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Probiotic-Pathogen Interactions and Enteric Cytoprotection

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Probiotic Bacteria and Enteric Infections

Abstract

The intestinal epithelium forms a physicochemical barrier that impedes enteric pathogens from invading the epithelium and cause disease. In order for a particular pathogen to colonise the intestinal mucosa, it needs to break and cross this barrier. The barrier consists of a low pH area mainly resulting from carbohydrate fermentation, a mucus layer along the epithelial surface, an epithelial mechanical barrier maintained by intercellular tight junctions, an apical actin cytoskeleton, and the presence of stable microbiota. In addition, this barrier produces inflammatory mediators, mainly cytokines.

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Authors and Affiliations

  1. Department of Veterinary Pathology, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3203, Chuo Kikuu, Morogoro, Tanzania

    Joshua J. Malago

  2. Faculty of Veterinary Medicine, Dept of Pathobiology, Division Pathology, Utrecht University, Yalelaan 1, 3508 TD, Utrecht, Netherlands

    Jos F.J.G. Koninkx

Authors
  1. Joshua J. Malago
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  2. Jos F.J.G. Koninkx
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Correspondence to Joshua J. Malago .

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Editors and Affiliations

  1. Faculty of Veterinary Medicine, Department of Veterinary Pathology, Sokoine University of Agriculture, Chuo Kikuu, Morogoro, Tanzania

    J.J. Malago

  2. Division Pathology, Dept of Pathobiology, Utrecht University, Yalelaan 1, Utrecht, 3508 TD, Netherlands

    J.F.J.G. Koninkx

  3. Biotechnical Faculty, Zootechnical Department, University of Ljubljana, Domžale, 1230, Slovenia

    R. Marinsek-Logar

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Malago, J.J., Koninkx, J.F. (2011). Probiotic-Pathogen Interactions and Enteric Cytoprotection. In: Malago, J., Koninkx, J., Marinsek-Logar, R. (eds) Probiotic Bacteria and Enteric Infections. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0386-5_13

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