosylated proteins are key feature of the CAP-T expression system.